958233-17-5
Chemical Structure
Tosylate-DPA-714
- CAS. Nr.: 958233-17-5
- Formula:C29H34N4O5S
- Molecular Weight:550.67
InChIKey: QINFOCVXSSWPLV-UHFFFAOYSA-N
SMILES: O=C(CC1=C(N=C(C)C=C2C)N2N=C1C3=CC=C(OCCOS(=O)(C4=CC=C(C)C=C4)=O)C=C3)N(CC)CC
Biological Activity: Tosylate-DPA-714 is a GMP-grade precursor for the radiosynthesis of DPA-714 (HY-122607). It crosses the blood-brain barrier and exhibits steroidogenic activity. DPA-714 is a specific ligand for the 18 kDa translocator protein (TSPO) with a Ki of 7.0 nM. Tosylate-DPA-714 is safe and does not bind to central benzodiazepine receptors (benzodiazepine receptor). As a radiolabeling precursor, Tosylate-DPA-714 reacts with 18F via nucleophilic aliphatic substitution to form 18F-DPA-714, enabling specific targeted binding to TSPO. 18F-DPA-714 accurately reflects the level of neuroinflammation mediated by microglial activation, and is used for PET molecular imaging of neurological diseases such as Alzheimer's disease and multiple sclerosis[2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Tosylate-DPA-714 | 98.78% | Tosylate-DPA-714 is a GMP-grade precursor for the radiosynthesis of DPA-714 (HY-122607). It crosses the blood-brain barrier and exhibits steroidogenic activity. DPA-714 is a specific ligand for the 18 kDa translocator protein (TSPO) with a Ki of 7.0 nM. Tosylate-DPA-714 is safe and does not bind to central benzodiazepine receptors (benzodiazepine receptor). As a radiolabeling precursor, Tosylate-DPA-714 reacts with 18F via nucleophilic aliphatic substitution to form 18F-DPA-714, enabling specific targeted binding to TSPO. 18F-DPA-714 accurately reflects the level of neuroinflammation mediated by microglial activation, and is used for PET molecular imaging of neurological diseases such as Alzheimer's disease and multiple sclerosis. | ||||||||||||||||||||
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Similarity Score 0.74
HY-122607RDPA-714 (Standard) -
Similarity Score 0.71
HY-W667746DPA-713 -
Similarity Score 0.54
![2-(4-(6-Oxo-6,7,8,9-tetrahydro-2,7,9a-triazabenzo[cd]azulen-1-yl)phenoxy)ethyl 4-methylbenzenesulfonate Chemical Structure](//file.medchemexpress.com/product_pic/hy-402634.gif)
HY-4026342-(4-(6-Oxo-6,7,8,9-tetrahydro-2,7,9a-triazabenzo[cd]azulen-1-yl)phenoxy)ethyl 4-methylbenzenesulfonate -
Similarity Score 0.48
HY-12125BMS-561388 benzenesulfonate -
Similarity Score 0.47
HY-160489PTK7/β-catenin-IN-2 -
Similarity Score 0.46
HY-120947AV-105 -
Similarity Score 0.46
HY-119304GW-406381 -
Similarity Score 0.46
HY-105117Fantofarone -
Similarity Score 0.46
HY-168222Thalidomide-PEG1-OTs -
Explore the MedChemAI to find more analogs
![2-(4-(6-Oxo-6,7,8,9-tetrahydro-2,7,9a-triazabenzo[cd]azulen-1-yl)phenoxy)ethyl 4-methylbenzenesulfonate Chemical Structure](http://file.medchemexpress.com/product_pic/hy-402634.gif)
