1609382-32-2
Chemical Structure
Resolvin D5 n-3 DPA
- CAS No.: 1609382-32-2
- Formula:C22H34O4
- Molecular Weight:362.51
IUPAC Name: (7S,8E,10Z,13Z,15E,17S,19Z)-7,17-dihydroxydocosa-8,10,13,15,19-pentaenoic acid
InChIKey: JUBMLVBCKBUAQW-STWMVWSJSA-N
SMILES: [C@@H](/C=C/C=C\C/C=C\C=C\[C@H](C/C=C\CC)O)(CCCCCC(O)=O)O
Biological Activity: Resolvin D5 n-3 DPA is a Docosapentaenoic acid (DPA) derived specialized proresolving lipid mediator (SPM). Resolvin D5 n-3 DPA is a GPR101, GPR12, and GPR84 agonist with EC50s of 4.6 pM, 14 pM, and 1.5 pM, respectively. Resolvin D5 n-3 DPA possesses potent pro-resolution and anti-inflammatory actions. Resolvin D5 n-3 DPA reduces cell adhesion onto TNF-α-activated human endothelial monolayers. Resolvin D5 n-3 DPA displays potent leukocyte-directed activities, upregulating the ability of neutrophils and macrophages to phagocytose bacteria. Resolvin D5 n-3 DPA can be used for the study of intestinal inflammation[1][2][3].
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Resolvin D5 n-3 DPA | Resolvin D5 n-3 DPA is a Docosapentaenoic acid (DPA) derived specialized proresolving lipid mediator (SPM). Resolvin D5 n-3 DPA is a GPR101, GPR12, and GPR84 agonist with EC50s of 4.6 pM, 14 pM, and 1.5 pM, respectively. Resolvin D5 n-3 DPA possesses potent pro-resolution and anti-inflammatory actions. Resolvin D5 n-3 DPA reduces cell adhesion onto TNF-α-activated human endothelial monolayers. Resolvin D5 n-3 DPA displays potent leukocyte-directed activities, upregulating the ability of neutrophils and macrophages to phagocytose bacteria. Resolvin D5 n-3 DPA can be used for the study of intestinal inflammation. | |||||||||||||||||||||
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- [1]. Correction for Gobbetti et al., Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2322427121. [Content Brief]
- [2]. Ervik K, et al. Stereoselective Synthesis, Pro-resolution, and Anti-inflammatory Actions of RvD5n-3 DPA. J Nat Prod. 2023 Nov 24;86(11):2546-2553. [Content Brief]
- [3]. Flak MB, et al. GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections. J Clin Invest. 2020 Jan 2;130(1):359-373. [Content Brief]
Keywords
