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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
CyclinA
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "CyclinA" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-N4087
CAS No.: 66663-90-9
NU6102 is a potent CDK1 and CDK2 inhibitor with IC50s of 9.5 nM and 5.4 nM for CDK1/cyclinB and CDK2/cyclinA3, respectively. NU6102 shows selectivity for CDK1/CDK2 over CDK4 (IC50 of 1.6 μM), DYRK1A (IC50 of 0.9 μM), PDK1 (IC50 of 0.8 μM) and ROCKII (IC50 of 0.6 μM) .
Research Areas:
PKCζ-IN-1 is a PKCζ-selective inhibitor with an IC50 of 5.18 nM against human PKCζ. PKCζ-IN-1 also inhibits CDK2 with an IC50 of 1.04 μM. PKCζ-IN-1 is applicable to research related to immune and inflammatory diseases .
Cat. No.: HY-P10680
Cat. No.: HY-151375
CAS No.: 2423045-06-9
CDK9/10/GSK3β-IN-1 (compound 13c) is a kinase inhibitor (Flavopiridol (HY-10005) analogue) that effectively inhibits HsGSK3β (IC50=59 nM), HsCDK9/CyclinT (IC50=64 nM), HsCDK5/p25 (IC50=1.093 μM) and HsCDK2/CyclinA (IC50=1.725 μM). CDK9/10/GSK3β-IN-1 has anti-cancer cellular activity comparable to or higher than that of Flavopiridol. CDK9/10/GSK3β-IN-1 shows high anti-proliferative activity in vitro against up to seven cancer cell lines .
Cat. No.: HY-155180
CAS No.: 2685870-87-3
FD2056 is a potent and orally active PI3K inhibitor. FD2056 inhibits PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ with IC50s of 0.30, 0.80, 1.10, 0.42 nM. FD2056 also inhibits CDK2-CyclinA2 and CDK4-CyclinD3 with IC50 of 115.95 and 2782.15 nM. FD2056 inhibits breast cancer cell proliferation with IC50s of 1.06, 0.04, 1.40 μM for MDA-MB-231, MDA-MB-468, MCF-7 cells. FD2056 also induces cancer apoptosis and inhibits tumor growth .
Cat. No.: HY-P83591A
Synonyms: CCN1; CCNA; CCNA1; CCNA2; CT146; Cyclin-A; Cyclin-A1; Cyclin-A2
Cat. No.: HY-123238
CAS No.: 750575-23-6
AG-024104 is a CDK inhibitor with Ki values of 2.3 nM (CDK1/cyclinB), 1.8 nM (CDK2/cyclinA), and 0.67 nM (CDK4/cyclinD). AG-024104 functionally inhibits kinase activity of CDK1/cyclinB, CDK2/cyclinA, and CDK4/cyclinD. AG-024104 serves as a negative control for peripheral leukocyte toxicity studies in preclinical development .
Cat. No.: HY-P703551
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCNA2; Cyclin-A2; Prev. CCN1; Cyclin A; Prev. CCNA; Cyclin A2; Cyclin-A
Species:
Human
Source:
E. coli
Cat. No.: HY-P702675
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CDK2; CDKN2; Cyclin Dependent Kinase 2; Cdc2-Related Protein Kinase; Cell Division Protein Kinase 2; Cyclin-Dependent Kinase; Cyclin-Dependent Kinase 2; P33(CDK2); P33 Protein Kinase; CCNA2; Cyclin-A2; Prev. CCN1; Cyclin A; Prev. CCNA; Cyclin A2; Cyclin-A
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
