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Results for "

GDP-bound KRASG12D

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

1

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Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-176419
    KRAS inhibitor-42

    		Ras Cancer
    KRAS inhibitor-42 (compound 8) is a potent USP7 inhibitor. KRAS inhibitor-42 has high affinity against GDP-bound KRASG12D with a Ki of 2.7 μM .
    KRAS inhibitor-42
  • HY-180200
    RNK08954

    		Ras ERK Cancer
    RNK08954 is an orally active KRASG12D inhibitor with a Kd of 0.0395 nM. RNK08954 selectively binds the inactive GDP-bound KRASG12D form, suppresses downstream KRAS-mediated signaling pathways p-ERK1/2 experssion. RNK08954 inhibits KRASG12D-mutant cell proliferation, induces G0-G1 cell cycle arrest, and inhibits tumor growth in mouse xenograft models. RNK08954 can be used for the research of non-small cell lung cancer, pancreatic ductal adenocarcinoma .
    RNK08954
  • HY-184010
    KRASG12D-IN-8

    		Ras ERK Cancer
    KRASG12D-IN-8 is an orally active KRAS G12D inhibitor, with a Kd value of 0.003 nM for KRAS G12D and 0.024 nM for KRAS G12V. KRASG12D-IN-8 inhibits the activity of phosphorylated ERK in KRAS-mutated cells. KRASG12D-IN-8 induces tumor regression in ovarian cancer xenograft mouse models. KRASG12D-IN-8 can be used for the research of KRAS-mutated cancers .
    KRASG12D-IN-8

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