958233-17-5
Chemical Structure
Tosylate-DPA-714
- CAS No.: 958233-17-5
- Formula:C29H34N4O5S
- Molecular Weight:550.67
InChIKey: QINFOCVXSSWPLV-UHFFFAOYSA-N
SMILES: O=C(CC1=C(N=C(C)C=C2C)N2N=C1C3=CC=C(OCCOS(=O)(C4=CC=C(C)C=C4)=O)C=C3)N(CC)CC
Biological Activity: Tosylate-DPA-714 is a GMP-grade precursor for the radiosynthesis of DPA-714 (HY-122607). It crosses the blood-brain barrier and exhibits steroidogenic activity. DPA-714 is a specific ligand for the 18 kDa translocator protein (TSPO) with a Ki of 7.0 nM. Tosylate-DPA-714 is safe and does not bind to central benzodiazepine receptors (benzodiazepine receptor). As a radiolabeling precursor, Tosylate-DPA-714 reacts with 18F via nucleophilic aliphatic substitution to form 18F-DPA-714, enabling specific targeted binding to TSPO. 18F-DPA-714 accurately reflects the level of neuroinflammation mediated by microglial activation, and is used for PET molecular imaging of neurological diseases such as Alzheimer's disease and multiple sclerosis[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tosylate-DPA-714 | 98.78% | Tosylate-DPA-714 is a GMP-grade precursor for the radiosynthesis of DPA-714 (HY-122607). It crosses the blood-brain barrier and exhibits steroidogenic activity. DPA-714 is a specific ligand for the 18 kDa translocator protein (TSPO) with a Ki of 7.0 nM. Tosylate-DPA-714 is safe and does not bind to central benzodiazepine receptors (benzodiazepine receptor). As a radiolabeling precursor, Tosylate-DPA-714 reacts with 18F via nucleophilic aliphatic substitution to form 18F-DPA-714, enabling specific targeted binding to TSPO. 18F-DPA-714 accurately reflects the level of neuroinflammation mediated by microglial activation, and is used for PET molecular imaging of neurological diseases such as Alzheimer's disease and multiple sclerosis. | ||||||||||||||||||||
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Keywords
