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44 Results for "
Farnesyl diphosphate
" in MedChemExpress (MCE) Product Catalog:
Products (44)
44 Results for "Farnesyl diphosphate" in MCE Product Catalog:
10
10 Publications Verification
Synonyms: Alendronate; MK 217; G-704650 Adronat
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Alendronate (sodium hydrate) is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM.
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6 Cited Publications
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YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent . YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .
1
1 Cited Publications
Synonyms: Farnesyl diphosphate ammonium
1
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Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene in the cholesterol biosynthesis pathway . Lapaquistat acetate is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage. Lapaquistat acetate is used for hypercholesterolemia and mevalonate kinase deficiency (MKD) research .
Cat. No.: HY-113037
CAS No.: 13058-04-3
Synonyms: (E/Z)-Farnesyl diphosphate
Category:
Human Gut Microbiota Metabolites Natural Products Microorganisms Neurological Disease Endogenous metabolite Disease Research Fields
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Cat. No.: HY-N12804
CAS No.: 19435-97-3
Synonyms: (-)-Torreyol
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Cat. No.: HY-113037CS
Synonyms: Farnesyl diphosphate-d2 triammonium
BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL) .
Cat. No.: HY-113037B
CAS No.: 372-97-4
Synonyms: Farnesyl diphosphate
Research Areas:
Farnesyl pyrophosphate is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases.
MMV019313 is a potent, non-bisphosphonate inhibitor of farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) with an IC50 of 0.82 µM. MMV019313 has activity against P. falciparum (Parasite) .
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Incadronic acid inhibits growth of Dictyostelium discoideum with an IC50 of 1.6 μM. Incadronic acid binds the farnesyl diphosphate synthase (FPPS) in Leishmania major with the Ki of 23 nM. Incadronic acid inhibits the bone resorption and reduces bone loss, that can be used in osteoporosis research. Incadronic acid inhibits the proliferation of cells RAW264.7, PC-3 and MCF-7 with IC50 of 48 to 228.6 µM .
Cat. No.: HY-B0631S
CAS No.: 1035437-39-8
Cat. No.: HY-116254
CAS No.: 160141-08-2
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L-739750 is a selective protein farnesyltransferase (PFTase) inhibitor (IC50: 0.4 nM). PFTase utilizes farnesyl diphosphate to farnesylate the cysteine residue of protein substrates having a C-terminal CAAX motif. L-739750 is a selective CAAX peptidomimetic .
Cat. No.: HY-100313
CAS No.: 182959-28-0
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Cat. No.: HY-126825
CAS No.: 427899-21-6
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NE21650 potently inhibits farnesyl diphosphate (FPP) synthase. NE21650 is a weak inhibitor of isopentenyl diphosphate (IPP) isomerase. NE21650 is a potent inhibitor of protein prenylation in osteoclasts and macrophages and bone resorption in vitro .
Cat. No.: HY-E71065A
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(2Z,6Z)-Farnesyl diphosphate synthase (EC 2.5.1.92) specifically forms (2Z,6Z)-farnesyl diphosphate via neryl diphosphate and isopentenyl diphosphate.
Cat. No.: HY-11101R
CAS No.: 121268-17-5
Synonyms: Alendronate (Standard); MK 217 (Standard); G-704650 Adronat (Standard)
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Alendronate (sodium hydrate) (Standard) is the analytical standard of Alendronate (sodium hydrate). This product is intended for research and analytical applications. Alendronate (sodium hydrate) is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM.
Cat. No.: HY-E72003
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7-Epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing] (EC 4.2.3.142) is a lyase that can convert (2E,6E)-farnesyl diphosphate into 7-epizingiberene and diphosphate.
Cat. No.: HY-E71065
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(2Z,6E)-Farnesyl diphosphate synthaserequires Mg2+ or Mn2+ for activity.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
