Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
DPA
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "DPA" in MCE Product Catalog:
1
1 Cited Publications
Target:
Research Areas:
DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. 18FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model .
1
1 Cited Publications
Cat. No.: HY-P3722
CAS No.: 192723-42-5
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-P3722A
Target:
Research Areas:
Synonyms: Mca-Pro-Leu-Gly-Leu-DPA-Ala-Arg-NH2
Target:
Research Areas:
Cat. No.: HY-N7864
CAS No.: 25182-74-5
Synonyms: all-cis-4,7,10,13,16-Docosapentaenoic acid
Cat. No.: HY-400882
CAS No.: 958233-17-5
Target:
Research Areas:
Tosylate-DPA-714 is a GMP-grade precursor for the radiosynthesis of DPA-714 (HY-122607). It crosses the blood-brain barrier and exhibits steroidogenic activity. DPA-714 is a specific ligand for the 18 kDa translocator protein (TSPO) with a Ki of 7.0 nM. Tosylate-DPA-714 is safe and does not bind to central benzodiazepine receptors (benzodiazepine receptor). As a radiolabeling precursor, Tosylate-DPA-714 reacts with 18F via nucleophilic aliphatic substitution to form 18F-DPA-714, enabling specific targeted binding to TSPO. 18F-DPA-714 accurately reflects the level of neuroinflammation mediated by microglial activation, and is used for PET molecular imaging of neurological diseases such as Alzheimer's disease and multiple sclerosis .
Cat. No.: HY-165071
CAS No.: 155073-46-4
Synonyms: (±)16,17 EDP; (±)16,17-Epoxy docosapentaenoic acid; (±)16,17-Epoxy DPA
Target:
Research Areas:
(±)16(17)-EpDPA is the DHA homolog of (±)14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA.
Cat. No.: HY-W088320
CAS No.: 122-37-2
Synonyms: p-Anilinophenol; 4-Hydroxy-DPA; 4-HDPA
Target:
Research Areas:
4-Hydroxydiphenylamine (p-Anilinophenol; 4-Hydroxy-DPA; 4-HDPA) is an aromatic amine organic compound. 4-Hydroxydiphenylamine exhibits antioxidant activity, and also acts as a catalyst or intermediate in certain chemical reactions to participate in the synthesis of other compounds. 4-Hydroxydiphenylamine can be used in research in the fields of environmental science and toxicology .
Research Areas:
16-Dehydropregnenolone acetate (16-DPA), a sterols compound, is an orally active 17α-hydroxylase and 5α-reductase inhibitor. 16-Dehydropregnenolone is also a potent bile acid receptor (BAR)/farnesoid X receptor (FXR) antagonist. 16-Dehydropregnenolone hypolipidemic and anticancer effects. 16-Dehydropregnenolone acetate (16-DPA) is the drug intermediate that can be used for synthesis of Dexamethasone (HY-14648) and related other steroidal pharmacophores .
Cat. No.: HY-W746625
CAS No.: 31930-67-3
Synonyms: all-cis-4,7,10,13,16-DPA methyl ester
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
all-cis-4,7,10,13,16-Docosapentaenoic acid methyl ester (all-cis-4,7,10,13,16-DPA methyl ester) is the methyl ester derivative of all-cis-4,7,10,13,16-Docosapentaenoic acid, that can be used as a nutritional supplement to increase all-cis-4,7,10,13,16-Docosapentaenoic acid intake. all-cis-4,7,10,13,16-Docosapentaenoic acid is a long-chain polyunsaturated fatty acid, that plays a role in cardiovascular health, neuroprotection, and inflammation regulation .
Cat. No.: HY-122607R
CAS No.: 958233-07-3
Target:
Research Areas:
DPA-714 (Standard) is the analytical standard of DPA-714. This product is intended for research and analytical applications. DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. 18FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model .
Cat. No.: HY-W189421
CAS No.: 6050-13-1
Synonyms: DPA
Cat. No.: HY-151559
CAS No.: 3034629-04-1
Target:
Research Areas:
Zn-DPA-maytansinoid conjugate 1 is a small molecule-based maytansinoid conjugate targeting immune checkpoint. Zn-DPA-maytansinoid conjugate 1 induces lasting regression of tumor growth and rejuvenates tumor microenvironment (TME) to an "inflamed hot tumor" .
Cat. No.: HY-168782
CAS No.: 2093111-29-4
Target:
Research Areas:
Resolvin D2 n-3 DPA is a specialized proresolving mediator (SPM). Resolvin D2 n-3 DPA (1 nM) can reduce the chemotaxis and adhesion of human neutrophils induced by TNF-α. Resolvin D2 n-3 DPA (100 ng/mouse; intravenous injection) can reduce neutrophil infiltration in the peritoneum and the levels of IL-6 and the chemokine (C-C motif) ligand 2 (CCL2) in a mouse model of inflammation induced by zinc oxide .
Cat. No.: HY-RS06203
Target:
Research Areas:
HLA-DPA1 Human Pre-designed siRNA Set A contains three designed siRNAs for HLA-DPA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W923496
CAS No.: 142828-42-0
Synonyms: SFE 24:5; all-cis-4,7,10,13,16-DPA Ethyl ester
Target:
Research Areas:
all-cis-4,7,10,13,16-Docosapentaenoic acid ethyl ester (SFE 24:5) is a derivative of Docosapentaenoic acid (DPA). DPA is a fatty acid found in fish oils .
Cat. No.: HY-116115
CAS No.: 1233715-33-7
Synonyms: 17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA
Research Areas:
17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid (17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA) is an electrophilic oxo-derivative (EFOX) of the docosahexaenoic acid (DHA) (HY-B2167). 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is generated during inflammation by COX-2-catalyzed mechanism in activated macrophages. 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid acts as an agonist for PPARγ and a modulator for NF-κB signaling pathway, inhibits the production of pro-inflammatory cytokines and nitric oxide, and exhibits anti-inflammatory efficacy .
Cat. No.: HY-W667746
CAS No.: 386297-97-8
Research Areas:
DPA-713 is a blood-brain barrier-permeable, specific translocator protein (TSPO) ligand. DPA-713 binds exclusively to TSPO without interacting with central benzodiazepine receptors; its binding can be competitively displaced by excess unlabeled TSPO ligands. After 11C labeling, DPA-713 enables sensitive quantitative analysis of TSPO expression associated with microglial activation, allowing differentiation between normal and pathological brain tissues. DPA-713 can be used in studies related to neuroinflammation, neurodegenerative diseases, and recently onset schizophrenia .
Cat. No.: HY-122607S
Cat. No.: HY-167754
CAS No.: 1609382-32-2
Target:
Research Areas:
Resolvin D5 n-3 DPA is a Docosapentaenoic acid (DPA) derived specialized proresolving lipid mediator (SPM). Resolvin D5 n-3 DPA is a GPR101, GPR12, and GPR84 agonist with EC50s of 4.6 pM, 14 pM, and 1.5 pM, respectively. Resolvin D5 n-3 DPA possesses potent pro-resolution and anti-inflammatory actions. Resolvin D5 n-3 DPA reduces cell adhesion onto TNF-α-activated human endothelial monolayers. Resolvin D5 n-3 DPA displays potent leukocyte-directed activities, upregulating the ability of neutrophils and macrophages to phagocytose bacteria. Resolvin D5 n-3 DPA can be used for the study of intestinal inflammation .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
