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Results for "

HCN2

" in MedChemExpress (MCE) Product Catalog:

19

Inhibitors & Agonists

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-160505
    RO-275

    		HCN Channel Neurological Disease
    RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder [2].
    RO-275
  • HY-13422
    Zatebradine hydrochloride
    2 Publications Verification

    UL-FS-49; UL-FS-49CL

    		 HCN Channel Cardiovascular Disease
    Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 µM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively .
    Zatebradine hydrochloride
  • HY-13422A
    Zatebradine
    2 Publications Verification

    UL-FS-49 free base; UL-FS-49CL free base

    		 HCN Channel Cardiovascular Disease
    Zatebradine (UL-FS-49 (free base); UL-FS-49CL (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 value of 1.96 µM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively .
    Zatebradine
  • HY-RS25103
    Hcn2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Hcn2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hcn2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Hcn2 Rat Pre-designed siRNA Set A
    Hcn2 Rat Pre-designed siRNA Set A
  • HY-RS06047
    HCN2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    HCN2 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    HCN2 Human Pre-designed siRNA Set A
    HCN2 Human Pre-designed siRNA Set A
  • HY-RS18617
    Hcn2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Hcn2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hcn2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Hcn2 Mouse Pre-designed siRNA Set A
    Hcn2 Mouse Pre-designed siRNA Set A
  • HY-186059
    HCN2 modulator-4

    		Potassium Channel Neurological Disease
    HCN2 modulator-4 is a HCN2 ion channel inhibitor. HCN2 modulator-4 inhibits HCN2 ion channel activity. HCN2 modulator-4 can be used for the research of pain, inflammatory pain, neuropathic pain, tinnitus, central nervous system disorders, psychiatric disorders, mood disorders .
    HCN2 modulator-4
  • HY-186059A
    HCN2 modulator-5

    		Potassium Channel Neurological Disease
    HCN2 modulator-5 (S-configuration 39) is a HCN2 ion channel inhibitor. HCN2 modulator-5 inhibits HCN2 ion channel activity. HCN2 modulator-5 can be used for the research of pain, inflammatory pain, neuropathic pain, tinnitus, central nervous system disorders, psychiatric disorders, mood disorders .
    HCN2 modulator-5
  • HY-186060
    HCN2 modulator-6

    		HCN Channel Neurological Disease
    HCN2 modulator-6 is a HCN2 ion channel inhibitor has an IC50 of 7 nM. HCN2 modulator-6 inhibits HCN2 ion channel activity. HCN2 modulator-6 can be used for the research of pain, inflammatory pain, neuropathic pain, tinnitus, central nervous system disorders, psychiatric disorders, mood disorders .
    HCN2 modulator-6
  • HY-186061A
    HCN2 modulator-8

    		Potassium Channel Neurological Disease
    HCN2 modulator-8 is a pyrazolopyridine derivative and selective HCN2 inhibitor. HCN2 modulator-8 can be used for the research of pain, tinnitus, central nervous system disorders, psychiatric disorders, mood disorders .
    HCN2 modulator-8
  • HY-186061
    HCN2-IN-4

    		HCN Channel Neurological Disease
    HCN2-IN-4 is an orally active HCN2 ion channel inhibitor, with an IC50 of 3 nM. HCN2-IN-4 inhibits the activity of HCN2 ion channels. HCN2-IN-4 can be used in the research of pain, tinnitus and central nervous system diseases .
    HCN2-IN-4
  • HY-186056
    HCN2-IN-3

    		HCN Channel Neurological Disease
    HCN2-IN-3 is an orally active HCN2 inhibitor. HCN2-IN-3 inhibits the activity of HCN2 ion channels. HCN2-IN-3 is applicable to research related to pain, tinnitus, central nervous system diseases, mental illnesses and mood disorders .
    HCN2-IN-3
  • HY-186057
    HCN2-IN-5

    		HCN Channel
    HCN2-IN-5 is a HCN2 ion channel inhibitor with an IC50 of 9 nM. HCN2-IN-5 shows weak inhibitory activity for HCN4. HCN2-IN-5 can be used for the research of inflammatory disease and neurological disorders .
    HCN2-IN-5
  • HY-186058
    HCN2-IN-6

    		HCN Channel Neurological Disease Inflammation/Immunology
    HCN2-IN-6 is a HCN2 ion channel inhibitor with an IC50 of 7 nM. HCN2-IN-6 shows weak inhibitory activity for HCN4. HCN2-IN-6 can be used for the research of inflammatory disease and neurological disorders .
    HCN2-IN-6
  • HY-186066
    HCN2-IN-2

    		HCN Channel Neurological Disease
    HCN2-IN-2 (Compound 35), azaindazole derivative, is a selective HCN2 inhibitor with an IC50 of 145 nM. HCN2-IN-2 inhibits HCN2 channel activity blocks abnormal firing of peripheral nociceptive neurons. HCN2-IN-2 can be used for the research of pain .
    HCN2-IN-2
  • HY-186065
    HCN2-IN-1

    		HCN Channel Neurological Disease
    HCN2-IN-1 (compound 32) is a HCN2 inhibitor with the IC50 of 98 nM. HCN2-IN-1 can be used for the research of central nervous system (CNS) and psychiatric disorders .
    HCN2-IN-1
  • HY-13422R
    Zatebradine hydrochloride (Standard)

    UL-FS-49 (Standard); UL-FS-49CL (Standard)

    		 HCN Channel Reference Standards Cardiovascular Disease
    Zatebradine (hydrochloride) (Standard) is the analytical standard of Zatebradine (hydrochloride). This product is intended for research and analytical applications. Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 μM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 μM, 2.21 μM, 1.90 μM and 1.88 μM, respectively .
    Zatebradine hydrochloride (Standard)
  • HY-18940
    Cilobradine

    Cilo

    		 Endogenous Metabolite Cardiovascular Disease
    Cilobradine (Cilo) is a HCN channel blocker with heart rate reducing activity. Cilobradine blocks the slow inward current of human HCN1, HCN2, HCN3, and HCN4 channels. Cilobradine has a slightly higher efficiency in blocking endogenous If in mouse sinoatrial node cells (IC50 value is 0.62μM). Cilobradine can dose-dependently reduce the heart rate from 600 to 200 bpm with an ED50 value of 1.2 mg/kg. Cilobradine induces arrhythmias at doses greater than 5 mg/kg, which are characterized by periodic fluctuations between T waves and P waves .
    Cilobradine
  • HY-186062
    HCN-IN-1

    		Toll-like Receptor (TLR) Potassium Channel Phosphatase Cardiovascular Disease Neurological Disease Inflammation/Immunology
    HCN-IN-1 is a TLR4 inhibitor and HCN channel modulator with activity against HCN2 and HCN4.HCN-IN-1 inhibits TLR4-mediated alkaline phosphatase (SEAP) signal activity.HCN-IN-1 reduces HCN2 current across tested voltages, shifts voltage-dependent activation to more hyperpolarized potentials, slows activation kinetics, and does not affect deactivation process.HCN-IN-1 blocks HCN4 current.HCN-IN-1 exhibits analgesic, anti-inflammatory, and anti-anginal effects.HCN-IN-1 can be used for the research of inflammatory pain, neuropathic pain, heart failure, inflammation .
    HCN-IN-1

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