124351-85-5
124351-85-5
Chemical Structure
Incadronic acid
- CAS 番号: 124351-85-5
- Formula:C8H19NO6P2
- Molecular Weight:287.19
IUPAC Name: ((cycloheptylamino)methylene)bis(phosphonic acid)
InChIKey: LWRDQHOZTAOILO-UHFFFAOYSA-N
SMILES: O=P(O)(C(P(O)(O)=O)NC1CCCCCC1)O
Biological Activity: Incadronic acid inhibits growth of Dictyostelium discoideum with an IC50 of 1.6 μM. Incadronic acid binds the farnesyl diphosphate synthase (FPPS) in Leishmania major with the Ki of 23 nM. Incadronic acid inhibits the bone resorption and reduces bone loss, that can be used in osteoporosis research. Incadronic acid inhibits the proliferation of cells RAW264.7, PC-3 and MCF-7 with IC50 of 48 to 228.6 µM[1].
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Incadronic acid | 98.03% | Incadronic acid inhibits growth of Dictyostelium discoideum with an IC50 of 1.6 μM. Incadronic acid binds the farnesyl diphosphate synthase (FPPS) in Leishmania major with the Ki of 23 nM. Incadronic acid inhibits the bone resorption and reduces bone loss, that can be used in osteoporosis research. Incadronic acid inhibits the proliferation of cells RAW264.7, PC-3 and MCF-7 with IC50 of 48 to 228.6 µM. | ||||||||||||||||||||
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