1233715-33-7
Chemical Structure
17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid
Synonym(s): 17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA
- CAS No.: 1233715-33-7
- Formula:C22H32O3
- Molecular Weight:344.49
IUPAC Name: (7Z,10Z,13Z,15E,19Z)-17-oxodocosa-7,10,13,15,19-pentaenoic acid
InChIKey: PWVSFTLICCBISU-UCMLWGQMSA-N
SMILES: CC/C=C\CC(/C=C/C=C\C/C=C\C/C=C\CCCCCC(O)=O)=O
Biological Activity: 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid (17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA) is an electrophilic oxo-derivative (EFOX) of the docosahexaenoic acid (DHA) (HY-B2167). 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is generated during inflammation by COX-2-catalyzed mechanism in activated macrophages. 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid acts as an agonist for PPARγ and a modulator for NF-κB signaling pathway, inhibits the production of pro-inflammatory cytokines and nitric oxide, and exhibits anti-inflammatory efficacy[1].
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17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid | 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid (17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA) is an electrophilic oxo-derivative (EFOX) of the docosahexaenoic acid (DHA) (HY-B2167). 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is generated during inflammation by COX-2-catalyzed mechanism in activated macrophages. 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid acts as an agonist for PPARγ and a modulator for NF-κB signaling pathway, inhibits the production of pro-inflammatory cytokines and nitric oxide, and exhibits anti-inflammatory efficacy. | |||||||||||||||||||||
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