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Results for "

HS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) ADC Antibody (1) ADC Linker (3) ADC Payload (1) Akt (3) Antibody-Drug Conjugates (ADCs) (2) Apoptosis (13) Autophagy (4) Bacterial (2) Bcl-2 Family (1) Bcr-Abl (1) Biochemical Assay Reagents (6) c-Met/HGFR (5) Carbonic Anhydrase (1) Casein Kinase (3) Caspase (1) CD20 (1) CD276/B7-H3 (3) CDK (2) Cholinesterase (ChE) (1) CXCR (1) Cytochrome P450 (1) DAPK (4) Dengue Virus (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (1) Drug Derivative (2) Drug Intermediate (1) Drug Isomer (1) Drug-Linker Conjugates for ADC (3) EGFR (6) Endogenous Metabolite (1) Fatty Acid Synthase (FASN) (2) FBPase (1) Fluorescent Dye (4) Fungal (1) Glycoprotein VI (1) HBV (2) HCV (1) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (5) HIV (1) HSP (2) IKK (4) Interleukin Related (6) IRAK (6) Isotope-Labeled Compounds (1) Keap1-Nrf2 (4) LPL Receptor (9) mAChR (4) MDM-2/p53 (1) MEK (1) Melanocortin Receptor (4) Microtubule/Tubulin (2) MMP (2) MOFs (1) Monoamine Oxidase (1) mTOR (4) nAChR (1) Necroptosis (1) Notch (1) P-glycoprotein (1) p62 (4) PD-1/PD-L1 (1) Phosphodiesterase (PDE) (1) PI3K (2) Pim (1) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (1) PROTAC Linkers (27) PROTACs (4) Pyroptosis (4) Reactive Oxygen Species (ROS) (1) Reference Standards (4) RIP kinase (1) ROS Kinase (1) Serotonin Transporter (1) SGLT (1) Small Interfering RNA (siRNA) (13) SphK (1) STAT (1) TNF Receptor (3) Toll-like Receptor (TLR) (4) Topoisomerase (1) Transferrin Receptor (2) Trk Receptor (1)
By Research Areas:	Cancer (70) Cardiovascular Disease (5) Endocrinology (6) Infection (7) Inflammation/Immunology (26) Metabolic Disease (10) Neurological Disease (17)
Click Chemistry:	ADC Synthesis (1) PROTAC Synthesis (3) BCN (3) Azide (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Adjuvant (5) Human Pre-designed siRNA Sets (11) siRNAs (13)

147

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1893

Solutol HS-15 20+ Cited Publications Polyethylene glycol 12-hydroxystearate	Biochemical Assay Reagents	Others
Solutol HS-15, a Macrogol 15 hydroxy stearate, is a permeability enhancer .

HY-B0298A

Clemastine fumarate 10+ Cited Publications HS-592 fumarate; Meclastine fumarate	Histamine Receptor Apoptosis mAChR Pyroptosis Keap1-Nrf2 p62 Autophagy mTOR IKK	Neurological Disease Metabolic Disease
Clemastine (HS-592; Meclastine) fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .

HY-147141

HS-276 2 Publications Verification	IRAK TNF Receptor Casein Kinase Interleukin Related	Inflammation/Immunology
HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a K_i of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC₅₀ values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 reduces the expression of TNF, IL-6, and IL-1β. HS-276 can be used for rheumatoid arthritis (RA) research .

HY-112823

Almonertinib 5+ Cited Publications HS-10296	EGFR	Cancer
Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC₅₀: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer .

HY-B0298

Clemastine 10+ Cited Publications HS-592; Meclastine	Histamine Receptor mAChR Autophagy Apoptosis Keap1-Nrf2 p62 mTOR Pyroptosis IKK	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Clemastine (HS-592; Meclastine) is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .

HY-P991537

Risvutatug HS-20093 Antibody; GSK5764227 Antibody	ADC Antibody CD276/B7-H3	Cancer
HS-20093 Antibody (GSK5764227 Antibody) is an antibody targeting B7-H3, which can be used to synthesize the ADC HS-20093. HS-20093 Antibody exhibits anti-tumor activity. HS-20093 Antibody can be studied in research for small cell lung cancer, relapsed or refractory osteosarcoma, and advanced solid tumors .

HY-164146

BCN-HS-PEG2(vcPABC-MMAE)2 1 Publications Verification	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
BCN-HS-PEG2(vcPABC-MMAE)2 is a drug-linker conjugate for ADC consists an ADC linker and a tubulin polymerization inhibitor MMAE (HY-15162). BCN-HS-PEG2(vcPABC-MMAE)2 can be used in the synthesis of antibody-agent conjugates (ADCs) .

HY-130851

HS-27	HSP	Cancer
HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90. HS-27 has potential use in a see-and-treat paradigm in breast cancer .

HY-114349

HS-1371 4 Publications Verification	RIP kinase	Cardiovascular Disease Cancer
HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC₅₀ of 20.8 nM .

HY-15847

HS38 3 Publications Verification	DAPK	Cardiovascular Disease
HS38 is a potent, selective, and ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) and zipper-interacting protein kinase (ZIPK, also called DAPK3), with K_ds of 300 nM and 280 nM, respectively. HS38 is also a PIM3 inhibitor with an IC₅₀ of 200 nM. HS38 can be used for the research of smooth muscle related disorders .

HY-112823A

Almonertinib mesylate 5+ Cited Publications HS-10296 mesylate	EGFR	Cancer
Almonertinib (HS-10296) mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC₅₀: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib mesylate is used for the research of the non-small cell lung cancer .

HY-112823B

Almonertinib hydrochloride 5+ Cited Publications HS-10296 hydrochloride	EGFR	Cancer
Almonertinib (HS-10296) hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib hydrochloride shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC₅₀: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib hydrochloride is used for the research of the non-small cell lung cancer .

HY-15868

HS-173 5+ Cited Publications	PI3K Apoptosis	Cancer
HS-173 is a novel PI3K inhibitor, that is used for cancer treatment.

HY-168941A

HS-PEG3500-COOH	Biochemical Assay Reagents	Others
HS-PEG-COOH (Mn 3500) is a bi-functional PEG derivative. HS-PEG-COOH (Mn 3500) is used to synthesize PEG hydrogels .

HY-137453

Tenofovir amibufenamide 1 Publications Verification HS-10234	HBV	Infection
Tenofovir amibufenamide (HS-10234), a Tenofovir prodrug, is an orally active antiviral agent. Tenofovir amibufenamide inhibits HBV, and can be used for chronic hepatitis B (CHB) study .

HY-P990841

Anti-pan-Glypican Antibody (HS20)	Glycoprotein VI	Cancer
Anti-pan-Glypican Antibody (HS20) is a kind of human IgG1 κ human antibody, targeting to human pan-Glypican. Anti-pan-Glypican Antibody (HS20) can neutralize the heparan sulfate (HS) chains on GPC3 thereby disrupting the Wnt3a-GPC3 interactions leading to blockade of the Wnt3a/β-catenin signaling. Anti-pan-Glypican Antibody (HS20) can be used for the research of cancer, such as hepatocellular carcinoma (HCC) .

HY-P991703

Mocertatug GSK5733584 antibody; HS-20089 antibody; hu2F7	CD276/B7-H3	Cancer
Mocertatug (GSK5733584 antibody) is a humanized IgG1κ antibody targeting B7-H4/VTCN1. Mocertatug can be used to construct ADCs, such as Mocertatug Rezetecan (HY-185280) .

HY-117364

HS148	DAPK	Others
HS148 (compound 22) is a selective DAPK3 inhibitor with an K_i value of 119 nM .

HY-P1215A

HS024 TFA 1 Publications Verification	Melanocortin Receptor	Metabolic Disease
HS024 is a selective MC4 receptor antagonist, with K_is of 0.29, 3.29, 5.45, 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake .

HY-168937

HS-PEG2000-NH2 hydrochloride	PROTAC Linkers	Others
HS-PEG2000-NH2 hydrochloride is a bifunctional cross-linker that can be used to synthesize PEG hydrogels .

HY-130871

HS-PEG3-CH2CH2NH2 Thiol-PEG3-amine	PROTAC Linkers	Cancer
HS-PEG3-CH2CH2NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-133292

Thiol-PEG4-alcohol HS-PEG4-OH	PROTAC Linkers	Cancer
Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-134911

HS-243	IRAK CDK	Inflammation/Immunology Cancer
HS-243 is a potent and selective IRAK-4 and IRAK-1 inhibitor, with IC₅₀ values of 20 and 24 nM. HS-243 shows minimal TAK1 (transforming growth factor β-activated kinase 1) inhibition activity, with a IC₅₀ of 0.5 μM. HS-243 shows anti-inflammatory and anticancer activity .

HY-120040

HS94	DAPK	Cardiovascular Disease
HS94 is a selective DAPK3 inhibitor. HS94 can be used for research of hypertension .

HY-123983

HS56	Pim DAPK	Cardiovascular Disease
HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with K_i values of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension .

HY-145485

HS-PEG3400-SH	PROTAC Linkers	Others
HS-PEG3400-SH, a linear homobifunctional PEG, is a cross-linker. HS-PEG-SH can be used for drug delivery and preparation of PEG hydrogels .

HY-129156

HS-1793	Apoptosis	Cancer
HS-1793 is a Resveratrol (HY-16561) analogue with antitumor activities in a variety of cancer cell lines . HS-1793 induces cell apoptosis .

HY-131903

HS271	IRAK	Inflammation/Immunology
HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC₅₀ of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties .

HY-P1215

HS024	Melanocortin Receptor	Metabolic Disease
HS024 is a selective MC4 receptor antagonist, with K_is of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake .

HY-P99501

Zuberitamab HS006	CD20	Cancer
Zuberitamab (HS006) is a monoclonal antibody that targets CD20 and can be used in cancer research, including diffuse large B-cell lymphoma .

HY-176807

DBCO-HS-PEG2-VA-PABC-SG3199	Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker	Cancer
DBCO-HS-PEG2-VA-PABC-SG3199 is a drug-linker conjugate for ADC. DBCO-HS-PEG2-VA-PABC-SG3199 consists of a SG3199 (HY-101161) based DNA small channel crosslinker and cleavable linker. DBCO-HS-PEG2-VA-PABC-SG3199 can be used for synthesis of ADCs .

HY-130872A

HS-PEG5-CH2CH2NH2 hydrochloride Thiol-PEG5-amine hydrochloride	PROTAC Linkers	Cancer
HS-PEG5-CH2CH2NH2 hydrochloride is a PROTAC linker and belongs to the PEG class. Can be used to synthesize PROTAC molecules.

HY-130871A

HS-PEG3-CH2CH2NH2 hydrochloride Thiol-PEG3-amine hydrochloride	PROTAC Linkers	Cancer
HS-PEG3-CH2CH2NH2 hydrochloride (Thiol-PEG3-amine hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-133294

Thiol-PEG8-alcohol HS-PEG8-OH	PROTAC Linkers	Cancer
Thiol-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-130580

Thiol-PEG6-alcohol HS-PEG6-OH	PROTAC Linkers	Cancer
Thiol-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-157084

HS-291	ROS Kinase Bacterial	Infection
HS-291 is a HtpG inhibitor of Borrelia burgdorferi (Bb). HS-291 contains BX-2819 (high affinity for Bb HtpG), PEG linker, and Verteporfin (HY-B0146) (a photoactive toxin).HS-291 produces reactive oxygen species under light activation to oxidize HtpG and a discrete protein subset near chaperone proteins and can quickly and irreversibly inactivate Bb .

HY-122878

HS-131	HSP	Cancer
HS-131, a near infrared dye tethered Hsp90 inhibitor, is able to detect oncogene-driven breast cancers, including multiple different molecular subtypes of human breast cancers .

HY-P1216

HS014	Melanocortin Receptor	Neurological Disease
HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with K_is of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats .

HY-168941

HS-PEG7500-COOH	Biochemical Assay Reagents	Others
HS-PEG-COOH (Mn 7500) is a bi-functional PEG derivative. HS-PEG-COOH (Mn 7500) is used to synthesize PEG hydrogels .

HY-168937D

HS-PEG3500-NH2 hydrochloride	PROTAC Linkers	Others
HS-PEG-NH2 (Mn 3500) hydrochloride is a bifunctional cross-linker that can be used to synthesize PEG hydrogels .

HY-158199

BCN-HS-PEG2-bis(PNP)	ADC Linker	Cancer
BCN-HS-PEG2-bis(PNP) (Compound 62) is a p-nitrophenyl-containing ADC linker that can be used to further couple ADC cytotoxins with peptide linkers. BCN-HS-PEG2-bis(PNP) can conjugate with vc-PABC-MMAE (HY-15162) to form Drug-Linker Conjugates for ADC .

HY-159746

Carbomer adjuvant (HS801)	Biochemical Assay Reagents	Inflammation/Immunology
Carbomer adjuvant (HS801) is an adjuvant composed of carbomer and cationic polymers. This adjuvant is safe, non-toxic, and metabolizable. It can enhance the immune response, increase the antibody titer of each antigen component of the vaccine after immunization, and reduce the number of immunizations required. It is suitable for various veterinary vaccines. It is recommended for use in porcine circovirus, mycoplasma hyopneumoniae, and haemophilus parasuis.

HY-P1216A

HS014 TFA 1 Publications Verification	Melanocortin Receptor	Neurological Disease
HS014 TFA is a potent and selective melanocortin-4 (MC4) receptor antagonist, with K_is of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors respectively. HS014 TFA increases food intake in free-feeding rats .

HY-P991277

QX-004N HS-20137	Interleukin Related	Inflammation/Immunology
QX-004N (HS-20137) is a monoclonal antibody inhibitor targeting the p19 subunit of interleukin-23 (IL-23). QX-004N is promising for research of immune system diseases and diseases of digestive system .

HY-137453B

(1R)-Tenofovir amibufenamide (1R)-HS-10234	HBV HIV	Infection
(1R)-Tenofovir amibufenamide ((1R)-HS-10234) is the isomer of Tenofovir amibufenamide, is an orally active antiviral agent. (1R)-Tenofovir amibufenamide ((1R)-HS-10234) is a HIV infection inhibitor and HBV infection inhibitor. (1R)-Tenofovir amibufenamide ((1R)-HS-10234) can be used for HIV infections, hepatitis B research .

HY-176760

BCN-HS-PEG2-VA-PABC	ADC Linker	Cancer
BCN-HS-PEG2-VA-PABC is a ADC linker that can be used in the synthesis of PL1601 (HY-47018) .

HY-P99963

Sudubrilimab HS636	PD-1/PD-L1	Cancer
Sudubrilimab (HS636) is an Ig G1-kappa monoclonal antibody against PDL1. Sudubrilimab is fused at the C terminus of the heavy chain to a TGF-β1 receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment .

HY-130880

HS-PEG11-CH2CH2N3	PROTAC Linkers	Cancer
HS-PEG11-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . HS-PEG11-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130879

HS-PEG5-CH2CH2N3	PROTAC Linkers	Cancer
HS-PEG5-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . HS-PEG5-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-107176A

Hyzetimibe HS-25	Others	Metabolic Disease
Hyzetimibe is a cholesterol absorption inhibitor. Hyzetimibe blocks the intestinal absorption of cholesterol and phytol. Hyzetimibe is well tolerated in animal models, with an LD_max 2000 mg/kg in rats and an LD_max 500 mg/kg in rhesus monkeys .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-108826

Iduronate sulfatase Iduronate sulfate sulfatase	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Iduronate sulfatase (Iduronate sulfate sulfatase) is an exo-sulfatase that hydrolyzes the C2-sulfate ester bond from nonreducing terminal α-L-iduronic acid residues in HS .

HY-N15636

Coccinine (-)-Coccinine	Alkaloids Animals Haemanthus humilis Jacq. Other Alkaloids Plants Amaryllidaceae Source Classification	Serotonin Transporter P-glycoprotein
Coccinine ((-)-Coccinine) is a weak inhibitor of SERT (IC₅₀: 196.3 μM; K_i: 106.8 μM) and P-gp (IC₅₀: 0.96 mM). Coccinine exhibits significant anti-tumor activity against various cancer cell lines, such as breast cancer (MCF7, Hs578T, MDA-MB-231), colon cancer (HCT-15), and lung cancer (A549). Coccinine can be used in the research of tumors and neurological diseases .

Cat. No.	Product Name	Chemical Structure

HY-B0298AS

Clemastine-d5 fumarate

1 Publications Verification

Clemastine (HS-592; Meclastine)-d₅ fumarate is the deuterium labeled Clemastine fumarate. Clemastine fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .

HY-159176

Antitumor agent-183
Antitumor agent-183 (compound 3f) has antitumor activity with metabolic stability. Antitumor agent-183 inhibits cancer cell growth, with IC₅₀s less than 5 nM for A549, HCT116, and HS578T cells. The albumin-bound nanoparticle formulation of Antitumor agent-183 has prolonged retention in the tumor tissues .

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