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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
GT1b
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "GT1b" in MCE Product Catalog:
31
31 Publications Verification
Synonyms: GS-5885 D-tartrate
Ledipasvir D-tartrate is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
31
31 Publications Verification
Synonyms: GS-5885 (acetone)
Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
29
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Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively [1] . Grazoprevir inhibits SARS-CoV-2 3CL pro activity .
29
29 Cited Publications
Synonyms: MK-5172 potassium salt
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Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively [1] . Grazoprevir potassium salt inhibits SARS-CoV-2 3CL pro activity .
29
29 Cited Publications
Synonyms: MK-5172 hydrate
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Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively [1] . Grazoprevir hydrate inhibits SARS-CoV-2 3CL pro activity .
Cat. No.: HY-131686
CAS No.: 59247-13-1
Research Areas:
Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Ganglioside GT1b (bovine) ammonium is a member of the ganglioside family. Ganglioside GT1b (bovine) ammonium acts as a protective signal against nerve injury-induced spinal synapse elimination. Ganglioside GT1b (bovine) ammonium induces HA synthesis and the phosphorylation of Akt/mTOR in orbital fibroblasts. Ganglioside GT1b (bovine) ammonium enhances porcine oocyte maturation and induce activation of EGFR and ERK1/2 signaling. Ganglioside GT1b (bovine) ammonium is a putative host cell receptor for the Merkel cell polyomavirus. Ganglioside GT1b (bovine) ammonium can be used for the researches of cancer, infection, immunology, endocrinology and neurological disease, such as Thyroid eye disease [1] .
Cat. No.: HY-P11094
CAS No.: 1048681-88-4
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Synonyms: PPI-668 hydrochloride
Ravidasvir hydrochloride (PPI-668 hydrochloride) is a pan-genotypic inhibitor for hepatitis C virus (HCV) NS5A protein. Ravidasvir hydrochloride inhibits the replication of HCV, with EC50 of 0.12, 0.01 and 1.14 nM, for HCV gt-1a, gt-1b, and gt-3a replicons, respectively. Ravidasvir hydrochloride exhibits good pharmacokinetic characters in rats [1].
Cat. No.: HY-P10998
CAS No.: 270919-17-0
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Cat. No.: HY-131686A
CAS No.: 59247-13-1
Research Areas:
Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Ganglioside GT1b (porcine) ammonium is a member of the ganglioside family. Ganglioside GT1b (porcine) ammonium acts as a protective signal against nerve injury-induced spinal synapse elimination. Ganglioside GT1b (porcine) ammonium induces HA synthesis and the phosphorylation of Akt/mTOR in orbital fibroblasts. Ganglioside GT1b (porcine) ammonium enhances porcine oocyte maturation and induces activation of EGFR and ERK1/2 signaling. Ganglioside GT1b (porcine) ammonium is a putative host cell receptor for the Merkel cell polyomavirus. Ganglioside GT1b (porcine) ammonium can be used for the researches of cancer, infection, immunology, endocrinology and neurological disease, such as Thyroid eye disease [1] .
ABT-072 (potassium trihydrate) is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM) [1] .
Cat. No.: HY-W714151
CAS No.: 71012-19-6
Synonyms: Gg4cer; Asialoganglioside gm1; Asialo gm1, Gangliotetraosylceramide; Asialo ganglioside gm1a [...]; Ganglio-n-tetraosylceramide; Asialo gm1 ganglioside; Asialoganglioside GT1b
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Ganglioside ga1 (Gg4cer; Asialoganglioside gm1; Asialo gm1, Gangliotetraosylceramide; Asialo ganglioside gm1a [...]; Ganglio-n-tetraosylceramide; Asialo gm1 ganglioside; Asialoganglioside gt1b) is an ester product.
Cat. No.: HY-15602D
CAS No.: 1502655-48-2
Synonyms: GS-5885 (diacetone)
Ledipasvir diacetone (GS-5885 diacetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
Cat. No.: HY-15602AS
Synonyms: GS-5885-d6 hydrochloride
Cat. No.: HY-175073
Research Areas:
Ganglioside GT1b bovine trisodium is a trisialic acid ganglioside. Ganglioside GT1b bovine trisodium binds to botulinum toxin type A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively. Ganglioside GT1b bovine trisodium acts as a TLR2 agonist, leading to microglial activation, increased expression of pro-inflammatory factors, and increased pain sensitivity in spinal microglia. Ganglioside GT1b bovine trisodium also reduces the production of IL-6, IL-10, IgG, IgM, and IgA in human peripheral blood mononuclear cells (PBMCs). Ganglioside GT1b bovine trisodium increases extracellular glutamate levels in neural cell models. Ganglioside GT1b bovine trisodium has potential applications in research on immune system diseases and nervous system diseases [1] .
Cat. No.: HY-111087
CAS No.: 929890-64-2
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AZD-7295 is a HCV NS5A protein inhibitor, with an EC50 of 7 nM for GT-1b replicon [1] .
Cat. No.: HY-179818
CAS No.: 2707481-39-6
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C18:0 GT1b (d18:1/18:0) (triammonium) is a glycosphingolipid.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
