1. Anti-infection
  2. HCV
  3. ABT-072

ABT-072 

Cat. No.: HY-101634 Purity: 99.86%
Handling Instructions

ABT-072 is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM).

For research use only. We do not sell to patients.

ABT-072 Chemical Structure

ABT-072 Chemical Structure

CAS No. : 1132936-00-5

Size Price Stock Quantity
1 mg USD 250 In-stock
Estimated Time of Arrival: December 31
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2800 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of ABT-072:

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Description

ABT-072 is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM)[1][2][3].

IC50 & Target

NS5B polymerase[1]

In Vitro

ABT-072 is a non-nucleoside NS5B polymerase inhibitor with nanomolar potency in vitro against genotype 1a and 1b hepatitis C virus polymerases[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ABT-072 (5 and/or 30 mg/kg; i.v. or p.o.) shows good PK properties[3].
ABT-072 (2.5 and/or 30 mg/kg; i.v. or p.o.) shows low plasma clearance and high oral bioavailability[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[3]
Dosage: 5 and/or 30 mg/kg (Pharmacokinetic Analysis)
Administration: I.v. or p.o.
Result: Showed good PK properties.
Animal Model: Dog[3]
Dosage: 2.5 or 30 mg/kg (Pharmacokinetic Analysis)
Administration: I.v. or p.o.
Result: Showed low plasma clearance and high oral bioavailability.
Clinical Trial
Molecular Weight

469.55

Formula

C24H27N3O5S

CAS No.
SMILES

CS(=O)(NC1=CC=C(/C=C/C2=CC(N(C(N3)=O)C=CC3=O)=CC(C(C)(C)C)=C2OC)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 80 mg/mL (170.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1297 mL 10.6485 mL 21.2970 mL
5 mM 0.4259 mL 2.1297 mL 4.2594 mL
10 mM 0.2130 mL 1.0648 mL 2.1297 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 4 mg/mL (8.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 4 mg/mL (8.52 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 4 mg/mL (8.52 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.86%

References
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Product Name:
ABT-072
Cat. No.:
HY-101634
Quantity:
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