140430-53-1
Chemical Structure
Mca-PLGL-Dpa-AR-NH2
Synonym(s): Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
- CAS No.: 140430-53-1
- Formula:C49H68N14O15
- Molecular Weight:1093.15
IUPAC Name: (S)-N-((6S,9S,12S,15S,21S)-1-amino-6-carbamoyl-12-(((2,4-dinitrophenyl)amino)methyl)-1-imino-15-isobutyl-9,23-dimethyl-8,11,14,17,20-pentaoxo-2,7,10,13,16,19-hexaazatetracosan-21-yl)-1-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetyl)pyrrolidine-2-carboxamide
InChIKey: RQASLOJQHHELIQ-QJSKOQLASA-N
SMILES: N=C(N)NCCC[C@@H](C(N)=O)NC([C@H](C)NC([C@H](CNC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O)NC([C@H](CC(C)C)NC(CNC([C@H](CC(C)C)NC([C@H]2N(C(CC(C3=CC=C(OC)C=C3O4)=CC4=O)=O)CCC2)=O)=O)=O)=O)=O)=O
Biological Activity:
MOCAc-PLGL (Dpa) AR (Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) is a synthetic fluorescent substrate mainly used for in vitro enzymatic activity assays of MMP-7 (detection at 393 nm after excitation at 328 nm). MOCAc-PLGL (Dpa) AR is specifically cleaved and hydrolyzed by MMP-7 at the Gly-Leu peptide bond, allowing enzymatic activity to be monitored via fluorometry or HPLC (DMSO is usually added to ensure sufficient dissolution when determining kinetic parameters). MOCAc-PLGL (Dpa) AR is used to accurately evaluate the catalytic activity and pH dependence of recombinant mature human MMP-7 in vitro. MOCAc-PLGL (Dpa) AR is suitable for research on the mechanisms of tumor metastasis and invasion, particularly in fields such as prostate cancer, colon cancer, lung cancer and breast cancer[1][2][3].\n
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mca-PLGL-Dpa-AR-NH2 | 99.65% | MOCAc-PLGL (Dpa) AR (Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) is a synthetic fluorescent substrate mainly used for in vitro enzymatic activity assays of MMP-7 (detection at 393 nm after excitation at 328 nm). MOCAc-PLGL (Dpa) AR is specifically cleaved and hydrolyzed by MMP-7 at the Gly-Leu peptide bond, allowing enzymatic activity to be monitored via fluorometry or HPLC (DMSO is usually added to ensure sufficient dissolution when determining kinetic parameters). MOCAc-PLGL (Dpa) AR is used to accurately evaluate the catalytic activity and pH dependence of recombinant mature human MMP-7 in vitro. MOCAc-PLGL (Dpa) AR is suitable for research on the mechanisms of tumor metastasis and invasion, particularly in fields such as prostate cancer, colon cancer, lung cancer and breast cancer.\n |
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- [1]. Oneda H, et al. Inhibitory effects of green tea catechins on the activity of human matrix metalloproteinase 7 (matrilysin). J Biochem. 2003;133(5):571-576. [Content Brief]
- [2]. Muta Y, et al. Expression in Escherichia coli, refolding, and purification of the recombinant mature form of human matrix metalloproteinase 7 (MMP-7). Biosci Biotechnol Biochem. 2010;74(12):2515-2517. [Content Brief]
- [3]. Muta Y, et al. Inhibitory effects of lignans on the activity of human matrix metalloproteinase 7 (matrilysin). J Agric Food Chem. 2004;52(19):5888-5894. [Content Brief]
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