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Results for "

DesE_D

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dihydroceramide Desaturase 1 (DES1) (2) 5-HT Receptor (1) Adrenergic Receptor (1) Androgen Receptor (1) Angiotensin Receptor (1) Antibiotic (1) Bacterial (3) Biochemical Assay Reagents (2) Bombesin Receptor (1) Bradykinin Receptor (10) Drug Derivative (1) Drug Metabolite (2) Fluorescent Dye (1) GCGR (5) GHSR (2) GnRH Receptor (10) HIV (1) HIV Protease (1) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (5) Natriuretic Peptide Receptor (NPR) (1) Neprilysin (1) Neuropeptide B/W Receptor (1) NF-κB (1) Opioid Receptor (1) Orphan Receptor (1) Oxytocin Receptor (1) PROTAC Linkers (2) Ser/Thr Protease (1) Small Interfering RNA (siRNA) (3) Somatostatin Receptor (1) TNF Receptor (1) Vasopressin Receptor (2)
By Research Areas:	Cancer (8) Cardiovascular Disease (7) Endocrinology (9) Infection (2) Inflammation/Immunology (13) Metabolic Disease (14) Neurological Disease (5)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Dihydroceramide Desaturase 1 (DES1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0298A

*[Des-Arg9]-Bradykinin acetate* 1 Publications Verification	Bradykinin Receptor	Inflammation/Immunology Endocrinology
[Des-Arg9]-Bradykinin acetate is a Bradykinin B₁ receptor agonist that displays selectivity for B₁ over B₂ receptors.

HY-121309

Doxorubicinone 2 Publications Verification Adriamycin aglycone; Adriamycinone	NF-κB TNF Receptor Interleukin Related Drug Derivative	Inflammation/Immunology Cancer
Doxorubicinone (Adriamycin aglycone) is the aglycone of the antibiotic Doxorubicin (HY-15142A), i.e., its sugar-free parent nucleus structure. Doxorubicinone does not induce DNA damage or bind to RelA, but still downregulates the expression of pro-inflammatory cytokines (such as TNF, IL-12, etc.) regulated by the NF-κB pathway. Doxorubicinone can be used in sepsis-related research .

HY-P1526

*ANP [Des18-22] 4-23 amide (rat)*	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
ANP [Des18-22] 4-23 amide rat is a polypeptide fragment of rat atrial natriuretic peptide (ANP) that specifically binds NPR-C .

HY-163472

PR280	Dihydroceramide Desaturase 1 (DES1)	Neurological Disease Metabolic Disease Cancer
PR280 is a dihydroceramide desaturase 1 (Des1) inhibitor with an IC₅₀ of 700 nM. PR280 is used for the research of metabolic diseases, cancers, and neurodegenerative diseases .

HY-P1366

des-Gln14-Ghrelin 1 Publications Verification	GHSR	Metabolic Disease
des-Gln14-Ghrelin is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca ²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM .

HY-P4463

*(Des-Pyr1)-LHRH*	GnRH Receptor	Others
(Des-Pyr1)-LHRH is a Polypeptide Internal Standard, identical to (Des-Pyr1)-GnRH, which can be identified through peptide screening. Peptide screening is a research tool that mainly collects active polypeptides via immunoassays. It can be applied to protein interaction, functional analysis, epitope screening, especially in the field of active molecule research and development. (Des-Pyr1)-LHRH can serve as an internal standard (ISTD) for mass spectrometry analysis .

HY-P0048

*(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH* 1 Publications Verification Surfagon	GnRH Receptor	Others
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon, Mwt 1167.34 Da) is an agonist of gonadotropin-releasing hormone (GnRH). (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH can be used as an internal standard for the LC-MS analysis of leuprorelide acetate. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH has potential applications in biochemical analysis and fertility .

HY-122402

Umirolimus	Bacterial	Inflammation/Immunology
Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used agent-eluting stent (DES) applications .

HY-P4676

*Lys-(Des-Arg9,Leu8)-Bradykinin*	Bradykinin Receptor	Inflammation/Immunology
Lys-(Des-Arg9,Leu8)-Bradykinin is a selective bradykinin B1 receptor (BDKRB1) antagonist. Lys-(Des-Arg9,Leu8)-Bradykinin inhibits local inflammatory edema. Lys-(Des-Arg9,Leu8)-Bradykinin induces the production of systemic acute-phase proteins. Lys-(Des-Arg9,Leu8)-Bradykinin is applicable to research related to peptidoglycan-polysaccharide-induced acute arthritis .

HY-P1143A

*[Des-His1,Glu9]-Glucagon amide TFA*	GCGR	Metabolic Disease
[Des-His1,Glu9]-Glucagon amide TFA is a potent and peptide antagonist of the glucagon receptor, with a pA₂ of 7.2. [Des-His1,Glu9]-Glucagon amide TFA is potentially useful in the study of the pathogenesis of diabetes .

HY-103291

*Sar-[D-Phe8]-des-Arg9-Bradykinin*	Bradykinin Receptor	Inflammation/Immunology Endocrinology
Sar-[D-Phe8]-des-Arg9-Bradykinin is a agonist of B1 receptor. Sar-[D-Phe8]-des-Arg9-Bradykinin selectively amplifies the contractile response when incubation with human recombinant interleukin-1 β (IL-1 β) in rabbit aortic rings .

HY-P1143

*[Des-His1,Glu9]-Glucagon amide*	GCGR	Metabolic Disease
[Des-His1,Glu9]-Glucagon amide is a potent and peptide antagonist of the glucagon receptor, with a pA₂ of 7.2. [Des-His1,Glu9]-Glucagon amide is potentially useful in the study of the pathogenesis of diabetes .

HY-P4541

*(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14)*	Bombesin Receptor	Cancer
(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14) is a bombesin (BBN) antagonist and can be used for the research of cancer .

HY-N9542

Dimethyl Citric acid 1 Publications Verification	Others	Others
Dimethylurea/citric acid is a highly efficient deep eutectic solvent (DES). Dimethylurea/citric acid can be used as a catalyst and a green reaction medium for the synthesis of bis(indolyl)methanes, quinolines and aryl-4, 5-diphenyl-1H-imidazoles.

HY-P4397

*(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin*	Oxytocin Receptor	Endocrinology
(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin, an oxytocin receptor antagonist, abolishes oxytocin-enhanced inhibitory postsynaptic currents in CA1 pyramidal neurons .

HY-P2828

*[Des-Pro2]-Bradykinin*	Ser/Thr Protease Others	Others
[Des-Pro2]-Bradykinin is a protease inhibitor. [Des-Pro2]-Bradykinin prevents the degradation of methionine enkephalin .

HY-P4440

*(Des-Gly10,Des-Ser4,D-Leu6,Pro-NHEt9)-LHRH*	GnRH Receptor	Others
(Des-Gly10,Des-Ser4,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P3209

Des-Arg9-[Leu8]-Bradykinin acetate	Bradykinin Receptor	Inflammation/Immunology
Des-Arg9-[Leu8]-Bradykinin acetate is potent bradykinin receptor 1 (B1R) antagonist. Des-Arg9-[Leu8]-Bradykinin acetate can be used for renal fibrosis research .

HY-P11363

*(Des-Asp1,Ile8)-Angiotensin II*	Angiotensin Receptor	Cardiovascular Disease
(Des-Asp1,Ile8)-Angiotensin II is a peptide related to angiotensin II. (Des-Asp1,Ile8)-Angiotensin II can be used for studying the interaction between angiotensin II and its receptors .

HY-P5518A

*[Des-Arg10]-HOE I40 TFA*	Bradykinin Receptor	Inflammation/Immunology Endocrinology
[Des-Arg10]-HOE I40 TFA is a potent bradykinin B1 receptor antagonist .

HY-103295A

*Lys-[Des-Arg9]Bradykinin TFA*	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a K_i of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin TFA has low inhibitory activity on B2 receptors .

HY-P0298

*[Des-Arg9]-Bradykinin*	Bradykinin Receptor	Inflammation/Immunology Endocrinology
[Des-Arg9]-Bradykinin is a Bradykinin (B₁) receptor agonist that displays selectivity for B₁ over B₂ receptors.

HY-P4432

*(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon)*	GnRH Receptor	Endocrinology
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon) is a GnRH analog that induces ovulation and/or spawning in farmed fish .

HY-P4413

*(Des-Glu5)-ACTH (1-24) (human, bovine, rat)*	Androgen Receptor	Endocrinology
(Des-Glu5)-ACTH (1-24) (human, bovine, rat) is an analogue of Adrenocorticotropic hormone (ACTH; HY-106373). ACTH is a polypeptide tropic hormone produced by the anterior pituitary gland, regulating cortisol and androgen production .

HY-W040270

Amino-PEG10-amine	PROTAC Linkers	Cancer
Amino-PEG10-amine, a PEG-based PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer .

HY-D1346

610CP	Fluorescent Dye	Others
610CP is a new type of actin labeling dye. It dissolves in organic solvents. In DMSO the 610CP excitation/emission wavelength is between 609 and 634 nm. 610CP is a fluorescent dye that penetrates living cells. Upon cell entry, 610CP binds to Bromo-des-methyl-Jasplakinolide Therefore, 610CP dye can be used to stain actin fluorescence images with low background and high resolution.

HY-P4441

*(Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH*	GnRH Receptor	Others
(Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-15899

Des(benzylpyridyl) Atazanavir	HIV Protease HIV Drug Metabolite	Infection
Des(benzylpyridyl) Atazanavir (compound M1) is a N-dealkylation product of Atazanavir (HY-17367) metabolite. Atazanavir is a highly selective HIV-1 protease inhibitor. Des(benzylpyridyl) Atazanavir may contribute to the effectiveness Atazanavir but also to the toxicity and interactions. Des(benzylpyridyl) Atazanavir can be used for further research of Atazanavir effects .

HY-103295

*Lys-[Des-Arg9]Bradykinin*	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
Lys-[Des-Arg9]Bradykinin, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a K_i of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin has low inhibitory activity on B2 receptors .

HY-P4467

*(Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH* (Des-Pyr1)-Leuprolide	GnRH Receptor	Others
(Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-122402S

Umirolimus-d5	Isotope-Labeled Compounds Bacterial	Inflammation/Immunology
Umirolimus-d₅ is the deuterium labeled Umirolimus (HY-122402). Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used agent-eluting stent (DES) applications .

HY-130411

Amino-PEG11-amine	PROTAC Linkers	Cancer
Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer .

HY-132795S

Des(1-cyclohexanol) Venlafaxine-d6	Isotope-Labeled Compounds	Others
Des(1-cyclohexanol) Venlafaxine-d₆ is the deuterium labeled Des(1-cyclohexanol) Venlafaxine .

HY-P5713

Des(8-14)brevinin-1PMa	Bacterial	Infection
Des(8-14)brevinin-1PMa is a host-defense peptide that exhibits antimicrobial activity against Staphylococcus aureus and Echerichia coli. Des(8-14)brevinin-1PMa also shows hemolytic activity .

HY-RS03703

DES Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DES Human Pre-designed siRNA Set A contains three designed siRNAs for DES gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DES Human Pre-designed siRNA Set A DES Human Pre-designed siRNA Set A

HY-RS23545

Des Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Des Rat Pre-designed siRNA Set A contains three designed siRNAs for Des gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Des Rat Pre-designed siRNA Set A Des Rat Pre-designed siRNA Set A

HY-Z6430

Des-4-fluorobenzyl mosapride	5-HT Receptor	Neurological Disease
Des-4-fluorobenzyl mosapride is the primary metabolite of Mosapride (HY-B0189). Mosapride is an orally active gastroenterokinetic compound and is a 5HT4 agonist.

HY-RS17101

Des Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Des Mouse Pre-designed siRNA Set A contains three designed siRNAs for Des gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Des Mouse Pre-designed siRNA Set A Des Mouse Pre-designed siRNA Set A

HY-169836

Des-ethyl-carafiban	Integrin	Cardiovascular Disease
Des-ethyl-carafiban (Compound 44) is a fibrinogen receptor antagonist that can effectively inhibit platelet aggregation induced by multiple agonists. Des-ethyl-carafiban can be used in the research of thrombotic diseases .

HY-P3608

*[Des-His1,Glu9] Glucagon*	GCGR	Metabolic Disease
[Des-His1,Glu9] Glucagon is a potent glucagon receptor system peptide antagonist. [Des-His1,Glu9] Glucagon enhances the glucose-stimulated release of insulin from pancreatic islet cells. [Des-His1,Glu9] Glucagon can be used to research diabetes .

HY-P3542

Des His1, Glu8 Exendin-4	GCGR	Metabolic Disease
Des His1, Glu8 Exendin-4 is a potent glucagon-like peptide-1 receptor (GLP-1-R) antagonist. Des His1, Glu8 Exendin-4 improves glucose homeostasis by regulating both insulin secretion and glucose production. Des His1, Glu8 Exendin-4 can be used for the research of type 2 diabetic and gastrointestinal .

HY-P10498

*[Des-Tyr1]-gamma-Endorphin*	Opioid Receptor	Neurological Disease
[Des-Tyr1]-gamma-Endorphin is a neuropeptide, which can be found in human cerebrospinal fluid. [Des-Tyr1]-gamma-Endorphin exhibits antidepressant efficacy, facilitates the extinction of active avoidance and attenuates the passive avoidance behavior in rats .

HY-P1366A

des-Gln14-Ghrelin TFA	GHSR	Metabolic Disease
des-Gln14-Ghrelin TFA is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca ²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM .

HY-P2658

*[Des-Tyr1]-Met-Enkephalin*	Neprilysin	Others
[Des-Tyr1]-Met-Enkephalin, a tetrapeptide, is a degradationproduct of enkephalins .

HY-P4459

*(Des-Gly2)-Exenatide*	GCGR	Metabolic Disease
(Des-Gly2)-Exenatide is a potential impurity of Exenatide (HY-13443).

HY-N11758

*5′-Des-O-methylharringtonine*	Others	Others
5′-Des-O-methylharringtonine is a nature product that could be isolated from Cephalotaxus harringtonia .

HY-P3583

*(Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken)*	GnRH Receptor	Others
Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken) is an active petide. (Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken) can be used for the research of various biochemical studies .

HY-P5518

*[Des-Arg10]-HOE I40*	Bradykinin Receptor	Inflammation/Immunology Endocrinology
[Des-Arg10]-HOE I40 is a potent bradykinin B1 receptor antagonist .

HY-W706908

Des(isopropylamino) atenolol diol-d5	Isotope-Labeled Compounds	Others
Des(isopropylamino) atenolol diol-d₅ is the deuterium labeled 2-(4-(2,3-Dihydroxypropoxy)phenyl)acetamide (Atenolol Impurity) (HY-Z7632).

HY-P4683A

*(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin acetate*	Vasopressin Receptor	Cardiovascular Disease
(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin is a potent vasopressin V1 receptor (VP V1R) antagonist. (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin significantly decreases the mean arterial pressure (MAP) in rats .

Cat. No.	Product Name	Target	Research Area

HY-P0298A

*[Des-Arg9]-Bradykinin acetate* 1 Publications Verification	Bradykinin Receptor	Inflammation/Immunology Endocrinology
[Des-Arg9]-Bradykinin acetate is a Bradykinin B₁ receptor agonist that displays selectivity for B₁ over B₂ receptors.

HY-P1526

*ANP [Des18-22] 4-23 amide (rat)*	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
ANP [Des18-22] 4-23 amide rat is a polypeptide fragment of rat atrial natriuretic peptide (ANP) that specifically binds NPR-C .

HY-P1366

des-Gln14-Ghrelin 1 Publications Verification	GHSR	Metabolic Disease
des-Gln14-Ghrelin is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca ²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM .

HY-P4463

*(Des-Pyr1)-LHRH*	GnRH Receptor	Others
(Des-Pyr1)-LHRH is a Polypeptide Internal Standard, identical to (Des-Pyr1)-GnRH, which can be identified through peptide screening. Peptide screening is a research tool that mainly collects active polypeptides via immunoassays. It can be applied to protein interaction, functional analysis, epitope screening, especially in the field of active molecule research and development. (Des-Pyr1)-LHRH can serve as an internal standard (ISTD) for mass spectrometry analysis .

HY-P0048

*(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH* 1 Publications Verification Surfagon	GnRH Receptor	Others
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon, Mwt 1167.34 Da) is an agonist of gonadotropin-releasing hormone (GnRH). (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH can be used as an internal standard for the LC-MS analysis of leuprorelide acetate. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH has potential applications in biochemical analysis and fertility .

HY-P4676

*Lys-(Des-Arg9,Leu8)-Bradykinin*	Bradykinin Receptor	Inflammation/Immunology
Lys-(Des-Arg9,Leu8)-Bradykinin is a selective bradykinin B1 receptor (BDKRB1) antagonist. Lys-(Des-Arg9,Leu8)-Bradykinin inhibits local inflammatory edema. Lys-(Des-Arg9,Leu8)-Bradykinin induces the production of systemic acute-phase proteins. Lys-(Des-Arg9,Leu8)-Bradykinin is applicable to research related to peptidoglycan-polysaccharide-induced acute arthritis .

HY-P1143A

*[Des-His1,Glu9]-Glucagon amide TFA*	GCGR	Metabolic Disease
[Des-His1,Glu9]-Glucagon amide TFA is a potent and peptide antagonist of the glucagon receptor, with a pA₂ of 7.2. [Des-His1,Glu9]-Glucagon amide TFA is potentially useful in the study of the pathogenesis of diabetes .

HY-103291

*Sar-[D-Phe8]-des-Arg9-Bradykinin*	Bradykinin Receptor	Inflammation/Immunology Endocrinology
Sar-[D-Phe8]-des-Arg9-Bradykinin is a agonist of B1 receptor. Sar-[D-Phe8]-des-Arg9-Bradykinin selectively amplifies the contractile response when incubation with human recombinant interleukin-1 β (IL-1 β) in rabbit aortic rings .

HY-P4409

*(Des-Ala3)-GHRP-2*	Peptides	Others
(Des-Ala3)-GHRP-2 is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P1143

*[Des-His1,Glu9]-Glucagon amide*	GCGR	Metabolic Disease
[Des-His1,Glu9]-Glucagon amide is a potent and peptide antagonist of the glucagon receptor, with a pA₂ of 7.2. [Des-His1,Glu9]-Glucagon amide is potentially useful in the study of the pathogenesis of diabetes .

HY-P4541

*(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14)*	Bombesin Receptor	Cancer
(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14) is a bombesin (BBN) antagonist and can be used for the research of cancer .

HY-P4397

*(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin*	Oxytocin Receptor	Endocrinology
(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin, an oxytocin receptor antagonist, abolishes oxytocin-enhanced inhibitory postsynaptic currents in CA1 pyramidal neurons .

HY-P2828

*[Des-Pro2]-Bradykinin*	Ser/Thr Protease Peptides	Others
[Des-Pro2]-Bradykinin is a protease inhibitor. [Des-Pro2]-Bradykinin prevents the degradation of methionine enkephalin .

HY-P4440

*(Des-Gly10,Des-Ser4,D-Leu6,Pro-NHEt9)-LHRH*	GnRH Receptor	Others
(Des-Gly10,Des-Ser4,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P3209

Des-Arg9-[Leu8]-Bradykinin acetate	Bradykinin Receptor	Inflammation/Immunology
Des-Arg9-[Leu8]-Bradykinin acetate is potent bradykinin receptor 1 (B1R) antagonist. Des-Arg9-[Leu8]-Bradykinin acetate can be used for renal fibrosis research .

HY-P11363

*(Des-Asp1,Ile8)-Angiotensin II*	Angiotensin Receptor	Cardiovascular Disease
(Des-Asp1,Ile8)-Angiotensin II is a peptide related to angiotensin II. (Des-Asp1,Ile8)-Angiotensin II can be used for studying the interaction between angiotensin II and its receptors .

HY-P5518A

*[Des-Arg10]-HOE I40 TFA*	Bradykinin Receptor	Inflammation/Immunology Endocrinology
[Des-Arg10]-HOE I40 TFA is a potent bradykinin B1 receptor antagonist .

HY-103295A

*Lys-[Des-Arg9]Bradykinin TFA*	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a K_i of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin TFA has low inhibitory activity on B2 receptors .

HY-P0298

*[Des-Arg9]-Bradykinin*	Bradykinin Receptor	Inflammation/Immunology Endocrinology
[Des-Arg9]-Bradykinin is a Bradykinin (B₁) receptor agonist that displays selectivity for B₁ over B₂ receptors.

HY-P4432

*(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon)*	GnRH Receptor	Endocrinology
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon) is a GnRH analog that induces ovulation and/or spawning in farmed fish .

HY-P4413

*(Des-Glu5)-ACTH (1-24) (human, bovine, rat)*	Androgen Receptor	Endocrinology
(Des-Glu5)-ACTH (1-24) (human, bovine, rat) is an analogue of Adrenocorticotropic hormone (ACTH; HY-106373). ACTH is a polypeptide tropic hormone produced by the anterior pituitary gland, regulating cortisol and androgen production .

HY-P4411

*(Des-acetyl)-α-MSH* Desacetyl-α-MSH	Peptides	Others
(Des-acetyl)-α-MSH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4504

*(Des-Thr7)-Glucagon*	Peptides	Others
(Des-Thr7)-Glucagon is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4441

*(Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH*	GnRH Receptor	Others
(Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P11361

Des B30 Insulin	Peptides	Metabolic Disease
Des B30 Insulin is a bioactive insulin analogue lacking the B30 amino acid residue. Des B30 Insulin can be used for the study of diabetes .

HY-P4493

*(Des-Ser3)-ACTH (1-24) (human, bovine, rat)*	Peptides	Others
(Des-Ser3)-ACTH (1-24) (human, bovine, rat) is a peptide analog of the adrenocorticotropic hormone (ACTH). ACTH stimulates the production of cortisol .

HY-103295

*Lys-[Des-Arg9]Bradykinin*	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
Lys-[Des-Arg9]Bradykinin, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a K_i of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin has low inhibitory activity on B2 receptors .

HY-P4467

*(Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH* (Des-Pyr1)-Leuprolide	GnRH Receptor	Others
(Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P5713

Des(8-14)brevinin-1PMa	Bacterial	Infection
Des(8-14)brevinin-1PMa is a host-defense peptide that exhibits antimicrobial activity against Staphylococcus aureus and Echerichia coli. Des(8-14)brevinin-1PMa also shows hemolytic activity .

HY-P3608

*[Des-His1,Glu9] Glucagon*	GCGR	Metabolic Disease
[Des-His1,Glu9] Glucagon is a potent glucagon receptor system peptide antagonist. [Des-His1,Glu9] Glucagon enhances the glucose-stimulated release of insulin from pancreatic islet cells. [Des-His1,Glu9] Glucagon can be used to research diabetes .

HY-P3542

Des His1, Glu8 Exendin-4	GCGR	Metabolic Disease
Des His1, Glu8 Exendin-4 is a potent glucagon-like peptide-1 receptor (GLP-1-R) antagonist. Des His1, Glu8 Exendin-4 improves glucose homeostasis by regulating both insulin secretion and glucose production. Des His1, Glu8 Exendin-4 can be used for the research of type 2 diabetic and gastrointestinal .

HY-P10498

*[Des-Tyr1]-gamma-Endorphin*	Opioid Receptor	Neurological Disease
[Des-Tyr1]-gamma-Endorphin is a neuropeptide, which can be found in human cerebrospinal fluid. [Des-Tyr1]-gamma-Endorphin exhibits antidepressant efficacy, facilitates the extinction of active avoidance and attenuates the passive avoidance behavior in rats .

HY-P1366A

des-Gln14-Ghrelin TFA	GHSR	Metabolic Disease
des-Gln14-Ghrelin TFA is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca ²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM .

HY-P2658

*[Des-Tyr1]-Met-Enkephalin*	Neprilysin	Others
[Des-Tyr1]-Met-Enkephalin, a tetrapeptide, is a degradationproduct of enkephalins .

HY-P4459

*(Des-Gly2)-Exenatide*	GCGR	Metabolic Disease
(Des-Gly2)-Exenatide is a potential impurity of Exenatide (HY-13443).

HY-P3583

*(Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken)*	GnRH Receptor	Others
Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken) is an active petide. (Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken) can be used for the research of various biochemical studies .

HY-P5518

*[Des-Arg10]-HOE I40*	Bradykinin Receptor	Inflammation/Immunology Endocrinology
[Des-Arg10]-HOE I40 is a potent bradykinin B1 receptor antagonist .

HY-P3817

Des-[Gly77,His78] Myelin Basic Protein (68-84), bovine	Peptides	Neurological Disease
Des-[Gly77,His78] Myelin Basic Protein (68-84) is a 68-84 sequence fragment of guinea pig myelin basic protein (GPMBP). Des-[Gly77,His78] Myelin Basic Protein (68-84) regulates functionally diverse encephalitogenic and proliferative activities of experimental autoimmune encephalomyelitis (EAE)-associated T cells .

HY-P4683A

*(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin acetate*	Vasopressin Receptor	Cardiovascular Disease
(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin is a potent vasopressin V1 receptor (VP V1R) antagonist. (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin significantly decreases the mean arterial pressure (MAP) in rats .

HY-P4683

*(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin*	Vasopressin Receptor	Cardiovascular Disease
(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin is a potent vasopressin V1 receptor (VP V1R) antagonist. (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin significantly decreases the mean arterial pressure (MAP) in rats .

HY-P4414

*(Des-Bromo)-Neuropeptide B (1-23) (human)*	Orphan Receptor Neuropeptide B/W Receptor	Neurological Disease
(Des-Bromo)-Neuropeptide B (1-23) (human) is an orphan G-protein coupled receptor agonist with K_is of 1.2 nM and 341 nM for GPR7 (NPBW1) and GPR8 (NPBW2), respectively .

HY-P4456

*(Des-His6)-ACTH (1-24) (human, bovine, rat)*	Adrenergic Receptor	Endocrinology
(Des-His6)-ACTH (1-24) (human, bovine, rat) is an analogue of Adrenocorticotropic hormone (ACTH; HY-106373). ACTH is a polypeptide tropic hormone produced by the anterior pituitary gland, regulating cortisol and androgen production .

HY-P3006

Des-Leu10-angiotensin I	Drug Metabolite	Cardiovascular Disease
Des-Leu10-angiotensin I is a nonapeptide that inhibits rabbit lung angiotensin-converting enzyme peptidyl-dipeptide hydrolase with a K_i value of 31 μM, which is generated from angiotensin I by the action of carboxypeptidase-like activities residing in the human platelet and mast cell .

HY-P4502

*(Des-Thr5)-Glucagon*	Peptides	Others
(Des-Thr5)-Glucagon is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4442

*(Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH*	GnRH Receptor	Others
(Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4447

*(Des-Gly10,D-Pyr1,D-Leu6,Pro-NHEt9)-LHRH*	GnRH Receptor	Others
(Des-Gly10,D-Pyr1,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4445

*(Des-Gly10,D-Leu6,Orn8,Pro-NHEt9)-LHRH*	GnRH Receptor	Others
(Des-Gly10,D-Leu6,Orn8,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P2088

TANDEM Des-N-tetramethyltriostin A	Antibiotic	Cancer
TANDEM (Des-N-tetramethyltriostin A) is a synthetic antibiotic drug that has the activity of inhibiting the growth of tumor cells. TANDEM can be used in combination with chemotherapy to enhance the inhibitory effect. TANDEM has shown significant inhibitory effects on a variety of cancer cell lines in in vitro experiments. The structure of TANDEM allows it to effectively target tumor cells during the inhibition process. TANDEM's mechanism of action involves interfering with cell proliferation and survival pathways .

HY-P4676A

*Lys-(Des-Arg9,Leu8)-Bradykinin TFA*	Bradykinin Receptor	Inflammation/Immunology
Lys-(Des-Arg9,Leu8)-Bradykinin TFA is a selective bradykinin B1 receptor (BDKRB1) antagonist. Lys-(Des-Arg9,Leu8)-Bradykinin TFA inhibits local inflammatory edema. Lys-(Des-Arg9,Leu8)-Bradykinin TFA induces the production of systemic acute-phase proteins. Lys-(Des-Arg9,Leu8)-Bradykinin TFA is applicable to research related to peptidoglycan-polysaccharide-induced acute arthritis .

HY-P11463

Des-threoninol-octreotide	Somatostatin Receptor	Metabolic Disease
Des-threoninol-octreotide (Compound 13) is a Somatostatin analog. Des-threoninol-octreotide inhibits cloned somatostatin receptors with IC₅₀ values of 13.62 nM, 10.63 nM, 10.95 nM for mSSTR2b, rSSTR5 and hSSTR5, respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-121309

Doxorubicinone 2 Publications Verification Adriamycin aglycone; Adriamycinone	Quinones Structural Classification Classification of Application Fields Anthraquinones Endogenous metabolite Disease Research Fields Source Classification Cancer	NF-κB TNF Receptor Interleukin Related Drug Derivative
Doxorubicinone (Adriamycin aglycone) is the aglycone of the antibiotic Doxorubicin (HY-15142A), i.e., its sugar-free parent nucleus structure. Doxorubicinone does not induce DNA damage or bind to RelA, but still downregulates the expression of pro-inflammatory cytokines (such as TNF, IL-12, etc.) regulated by the NF-κB pathway. Doxorubicinone can be used in sepsis-related research .

HY-N9542

Dimethyl Citric acid 1 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Plants Actinidiaceae Disease Research Fields Actinidia arguta (Sieb. & Zucc) Planch. ex Miq. Source Classification	Others
Dimethylurea/citric acid is a highly efficient deep eutectic solvent (DES). Dimethylurea/citric acid can be used as a catalyst and a green reaction medium for the synthesis of bis(indolyl)methanes, quinolines and aryl-4, 5-diphenyl-1H-imidazoles.

HY-N11758

*5′-Des-O-methylharringtonine*	Cephalotaxus harringtonia (Knight ex J.Forbes) K.Koch Alkaloids Other Alkaloids Taxaceae Plants Source Classification	Others
5′-Des-O-methylharringtonine is a nature product that could be isolated from Cephalotaxus harringtonia .

HY-N17355

Des-N-methylnoracronycine	Structural Classification Alkaloids Glycosmis arborea (Retz.) Corrêa Other Alkaloids Rutaceae Plants Source Classification	Biochemical Assay Reagents
Des-N-methylnoracronycine is an acridone alkaloid found in the root bark of Glycosmis pentaphylla (Retz.) Correa. Des-N-methylnoracronycine has antitumor and platelet aggregation inhibitory activities .

HY-N16393

(-)-Mitorubrinol Mitorubrinol	Microorganisms Phenols Polyphenols Source Classification	Others
(-)-Mitorubrinol is found in the marine-derived Penicillium purpurogenum G59 strain induced by diethyl sulfate (DES). (-)-Mitorubrinol exhibits inhibitory effects on K562, HL-60, HeLa, and BGC-823 cancer cell lines .

Cat. No.	Product Name	Chemical Structure

HY-122402S

Umirolimus-d5
Umirolimus-d₅ is the deuterium labeled Umirolimus (HY-122402). Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used agent-eluting stent (DES) applications .

HY-132795S

Des(1-cyclohexanol) Venlafaxine-d6
Des(1-cyclohexanol) Venlafaxine-d₆ is the deuterium labeled Des(1-cyclohexanol) Venlafaxine .

HY-W706908

Des(isopropylamino) atenolol diol-d5
Des(isopropylamino) atenolol diol-d₅ is the deuterium labeled 2-(4-(2,3-Dihydroxypropoxy)phenyl)acetamide (Atenolol Impurity) (HY-Z7632).

HY-141757S

Des-p-fluorobenzyl mosapride-d5
Des-p-fluorobenzyl mosapride-d₅ is the deuterium labeled Des-p-fluorobenzyl mosapride .

HY-132684S

*7-Benzyloxy-N-des[[2-(2-hydroxy)ethoxy]ethyl] Quetiapine-d8*
7-Benzyloxy-N-des[[2-(2-hydroxy)ethoxy]ethyl] Quetiapine-d₈ is the deuterium labeled 7-Benzyloxy-N-des[[2-(2-hydroxy)ethoxy]ethyl] Quetiapine .

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