2. Anti-infection
  3. HCV
  4. Ledipasvir (diacetone)

Ledipasvir (diacetone)  (Synonyms: GS-5885 diacetone)

Cat. No.: HY-15602D
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Ledipasvir diacetone (GS-5885 diacetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.

For research use only. We do not sell to patients.

Ledipasvir (diacetone) Chemical Structure

Ledipasvir (diacetone) Chemical Structure

CAS No. : 1502655-48-2

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Ledipasvir (diacetone) Related Antibodies

Top Publications Citing Use of Products

27 Publications Citing Use of MCE Ledipasvir (diacetone)

WB

    Ledipasvir (diacetone) purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2015 Jun;59(6):3482-92.  [Abstract]

    Assessment of HCV inhibition by DAAs from 3 classes using Western blot analysis. Jc1/Gluc2A virus-infected Huh-7.5.1 cells are treated with DMSO or the HCV inhibitors at concentrations of 100× EC50 (DCV, 3.2 nM; LDV, 3 μM; DNV, 0.32 μM; SOF, 20 μM). Cell lysates are harvested at 8 hpt (C and D) or at 24 hpt (A and B) and blotted for NS5A (A and C) or core (B and D). Data are normalized to GAPDH and quantified as relative fold change with respect to DMSO.

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    Description

    Ledipasvir diacetone (GS-5885 diacetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.

    In Vitro

    Ledipasvir diacetone is considered the active ingredient, which is converted to Ledipasvir spray-dried dispersion, an amorphous free base.

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ledipasvir (diacetone) Related Antibodies
    Clinical Trial
    Molecular Weight

    1005.16

    Formula

    C55H66F2N8O8
    CAS No.
    SMILES

    O=C(OC)N[C@H](C(N([C@H](C1=NC=C(C2=CC(C(F)(F)C3=C4C=CC(C5=CC=C6N=C([C@H]7N(C([C@@H](NC(OC)=O)C(C)C)=O)[C@]8([H])CC[C@@]7([H])C8)NC6=C5)=C3)=C4C=C2)N1)C9)CC%109CC%10)=O)C(C)C.CC(C)=O.CC(C)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
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    Ledipasvir (diacetone) Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ledipasvir (diacetone)1502655-48-2GS-5885 diacetoneHCVHepatitis C virusInhibitorinhibitorinhibit

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