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Results for "

GFRAL

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

3

Inhibitory Antibodies

12

Recombinant Proteins

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99241
    Ponsegromab
    1 Publications Verification

    PF 06946860

    		 TGF-beta/Smad Cancer
    Ponsegromab is a Growth differentiation factor 15 (GDF15) inhibitor with human, cynomolgus monkey, and mouse target IC50 values of 0.123 nM, 0.053 nM, and 0.102 nM, respectively . Ponsegromab acts as a chemosensitizer, increases intracellular reactive oxygen species, reduces glutathione levels . Ponsegromab can be used for the research of oxaliplatin-resistant colorectal cancer .
    Ponsegromab
  • HY-W587486
    N-Acetyltaurine

    		Endogenous Metabolite Bacterial Neurological Disease
    N‑acetyltaurine is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N‑acetyltaurine supports bacterial growth as a sole fixed nitrogen or carbon source. N‑acetyltaurine buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N‑acetyltaurine reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N‑acetyltaurine can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes .
    N-Acetyltaurine
  • HY-W587486R
    N-Acetyltaurine (Standard)

    		Reference Standards Endogenous Metabolite Bacterial Neurological Disease
    N-Acetyltaurine (Standard) is the analytical standard of N-Acetyltaurine (HY-W587486). This product is intended for research and analytical applications. N‑acetyltaurine is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N‑acetyltaurine supports bacterial growth as a sole fixed nitrogen or carbon source. N‑acetyltaurine buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N‑acetyltaurine reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N‑acetyltaurine can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes .
    N-Acetyltaurine (Standard)
  • HY-RS05390
    GFRAL Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    GFRAL Human Pre-designed siRNA Set A contains three designed siRNAs for GFRAL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GFRAL Human Pre-designed siRNA Set A
    GFRAL Human Pre-designed siRNA Set A
  • HY-RS23795
    Gfral Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Gfral Rat Pre-designed siRNA Set A contains three designed siRNAs for Gfral gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Gfral Rat Pre-designed siRNA Set A
    Gfral Rat Pre-designed siRNA Set A
  • HY-RS17340
    Gfral Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Gfral Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gfral gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Gfral Mouse Pre-designed siRNA Set A
    Gfral Mouse Pre-designed siRNA Set A
  • HY-P992393
    JMT203

    		TGF-β Receptor Cancer
    JMT203 is a monoclonal antibody against GFRAL and a body weight gain inducer. JMT203 induces early-onset, sustained and progressive body weight gain in cancer cachexia. JMT203 can be used for research related to cancer cachexia .
    JMT203

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