DOPE-PEG2000-EB1

DOPE-PEG2000-EB1: functionalization of liposomes and nanoparticles for enhanced intracellular delivery of siRNA, nucleic acids, and macromolecular drugs, particularly to overcome the endosomal escape barrier.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two oleoyl chains that anchors into lipid bilayers and promotes membrane destabilization and fusion under acidic conditions;
(2) PEG2000; a hydrophilic polymer that provides steric stabilization, reduces opsonization, and extends circulation time;
(3) EB1 peptide; a penetratin analog and endosomolytic agent that forms an amphipathic alpha helix upon protonation in early-to-late endosomes, permeabilizing endosomal membranes and enabling encapsulated cargo (e.g., siRNA) to escape into the cytosol for effective gene silencing.

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