91940-87-3
Chemical Structure
Zatebradine hydrochloride
Synonym(s): UL-FS-49; UL-FS-49CL
- CAS No.: 91940-87-3
- Formula:C26H37ClN2O5
- Molecular Weight:493.04
IUPAC Name: 3-(3-((3,4-dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride
InChIKey: ZRNKXJHEQKMWCH-UHFFFAOYSA-N
SMILES: O=C1N(CCCN(CCC2=CC=C(OC)C(OC)=C2)C)CCC3=CC(OC)=C(OC)C=C3C1.Cl
Biological Activity: Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 µM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively[1].
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Zatebradine hydrochloride | 99.87% | Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 µM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively. | ||||||||||||||||||||
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Zatebradine hydrochloride (Standard) | ≥98% | Zatebradine (hydrochloride) (Standard) is the analytical standard of Zatebradine (hydrochloride). This product is intended for research and analytical applications. Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 μM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 μM, 2.21 μM, 1.90 μM and 1.88 μM, respectively. | ||||||||||||||||||||
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Similarity Score 0.99
HY-13422AZatebradine -
Similarity Score 0.77
HY-18940ACilobradine hydrochloride -
Similarity Score 0.77
HY-18940Cilobradine -
Similarity Score 0.76
HY-B0162AIvabradine hydrochloride -
Similarity Score 0.76
HY-B0162Ivabradine -
Similarity Score 0.74
HY-106682Falipamil -
Similarity Score 0.72
HY-12778N-Demethyl Ivabradine hydrochloride -
Similarity Score 0.72
HY-B0162BIvabradine sulfate -
Similarity Score 0.71
HY-1312838-Demethyl Ivabradine -
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