5352-53-4
5352-53-4
Chemical Structure
BPH-1358
Synonym(s): NSC50460
- CAS No.: 5352-53-4
- Formula:C32H30Cl2N6O2
- Molecular Weight:601.53
IUPAC Name: N4,N4'-bis(3-(4,5-dihydro-1H-imidazol-2-yl)phenyl)-[1,1'-biphenyl]-4,4'-dicarboxamide dihydrochloride
InChIKey: ASVCJNSPDDRTOQ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2=CC=C(C(NC3=CC=CC(C4=NCCN4)=C3)=O)C=C2)C=C1)NC5=CC=CC(C6=NCCN6)=C5.[H]Cl.[H]Cl
Biological Activity: BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BPH-1358 | 98.33% | BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL). | ||||||||||||||||||||
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Imidocarb dipropionate | 99.94% | Imidocarb dipropionate is a potent antiprotozoal agent. Imidocarb dipropionate is active against the parasite B. bovis with an IC50 of 87 μg/mL. | ||||||||||||||||||||
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BPH-1358 free base | BPH-1358 free base (NSC50460 free base) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL). | |||||||||||||||||||||
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NSC-60339 (Standard) | ≥98% | NSC-60339 (Standard) is the analytical standard of NSC-60339. This product is intended for research and analytical applications. NSC-60339, an efflux pump inhibitor and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent. | ||||||||||||||||||||
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p32 Inhibitor M36 | 98.55% | p32 inhibitor M36 (M36) is a p32 mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1. | ||||||||||||||||||||
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Imidocarb (Standard) | ≥98% | Pargyline (hydrochloride) (Standard) is the analytical standard of Pargyline (hydrochloride). This product is intended for research and analytical applications. Pargyline hydrochloride is an irreversible monoamine oxidase (MAO) inhibitor with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively. Pargyline hydrochloride has antihypertensive and anticancer activities. Pargyline (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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NCI-B16 | 99.25% | NCI-B16 is a small molecule RNA binder obtained through RNA-small molecule interaction screening. NCI-B16 interacts with RNA motifs under competitive conditions. NCI-B16 is used for RNA-small molecule interaction studies. |
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NSC 104999 | NSC 104999 is a Grb7 SH2 domain binder with moderate affinity (Kd = 32.3 μM). NSC 104999 exhibits anticancer activity against breast cancer. | |||||||||||||||||||||
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NSC 57148 | NSC 57148 is a selective Grb7 SH2 domain antagonist with an IC50 value of 1.1 μM. NSC 57148 reduces cancer cell proliferation and migration. NSC 57148 is promising for research of Grb7-overexpressing malignancies such as breast and pancreatic cancers. | |||||||||||||||||||||
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GW4869 | 95.12% | GW4869 is a noncompetitive neutral sphingomyelinase (N-SMase) inhibitor with an IC50 of 1 μM. GW4869 is an inhibitor of exosome biogenesis/release. | ||||||||||||||||||||
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N4,N4'-Di(pyridin-4-yl)-[1,1'-biphenyl]-4,4'-dicarboxamide | N4,N4'-Di(pyridin-4-yl)-[1,1'-biphenyl]-4,4'-dicarboxamide is a metal-organic framework (MOF). | |||||||||||||||||||||
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