4 Results for "

Endosomolytic peptides

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "Endosomolytic peptides" in MCE Product Catalog:

L17E
L17E
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Cat. No.: HY-P4121
CAS No.: 1898254-09-5
Target:  

Potassium Channel

Research Areas:  

Inflammation/Immunology Cancer

L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles .
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EB1 peptide
EB1 peptide
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Cat. No.: HY-P4118
CAS No.: 952754-66-4
Synonyms: Penetrating analog
Target:  

Amino Acid Derivatives Peptide-Drug Conjugates (PDCs)

Research Areas:  

Others

EB1 peptide (Penetrating analog) is an endosomolytic agent and siRNA delivery agent. EB1 peptide forms an amphipathic alpha helix upon protonation in early-late endosomes, drives endosomal membrane permeabilization, and enables endocytosed siRNA escape into the cytosol. EB1 peptide facilitates biologically active siRNA cellular uptake and targeted gene silencing. EB1 peptide forms complexes with siRNA. EB1 peptide can be used for drug delivery research .
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L17E-OH
L17E-OH
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Cat. No.: HY-169756
CAS No.: 2305578-13-4
Target:  

Peptides

Research Areas:  

Others

L17E-OH is a derived peptide of L17E, an endosomolytic peptide, a cationic amphipathic peptide with specific membrane lytic activity against late endosomes (Les) .
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DOPE-PEG2000-EB1
DOPE-PEG2000-EB1
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Cat. No.: HY-187478A
Synonyms: DOPE-PEG2000-Mal-Cys-LIRLWSHLIHIWFQNRRLKWKKK
Target:  

Biochemical Assay Reagents

Research Areas:  

Others

DOPE-PEG2000-EB1 (DOPE-PEG2000-Mal-Cys-LIRLWSHLIHIWFQNRRLKWKKK) is an amphiphilic lipid-PEG-peptide conjugate composed of DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the EB1 peptide (a penetratin analog). EB1 peptide is an endosomolytic agent that forms an amphipathic alpha helix upon protonation in endosomes, driving endosomal membrane permeabilization. DOPE-PEG2000-EB1 is used for intracellular delivery of nucleic acids (e.g., siRNA) and other macromolecular therapeutics.
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