3032602-44-8
Chemical Structure
RNK08954
- CAS No.: 3032602-44-8
- Formula:C36H36F2N6O3
- Molecular Weight:638.71
InChIKey: XOTUZSJOOFCTPU-UHFFFAOYSA-N
SMILES: C#CC1=C(C=CC2=CC(O)=CC(C3=NC(OC)=C4C(N5CC6CCC(N6)C5)=NC(OCC7(CC7)CN8CC9CC9C8)=NC4=C3F)=C21)F
Biological Activity: RNK08954 is an orally active KRASG12D inhibitor with a Kd of 0.0395 nM. RNK08954 selectively binds the inactive GDP-bound KRASG12D form, suppresses downstream KRAS-mediated signaling pathways p-ERK1/2 experssion. RNK08954 inhibits KRASG12D-mutant cell proliferation, induces G0-G1 cell cycle arrest, and inhibits tumor growth in mouse xenograft models. RNK08954 can be used for the research of non-small cell lung cancer, pancreatic ductal adenocarcinoma[1].
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RNK08954 | RNK08954 is an orally active KRASG12D inhibitor with a Kd of 0.0395 nM. RNK08954 selectively binds the inactive GDP-bound KRASG12D form, suppresses downstream KRAS-mediated signaling pathways p-ERK1/2 experssion. RNK08954 inhibits KRASG12D-mutant cell proliferation, induces G0-G1 cell cycle arrest, and inhibits tumor growth in mouse xenograft models. RNK08954 can be used for the research of non-small cell lung cancer, pancreatic ductal adenocarcinoma. | |||||||||||||||||||||
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Keywords
