BCN-HS-PEG2(vcPABC-MMAE)2
Based on 1 publication(s) in Google Scholar
BCN-HS-PEG2(vcPABC-MMAE)2 is a drug-linker conjugate for ADC consists an ADC linker and a tubulin polymerization inhibitor MMAE (HY-15162). BCN-HS-PEG2(vcPABC-MMAE)2 can be used in the synthesis of antibody-agent conjugates (ADCs).
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- Reinheit: 99.88%
- CAS. Nr.: 2126083-82-5
- Formel: C138H217N23O35S
- Molecular Weight:2790.40
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Speicherung:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) BCN-HS-PEG2(vcPABC-MMAE)2
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Biologische Aktivität
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Dual payloads |
Antibody-drug conjugates (ADCs) carry a highly potent small-molecule toxin covalently connected on the antibody via a proper linker. For therapeutic ADCs in cancer treatment, the antibody targets specific antigen of tumor cell surface with high binding affinity, thereafter the intact ADC was internalized into the tumor cells with the antigen and digested in the lysosome to release the antitumor toxin.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2126083-82-5
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Appearance Solid
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Molecular Weight 2790.40
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Formel C138H217N23O35S
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Color White to off-white
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SMILES
O=C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(OCCN(C(OCCOCCNS(=O)(NC(OC[C@@H]2[C@]3([H])CCC#CCC[C@@]32[H])=O)=O)=O)CCOC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C4)=CC=C4COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N5CCC[C@]([H])5[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C6=CC=CC=C6)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C1)=O)C)C(C)C)=O)C(C)C)=O)C)[C@H](CC)C)OC)N7[C@]([H])([C@@H]([C@H](C(N[C@@H]([C@@H](O)C8=CC=CC=C8)C)=O)C)OC)CCC7
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Chem Biol
Receptor-ubiquitination-targeting antibody-drug conjugates for enhanced endocytosis and lysosomal delivery. [Abstract]2026 Apr 16;33(4):506-522.e6. PMID: 41887220
Lösungsmittel & Löslichkeit
DMSO : ≥ 100 mg/mL (35.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.3584 mL | 1.7919 mL | 3.5837 mL | 8.9593 mL |
| 5 mM | 0.0717 mL | 0.3584 mL | 0.7167 mL | 1.7919 mL | |
| 10 mM | 0.0358 mL | 0.1792 mL | 0.3584 mL | 0.8959 mL | |
| 15 mM | 0.0239 mL | 0.1195 mL | 0.2389 mL | 0.5973 mL | |
| 20 mM | 0.0179 mL | 0.0896 mL | 0.1792 mL | 0.4480 mL | |
| 25 mM | 0.0143 mL | 0.0717 mL | 0.1433 mL | 0.3584 mL | |
| 30 mM | 0.0119 mL | 0.0597 mL | 0.1195 mL | 0.2986 mL |
BCN-HS-PEG2(vcPABC-MMAE)2 Related Classifications
HY-164146 Related Classifications
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