DPA

By Targets:	5 alpha Reductase (1) Biochemical Assay Reagents (2) CCR (1) Checkpoint Kinase (Chk) (1) CXCR (1) Cytochrome P450 (1) Drug Derivative (3) Drug Intermediate (3) Drug Isomer (1) Drug Metabolite (1) Fluorescent Dye (4) FXR (1) GPR84 (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (3) MMP (3) NF-κB (1) PPAR (1) Small Interfering RNA (siRNA) (1) STAT (1) TNF Receptor (1) TSPO (3)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Inflammation/Immunology (8) Neurological Disease (2)
Click Chemistry:	Azide (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131498

*MOCAc-PLGL(Dpa)AR* Mca-Pro-Leu-Gly-Leu-DPA-Ala-Arg-NH2	Fluorescent Dye MMP	Cancer
MOCAc-PLGL (Dpa) AR (Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH₂) is a synthetic fluorescent substrate mainly used for in vitro enzymatic activity assays of MMP-7 (detection at 393 nm after excitation at 328 nm). MOCAc-PLGL (Dpa) AR is specifically cleaved and hydrolyzed by MMP-7 at the Gly-Leu peptide bond, allowing enzymatic activity to be monitored via fluorometry or HPLC (DMSO is usually added to ensure sufficient dissolution when determining kinetic parameters). MOCAc-PLGL (Dpa) AR is used to accurately evaluate the catalytic activity and pH dependence of recombinant mature human MMP-7 in vitro. MOCAc-PLGL (Dpa) AR is suitable for research on the mechanisms of tumor metastasis and invasion, particularly in fields such as prostate cancer, colon cancer, lung cancer and breast cancer .\n

HY-122607

DPA-714	Mitochondrial Metabolism TSPO	Inflammation/Immunology Cancer
DPA-714 is a high affinity translocator protein (TSPO) ligand (K_i=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. ^18FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model .

HY-P3722

*Mca-PLAQAV-Dpa-RSSSR-NH2* 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-N7864

Osbond acid all-cis-4,7,10,13,16-Docosapentaenoic acid	Biochemical Assay Reagents	Others
Docosapentaenoic acid (DPA) is a 22-carbon fatty acid found in fish oil. It is a minor component of total serum unsaturated fatty acids in humans, ranging from 0.1% to 1%, and increasing with dietary supplementation. all-cis-4,7,10,13,16-DPA, also known as Austrian acid, is an isomer of DPA. It is an omega-6 fatty acid formed by the extension and desaturation of arachidonic acid. During fatty acid desaturase syndrome, levels of this fatty acid may be reduced, which may affect development. Upregulated hepatic elongate expression of very long fatty acid protein 6 and elevated levels of very long chain fatty acids, including all-cis 4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a precancerous disease of hepatocellular carcinoma.

HY-P3722A

*Mca-PLAQAV-Dpa-RSSSR-NH2 TFA* 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-400882

*Tosylate-DPA-714*	Drug Derivative Drug Intermediate TSPO	Neurological Disease Inflammation/Immunology
Tosylate-DPA-714 is a GMP-grade precursor for the radiosynthesis of DPA-714 (HY-122607). It crosses the blood-brain barrier and exhibits steroidogenic activity. DPA-714 is a specific ligand for the 18 kDa translocator protein (TSPO) with a K_i of 7.0 nM. Tosylate-DPA-714 is safe and does not bind to central benzodiazepine receptors (benzodiazepine receptor). As a radiolabeling precursor, Tosylate-DPA-714 reacts with ¹⁸F via nucleophilic aliphatic substitution to form ¹⁸F-DPA-714, enabling specific targeted binding to TSPO. ¹⁸F-DPA-714 accurately reflects the level of neuroinflammation mediated by microglial activation, and is used for PET molecular imaging of neurological diseases such as Alzheimer's disease and multiple sclerosis .

HY-165071

(±)16(17)-EpDPA (±)16,17 EDP; (±)16,17-Epoxy docosapentaenoic acid; (±)16,17-Epoxy DPA	Drug Isomer	Others
(±)16(17)-EpDPA is the DHA homolog of (±)14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA.

HY-W088320

4-Hydroxydiphenylamine p-Anilinophenol; 4-Hydroxy-DPA	Drug Intermediate	Others
4-Hydroxydiphenylamine (p-Anilinophenol; 4-Hydroxy-DPA) is an aromatic amine organic compound. 4-Hydroxydiphenylamine has antioxidant activity and is also used as a catalyst or intermediate in some chemical reactions to synthesize other compounds. 4-Hydroxydiphenylamine can be used in the research of environmental science and toxicology .

HY-B1734

16-Dehydropregnenolone acetate 16-DPA	FXR 5 alpha Reductase Cytochrome P450 Drug Intermediate	Cardiovascular Disease Cancer
16-Dehydropregnenolone acetate (16-DPA), a sterols compound, is an orally active 17α-hydroxylase and 5α-reductase inhibitor. 16-Dehydropregnenolone is also a potent bile acid receptor (BAR)/farnesoid X receptor (FXR) antagonist. 16-Dehydropregnenolone hypolipidemic and anticancer effects. 16-Dehydropregnenolone acetate (16-DPA) is the drug intermediate that can be used for synthesis of Dexamethasone (HY-14648) and related other steroidal pharmacophores .

HY-W746625

all-cis-4,7,10,13,16-Docosapentaenoic acid methyl ester all-cis-4,7,10,13,16-DPA methyl ester	Drug Derivative	Cardiovascular Disease Neurological Disease Inflammation/Immunology
all-cis-4,7,10,13,16-Docosapentaenoic acid methyl ester (all-cis-4,7,10,13,16-DPA methyl ester) is the methyl ester derivative of all-cis-4,7,10,13,16-Docosapentaenoic acid, that can be used as a nutritional supplement to increase all-cis-4,7,10,13,16-Docosapentaenoic acid intake. all-cis-4,7,10,13,16-Docosapentaenoic acid is a long-chain polyunsaturated fatty acid, that plays a role in cardiovascular health, neuroprotection, and inflammation regulation .

HY-122607R

DPA-714 (Standard)	Mitochondrial Metabolism	Inflammation/Immunology Cancer
DPA-714 (Standard) is the analytical standard of DPA-714. This product is intended for research and analytical applications. DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. 18FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model .

HY-W189421

Diphenic anhydride DPA	Biochemical Assay Reagents	Others
Diphenic anhydride (DPA) is a versatile reagent that can be used as a catalyst in many organic synthetic processes, such as polymer synthesis .

HY-151559

*Zn-DPA-maytansinoid conjugate 1*	Checkpoint Kinase (Chk) STAT CXCR CCR	Cancer
Zn-DPA-maytansinoid conjugate 1 is a small molecule-based maytansinoid conjugate targeting immune checkpoint. Zn-DPA-maytansinoid conjugate 1 induces lasting regression of tumor growth and rejuvenates tumor microenvironment (TME) to an "inflamed hot tumor" .

HY-168782

Resolvin D2 n-3 DPA	TNF Receptor Interleukin Related	Inflammation/Immunology
Resolvin D2 n-3 DPA is a specialized proresolving mediator (SPM). Resolvin D2 n-3 DPA (1 nM) can reduce the chemotaxis and adhesion of human neutrophils induced by TNF-α. Resolvin D2 n-3 DPA (100 ng/mouse; intravenous injection) can reduce neutrophil infiltration in the peritoneum and the levels of IL-6 and the chemokine (C-C motif) ligand 2 (CCL2) in a mouse model of inflammation induced by zinc oxide .

HY-RS06203

*HLA-DPA1 Human Pre-designed siRNA Set A*	Small Interfering RNA (siRNA)	Others
HLA-DPA1 Human Pre-designed siRNA Set A contains three designed siRNAs for HLA-DPA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HLA-DPA1 Human Pre-designed siRNA Set A HLA-DPA1 Human Pre-designed siRNA Set A

HY-W923496

all-cis-4,7,10,13,16-Docosapentaenoic acid ethyl ester SFE 24:5; all-cis-4,7,10,13,16-DPA Ethyl ester	Drug Derivative	Others
all-cis-4,7,10,13,16-Docosapentaenoic acid ethyl ester (SFE 24:5) is a derivative of Docosapentaenoic acid (DPA). DPA is a fatty acid found in fish oils .

HY-116115

17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid 17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA	NF-κB PPAR	Inflammation/Immunology
17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid (17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA) is an electrophilic oxo-derivative (EFOX) of the docosahexaenoic acid (DHA) (HY-B2167). 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is generated during inflammation by COX-2-catalyzed mechanism in activated macrophages. 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid acts as an agonist for PPARγ and a modulator for NF-κB signaling pathway, inhibits the production of pro-inflammatory cytokines and nitric oxide, and exhibits anti-inflammatory efficacy .

HY-122607S

DPA-714-d10	Isotope-Labeled Compounds Mitochondrial Metabolism TSPO	Inflammation/Immunology Cancer
DPA-714-d₁₀ is the deuterium labeled DPA-714 (HY-122607). DPA-714 is a high affinity translocator protein (TSPO) ligand (K_i=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. ¹⁸FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model.

HY-167754

Resolvin D5 n-3 DPA	GPR84	Inflammation/Immunology
Resolvin D5 n-3 DPA is a Docosapentaenoic acid (DPA) derived specialized proresolving lipid mediator (SPM). Resolvin D5 n-3 DPA is a GPR101, GPR12, and GPR84 agonist with EC₅₀s of 4.6 pM, 14 pM, and 1.5 pM, respectively. Resolvin D5 n-3 DPA possesses potent pro-resolution and anti-inflammatory actions. Resolvin D5 n-3 DPA reduces cell adhesion onto TNF-α-activated human endothelial monolayers. Resolvin D5 n-3 DPA displays potent leukocyte-directed activities, upregulating the ability of neutrophils and macrophages to phagocytose bacteria. Resolvin D5 n-3 DPA can be used for the study of intestinal inflammation .

HY-172833

(±)19(20)-DiHDTE	Drug Metabolite	Others
(±)19(20)-DiHDTE is a an oxidized lipid compound. (±)19(20)-DiHDTE is the product formed when docosapentaenoic acid (DPA) is oxidatively metabolized by cytochrome P450.

HY-D3216

ER-Cu(II)	Fluorescent Dye	Others
ER-Cu (II) is an endoplasmic reticulum-selective fluorescent Cu ²⁺ probe. ER-Cu (II) localizes specifically to the endoplasmic reticulum of hepatocytes .

Cat. No.	Product Name	Type

HY-131498

*MOCAc-PLGL(Dpa)AR* Mca-Pro-Leu-Gly-Leu-DPA-Ala-Arg-NH2	Fluorescent Dyes
MOCAc-PLGL (Dpa) AR (Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH₂) is a synthetic fluorescent substrate mainly used for in vitro enzymatic activity assays of MMP-7 (detection at 393 nm after excitation at 328 nm). MOCAc-PLGL (Dpa) AR is specifically cleaved and hydrolyzed by MMP-7 at the Gly-Leu peptide bond, allowing enzymatic activity to be monitored via fluorometry or HPLC (DMSO is usually added to ensure sufficient dissolution when determining kinetic parameters). MOCAc-PLGL (Dpa) AR is used to accurately evaluate the catalytic activity and pH dependence of recombinant mature human MMP-7 in vitro. MOCAc-PLGL (Dpa) AR is suitable for research on the mechanisms of tumor metastasis and invasion, particularly in fields such as prostate cancer, colon cancer, lung cancer and breast cancer .\n

MOCAc-PLGL(Dpa)AR

Mca-Pro-Leu-Gly-Leu-DPA-Ala-Arg-NH2

Fluorescent Dyes

MOCAc-PLGL (Dpa) AR (Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH₂) is a synthetic fluorescent substrate mainly used for in vitro enzymatic activity assays of MMP-7 (detection at 393 nm after excitation at 328 nm). MOCAc-PLGL (Dpa) AR is specifically cleaved and hydrolyzed by MMP-7 at the Gly-Leu peptide bond, allowing enzymatic activity to be monitored via fluorometry or HPLC (DMSO is usually added to ensure sufficient dissolution when determining kinetic parameters). MOCAc-PLGL (Dpa) AR is used to accurately evaluate the catalytic activity and pH dependence of recombinant mature human MMP-7 in vitro. MOCAc-PLGL (Dpa) AR is suitable for research on the mechanisms of tumor metastasis and invasion, particularly in fields such as prostate cancer, colon cancer, lung cancer and breast cancer .\n

HY-D3216

ER-Cu(II)	Fluorescent Dyes
ER-Cu (II) is an endoplasmic reticulum-selective fluorescent Cu ²⁺ probe. ER-Cu (II) localizes specifically to the endoplasmic reticulum of hepatocytes .

Cat. No.	Product Name	Type

HY-N7864

Osbond acid all-cis-4,7,10,13,16-Docosapentaenoic acid	Biochemical Assay Reagents
Docosapentaenoic acid (DPA) is a 22-carbon fatty acid found in fish oil. It is a minor component of total serum unsaturated fatty acids in humans, ranging from 0.1% to 1%, and increasing with dietary supplementation. all-cis-4,7,10,13,16-DPA, also known as Austrian acid, is an isomer of DPA. It is an omega-6 fatty acid formed by the extension and desaturation of arachidonic acid. During fatty acid desaturase syndrome, levels of this fatty acid may be reduced, which may affect development. Upregulated hepatic elongate expression of very long fatty acid protein 6 and elevated levels of very long chain fatty acids, including all-cis 4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a precancerous disease of hepatocellular carcinoma.

Osbond acid

all-cis-4,7,10,13,16-Docosapentaenoic acid

Biochemical Assay Reagents

Docosapentaenoic acid (DPA) is a 22-carbon fatty acid found in fish oil. It is a minor component of total serum unsaturated fatty acids in humans, ranging from 0.1% to 1%, and increasing with dietary supplementation. all-cis-4,7,10,13,16-DPA, also known as Austrian acid, is an isomer of DPA. It is an omega-6 fatty acid formed by the extension and desaturation of arachidonic acid. During fatty acid desaturase syndrome, levels of this fatty acid may be reduced, which may affect development. Upregulated hepatic elongate expression of very long fatty acid protein 6 and elevated levels of very long chain fatty acids, including all-cis 4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a precancerous disease of hepatocellular carcinoma.

HY-W189421

Diphenic anhydride DPA	Biochemical Assay Reagents
Diphenic anhydride (DPA) is a versatile reagent that can be used as a catalyst in many organic synthetic processes, such as polymer synthesis .

Cat. No.	Product Name	Target	Research Area

HY-P3722

*Mca-PLAQAV-Dpa-RSSSR-NH2* 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-P3722A

*Mca-PLAQAV-Dpa-RSSSR-NH2 TFA* 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71697

	*HLA-DPA1 Protein, Human (His)* HLA-DPA1; HLA-DP1A; HLASBHLA class II histocompatibility antigen; DP alpha 1 chain; HLA-SB alpha chain; MHC class II DP3-alpha; MHC class II DPA1	Human	E. coli
	The HLA-DPA1 protein is critical in the immune system, binding antigens in the endocytic pathway of APCs and presenting them to the cell surface for recognition by CD4 T cells. The peptide binding cleft can accommodate peptides of 10-30 residues, mainly resulting from protein degradation. HLA-DPA1 Protein, Human (His) is the recombinant human-derived HLA-DPA1 protein, expressed by E. coli , with N-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-122607S

DPA-714-d10
DPA-714-d₁₀ is the deuterium labeled DPA-714 (HY-122607). DPA-714 is a high affinity translocator protein (TSPO) ligand (K_i=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. ¹⁸FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model.

DPA-714-d10

DPA-714-d₁₀ is the deuterium labeled DPA-714 (HY-122607). DPA-714 is a high affinity translocator protein (TSPO) ligand (K_i=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. ¹⁸FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model.

Host:	Mouse (4) Rabbit (2)
Reactivity:	Human (6) Rat (2)
Application:	IHC-P (6) WB (2) FC (4) ELISA (4)
Isotype:	IgG (2) IgG2a (2) IgG2b (2)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84161

	*HLA-DPA1 Antibody (YA3858)* DPA1; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DPA; HLA-DP1A; HLA-DPB1	WB, IHC-P, FC, ELISA	Human
	HLA-DPA1 Antibody (YA3858) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HLA-DPA1.

HY-P84162

	*HLA-DPA1 Antibody (YA3859)* DPA1; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DPA; HLA-DP1A; HLA-DPB1	IHC-P, FC, ELISA	Human, Rat
	HLA-DPA1 Antibody (YA3859) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to HLA-DPA1.

HY-P84161A

	*HLA-DPA1 Antibody (YA3858)(PBS only)* DPA1; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DPA; HLA-DP1A; HLA-DPB1	WB, IHC-P, FC, ELISA	Human
	HLA-DPA1 Antibody (YA3858) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HLA-DPA1.

HY-P84162A

	*HLA-DPA1 Antibody (YA3859)(PBS only)* DPA1; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DPA; HLA-DP1A; HLA-DPB1	IHC-P, FC, ELISA	Human, Rat
	HLA-DPA1 Antibody (YA3859) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to HLA-DPA1.

HY-P81436

	*HLA-DPA1 Antibody (YA1181)* HLA DPA1; major histocompatibility complex; class II; DP alpha 1; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DP1A	IHC-P	Human
	HLA-DPA1 Antibody (YA1181) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HLA-DPA1.

HY-P81436A

	*HLA-DPA1 Antibody (YA1181)(PBS only)* HLA DPA1; major histocompatibility complex; class II; DP alpha 1; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DP1A	IHC-P	Human
	HLA-DPA1 Antibody (YA1181) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HLA-DPA1.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-D3216

ER-Cu(II)		Azide
ER-Cu (II) is an endoplasmic reticulum-selective fluorescent Cu ²⁺ probe. ER-Cu (II) localizes specifically to the endoplasmic reticulum of hepatocytes .

Cat. No.	Product Name		Classification

HY-RS06203

*HLA-DPA1 Human Pre-designed siRNA Set A*		siRNAs Human Pre-designed siRNA Sets
HLA-DPA1 Human Pre-designed siRNA Set A contains three designed siRNAs for HLA-DPA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

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