186097-54-1
186097-54-1
Chemical Structure
Cilobradine hydrochloride
Synonym(s): DK-AH 269
- CAS No.: 186097-54-1
- Formula:C28H39ClN2O5
- Molecular Weight:519.07
IUPAC Name: (S)-3-((1-(3,4-dimethoxyphenethyl)piperidin-3-yl)methyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride
InChIKey: MTAKUIYCCYKGJJ-BOXHHOBZSA-N
SMILES: O=C1N(C[C@@H]2CN(CCC3=CC=C(OC)C(OC)=C3)CCC2)CCC4=CC(OC)=C(OC)C=C4C1.[H]Cl
Biological Activity: Cilobradine hydrochloride is a HCN channel blocker. Cilobradine hydrochloride induces cardiac pacemaker currents and produces antidepressant effects[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cilobradine hydrochloride | 99.73% | Cilobradine hydrochloride is a HCN channel blocker. Cilobradine hydrochloride induces cardiac pacemaker currents and produces antidepressant effects. | ||||||||||||||||||||
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References
- [1]. Cheng L, et al. Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels. J Pharmacol Exp Ther. 2007 Sep;322(3):931-939. [Content Brief]
- [2]. Van Bogaert PP, et al. Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71. [Content Brief]
- [3]. Stieber J, et al. Bradycardic and proarrhythmic properties of sinus node inhibitors. Mol Pharmacol. 2006 Apr;69(4):1328-37. [Content Brief]
- [4]. Umeya N, et al. Detection of retinal dysfunction induced by HCN channel inhibitors using multistep light stimulus and long-duration light stimulus ERG in rats. Exp Eye Res. 2024 Apr;241:109847. [Content Brief]
- [5]. Cai M, et al. HCN channel inhibitor induces ketamine-like rapid and sustained antidepressant effects in chronic social defeat stress model. Neurobiol Stress. 2023 Aug 19;26:100565. [Content Brief]
Keywords
