1. Membrane Transporter/Ion Channel
  2. HCN Channel
  3. Cilobradine hydrochloride

Cilobradine hydrochloride (Synonyms: DK-AH 269)

Cat. No.: HY-18940A Purity: 98.33%
Handling Instructions

Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.

For research use only. We do not sell to patients.

Cilobradine hydrochloride Chemical Structure

Cilobradine hydrochloride Chemical Structure

CAS No. : 186097-54-1

Size Price Stock Quantity
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
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Description

Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels. Target: HCN Channel blocker Cilobradine is a HCN channel blocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, Cilobradine inhibits WT mHCN2 channel current by 86 ± 2% (n = 5). In contrast, I432A and A425G channel currents were only reduced by 14 ± 1% (n = 4) and 19 ± 2% (n = 8), respectively, by this concentration of Cilobradine. The double mutant (I432A/A425G) channel was even less sensitive to 10 μM Cilobradine (8 ± 2% inhibition; n = 4).

Clinical Trial
Molecular Weight

519.07

Formula

C28H39ClN2O5

CAS No.
SMILES

O=C1N(C[[email protected]@H]2CN(CCC3=CC=C(OC)C(OC)=C3)CCC2)CCC4=CC(OC)=C(OC)C=C4C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (192.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9265 mL 9.6326 mL 19.2652 mL
5 mM 0.3853 mL 1.9265 mL 3.8530 mL
10 mM 0.1927 mL 0.9633 mL 1.9265 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.33%

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Product Name:
Cilobradine hydrochloride
Cat. No.:
HY-18940A
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