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Results for "

GT1b

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Biochemical Assay Reagents (1) DNA/RNA Synthesis (2) EGFR (2) ERK (2) HCV (23) HCV Protease (10) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (2) mTOR (2) Ras (1) Reference Standards (2) SARS-CoV (4) TET Protein (2) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (3) Infection (27) Inflammation/Immunology (6) Metabolic Disease (4) Neurological Disease (5)

Inhibitors & Agonists

Peptides

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15298

Grazoprevir 25+ Cited Publications MK-5172	HCV Protease HCV SARS-CoV	Infection
Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively ^[1] . Grazoprevir inhibits SARS-CoV-2 3CL ^pro activity .

HY-131686

*Ganglioside GT1b* (bovine) ammonium**	Akt mTOR EGFR ERK	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Ganglioside GT1b (bovine) ammonium is a member of the ganglioside family. Ganglioside GT1b (bovine) ammonium acts as a protective signal against nerve injury-induced spinal synapse elimination. Ganglioside GT1b (bovine) ammonium induces HA synthesis and the phosphorylation of Akt/mTOR in orbital fibroblasts. Ganglioside GT1b (bovine) ammonium enhances porcine oocyte maturation and induce activation of EGFR and *ERK1/2* signaling. Ganglioside GT1b (bovine) ammonium is a putative host cell receptor for the Merkel cell polyomavirus. Ganglioside GT1b (bovine) ammonium can be used for the researches of cancer, infection, immunology, endocrinology and neurological disease, such as Thyroid eye disease ^[1] .

HY-15602B

Ledipasvir D-tartrate Maximum Cited Publications 31 Publications Verification GS-5885 D-tartrate	HCV	Infection
Ledipasvir D-tartrate is an inhibitor of the hepatitis C virus NS5A, with EC₅₀ values of 34 pM against GT1a and 4 pM against GT1b replicon.

HY-15602A

Ledipasvir (acetone) Maximum Cited Publications 31 Publications Verification GS-5885 (acetone)	HCV	Infection
Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC₅₀ values of 34 pM against GT1a and 4 pM against GT1b replicon.

HY-15298A

Grazoprevir potassium salt 25+ Cited Publications MK-5172 potassium salt	HCV HCV Protease SARS-CoV	Infection
Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively ^[1] . Grazoprevir potassium salt inhibits SARS-CoV-2 3CL ^pro activity .

HY-P11094

Tet1-Cys peptide	TET Protein	Neurological Disease
Tet1-Cys peptide is a peptide with the sequence HLNILSTLWKYRC. Tet1 (HLNILSTLWKYR) (HY-P10998) can specifically bind to the neuronal ganglioside receptor *GT1b, possessing neuronal targeting capabilities. The Tet1-Cys* peptide sequence has an added Cys, which can be used for drug conjugation for research on drug delivery ^[1].

HY-124191

Ravidasvir hydrochloride PPI-668 hydrochloride	HCV	Infection
Ravidasvir hydrochloride (PPI-668 hydrochloride) is a pan-genotypic inhibitor for hepatitis C virus (HCV) NS5A protein. Ravidasvir hydrochloride inhibits the replication of HCV, with EC₅₀ of 0.12, 0.01 and 1.14 nM, for HCV gt-1a, gt-1b, and gt-3a replicons, respectively. Ravidasvir hydrochloride exhibits good pharmacokinetic characters in rats ^[1].

HY-101634

ABT-072	HCV	Infection
ABT-072 is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a *EC₅₀=1 nM; HCV GT1b* EC₅₀=0.3 nM) ^[1] .

HY-15298B

Grazoprevir hydrate 25+ Cited Publications MK-5172 hydrate	HCV HCV Protease SARS-CoV	Infection
Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively ^[1] . Grazoprevir hydrate inhibits SARS-CoV-2 3CL ^pro activity .

HY-P10998

Tet1 peptide	TET Protein	Neurological Disease
Tet1 peptide is a peptide that specifically binds to neurons. Tet1 peptide binds to *GT1B* ganglioside and trisialoganglioside clostridial toxin receptor on the surface of neuronal cells, and can be used in peptide conjugation and drug delivery research ^[1] .

HY-131686A

*Ganglioside GT1b* (porcine) ammonium**	Akt mTOR EGFR ERK	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Ganglioside GT1b (porcine) ammonium is a member of the ganglioside family. Ganglioside GT1b (porcine) ammonium acts as a protective signal against nerve injury-induced spinal synapse elimination. Ganglioside GT1b (porcine) ammonium induces HA synthesis and the phosphorylation of Akt/mTOR in orbital fibroblasts. Ganglioside GT1b (porcine) ammonium enhances porcine oocyte maturation and induces activation of EGFR and *ERK1/2* signaling. Ganglioside GT1b (porcine) ammonium is a putative host cell receptor for the Merkel cell polyomavirus. Ganglioside GT1b (porcine) ammonium can be used for the researches of cancer, infection, immunology, endocrinology and neurological disease, such as Thyroid eye disease ^[1] .

HY-101634A

ABT-072 potassium trihydrate	HCV	Infection
ABT-072 (potassium trihydrate) is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a *EC₅₀=1 nM; HCV GT1b* EC₅₀=0.3 nM) ^[1] .

HY-W714151

Ganglioside ga1 Gg4cer; Asialoganglioside gm1; Asialo gm1, Gangliotetraosylceramide; Asialo ganglioside gm1a [...]; Ganglio-n-tetraosylceramide; Asialo gm1 ganglioside; Asialoganglioside GT1b	Biochemical Assay Reagents	Metabolic Disease
Ganglioside ga1 (Gg4cer; Asialoganglioside gm1; Asialo gm1, Gangliotetraosylceramide; Asialo ganglioside gm1a [...]; Ganglio-n-tetraosylceramide; Asialo gm1 ganglioside; Asialoganglioside gt1b) is an ester product.

HY-15602D

Ledipasvir (diacetone) GS-5885 (diacetone)	HCV	Infection
Ledipasvir diacetone (GS-5885 diacetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC₅₀ values of 34 pM against GT1a and 4 pM against GT1b replicon.

HY-15602AS

Ledipasvir-d6 hydrochloride GS-5885-d6 hydrochloride	HCV Isotope-Labeled Compounds	Infection
Ledipasvir-d₆ hydrochloride is deuterated labeled Ledipasvir acetone (HY-15602A). Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC₅₀ values of 34 pM against GT1a and 4 pM against GT1b replicon.

HY-175073

*Ganglioside GT1b* (bovine) trisodium**	Toll-like Receptor (TLR) Interleukin Related	Neurological Disease Inflammation/Immunology
Ganglioside GT1b bovine trisodium is a trisialic acid ganglioside. Ganglioside GT1b bovine trisodium binds to botulinum toxin type A (BTxA), BTxA heavy chain, and tetanus toxin with IC₅₀ values of 11, 0.74, and 7.2 μM, respectively. Ganglioside GT1b bovine trisodium acts as a TLR2 agonist, leading to microglial activation, increased expression of pro-inflammatory factors, and increased pain sensitivity in spinal microglia. Ganglioside GT1b bovine trisodium also reduces the production of IL-6, IL-10, IgG, IgM, and IgA in human peripheral blood mononuclear cells (PBMCs). Ganglioside GT1b bovine trisodium increases extracellular glutamate levels in neural cell models. Ganglioside GT1b bovine trisodium has potential applications in research on immune system diseases and nervous system diseases ^[1] .

HY-111087

AZD-7295	HCV Protease	Infection Inflammation/Immunology
AZD-7295 is a HCV NS5A protein inhibitor, with an EC₅₀ of 7 nM for GT-1b replicon ^[1] .

HY-179818

*C18:0 GT1b* (d18:1/18:0) triammonium**	Others	Metabolic Disease
C18:0 GT1b (d18:1/18:0) (triammonium) is a glycosphingolipid.

HY-147763

HCV-IN-39	HCV	Infection
HCV-IN-39 (Compound 18a) is a potent hepatitis C virus (HCV) nucleoside inhibitor with EC₅₀ values of 0.644, 0.952 and 0.154 μM against GT1a, GT1b and GT1b CES1 replicons ^[1].

HY-147764

HCV-IN-40	HCV	Infection
HCV-IN-40 (Compound 18c) is a potent, orally active hepatitis C virus (HCV) nucleoside inhibitor with EC₅₀ values of 0.259, 0.434 and 0.069 μM against GT1a, GT1b and GT1b CES1 replicons ^[1].

HY-150760

GSK5852 GSK2485852	HCV	Inflammation/Immunology
GSK5852 (GSK2485852) is an HCV NS5B polymerase inhibitor, with an IC₅₀ value of 50 nM. GSK5852 displays antiviral activity and inhibits HCV with EC₅₀s of 3.0 nM (genotype 1a, GT1a) and 1.7 nM (GT1b), respectively ^[1] .

HY-131905S

BMS-986144	Isotope-Labeled Compounds HCV Protease HCV	Infection Inflammation/Immunology Cancer
BMS-986144 is a third-generation, pan-genotype (GT) NS3/4A protease inhibitor. BMS-986144 inhibits HCV replicon with EC₅₀s of 2.3, 0.7, 1.0, 12, 8.0, and 5.8 nM for GT-1a, GT-1b, GT-2a, GT-3a, 1a R155X, and 1b D168V, respectively. BMS-986144 has the potential for the research of HCV infection ^[1].

HY-15298C

Grazoprevir sodium salt MK-5172 sodium salt	HCV HCV Protease SARS-CoV	Infection
Grazoprevir sodium salt (MK-5172 sodium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively ^[1] . Grazoprevir sodium salt inhibits SARS-CoV-2 3CL ^pro activity .

HY-19932

MK-2748	HCV Protease HCV	Infection
MK-2748 is a hepatitis C virus (HCV) NS3/4a protease inhibitor. MK-2748 exhibits broad-spectrum and potent antiviral activity, with nanomolar-level activity against all genotypes (gt1a-gt6) (IC₅₀ < 0.115 nM), showing only slightly weaker activity against gt3a (1.212 nM), and maintaining high inhibitory activity against drug-resistant mutant strains such as gt1b R155K (IC₅₀ = 0.032 nM) and D168Y (IC₅₀ = 0.057 nM). MK-2748 can be used in the research of HCV infection ^[1].

HY-12731

GSK2236805	HCV	Infection
GSK2236805 is a potent hepatitis C virus inhibitor with pEC₅₀ values of 10.4, 11.1 for HCV genotype 1a (gt1a) and gt1b, respectively ^[1].

HY-12730

RG7109	HCV DNA/RNA Synthesis	Infection
RG7109 is an inhibitor of HCV NS5B polymerase. RG7109 has EC₅₀ values of 1.1 nM and 1.0 nM for HCV GT-1a H77 and GT-1b Con1, respectively. RG7109 exhibits favorable pharmacokinetic properties and can be used in anti-HCV research ^[1].

HY-172428

Encofosbuvir	HCV	Infection
Encofosbuvir is the inhibitor for HCV NS5B polymerase that inhibits GT1b, GT2a and GT3a with EC₅₀ of 102.4, 82.51 and 46.91 nM. Encofosbuvir inhibits HCV replication and can be used for reseearchs of hepatitis C in mammals ^[1].

HY-12373

AV-4025 hydrochloride	HCV Protease Influenza Virus	Infection
AV-4025 hydrochloride (Compound 13a) is an orally active NS5A inhibitor. AV-4025 hydrochloride is active against the HCV replicon GT1b (EC₅₀ = 0.003 nM). AV-4025 hydrochloride can be used for research on hepatitis C infection ^[1].

HY-16750

Radalbuvir GS-9669	DNA/RNA Synthesis HCV	Infection
Radalbuvir (GS-9669) is a non-nucleoside inhibitor of nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp). Radalbuvir shows strong anti-HCV potency (GT1a intrinsic EC₅₀ = 2.9 nM, GT1b EC₅₀ = 6 nM) ^[1].

HY-146126

NS5A-IN-4	HCV Protease	Infection
NS5A-IN-4 (Compound 1.12) is an orally active pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with IC₅₀ values of 1.2, 2296, 4.6, 362, 10.3 and 693 pM against *gT1b, gT1a, gT2a, gT3a, gT4a* and gT5a ^[1]. NS5A-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101634R

ABT-072 (Standard)	HCV Reference Standards	Infection
ABT-072 (Standard) is the analytical standard of ABT-072 (HY-101634). This product is intended for research and analytical applications. ABT-072 is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM) ^[1] .

HY-101634AR

ABT-072 potassium trihydrate (Standard)	HCV Reference Standards	Infection
ABT-072 (potassium trihydrate) (Standard) is the analytical standard of ABT-072 (potassium trihydrate) (HY-101634A). This product is intended for research and analytical applications. ABT-072 (potassium trihydrate) is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM) ^[1] .

HY-115516

BI-1388	HCV HCV Protease Ras	Infection
BI-1388 is a macrocyclic acylsulfonamide-based HCV NS3-4A protease inhibitor. BI-1388 inhibits clinically relevant drug-resistant mutant strains (KRAS ^D168V gt 1b and KRAS ^R155K gt 1a) and exhibits high liver distribution. BI-1388 is applicable for the research of HCV infection ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P11094

Tet1-Cys peptide	TET Protein	Neurological Disease
Tet1-Cys peptide is a peptide with the sequence HLNILSTLWKYRC. Tet1 (HLNILSTLWKYR) (HY-P10998) can specifically bind to the neuronal ganglioside receptor *GT1b, possessing neuronal targeting capabilities. The Tet1-Cys* peptide sequence has an added Cys, which can be used for drug conjugation for research on drug delivery ^[1].

HY-P10998

Tet1 peptide	TET Protein	Neurological Disease
Tet1 peptide is a peptide that specifically binds to neurons. Tet1 peptide binds to *GT1B* ganglioside and trisialoganglioside clostridial toxin receptor on the surface of neuronal cells, and can be used in peptide conjugation and drug delivery research ^[1] .

Cat. No.	Product Name	Chemical Structure

HY-15602AS

Ledipasvir-d6 hydrochloride
Ledipasvir-d₆ hydrochloride is deuterated labeled Ledipasvir acetone (HY-15602A). Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC₅₀ values of 34 pM against GT1a and 4 pM against GT1b replicon.

HY-131905S

BMS-986144
BMS-986144 is a third-generation, pan-genotype (GT) NS3/4A protease inhibitor. BMS-986144 inhibits HCV replicon with EC₅₀s of 2.3, 0.7, 1.0, 12, 8.0, and 5.8 nM for GT-1a, GT-1b, GT-2a, GT-3a, 1a R155X, and 1b D168V, respectively. BMS-986144 has the potential for the research of HCV infection ^[1].

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