2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Microtubule/Tubulin
  4. BCN-HS-PEG2(vcPABC-MMAE)2

BCN-HS-PEG2(vcPABC-MMAE)2 is a drug-linker conjugate for ADC consists an ADC linker and a tubulin polymerization inhibitor MMAE (HY-15162). BCN-HS-PEG2(vcPABC-MMAE)2 can be used in the synthesis of antibody-agent conjugates (ADCs).

For research use only. We do not sell to patients.

BCN-HS-PEG2(vcPABC-MMAE)2

BCN-HS-PEG2(vcPABC-MMAE)2 Chemical Structure

CAS No. : 2126083-82-5

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Based on 1 publication(s) in Google Scholar

BCN-HS-PEG2(vcPABC-MMAE)2 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE BCN-HS-PEG2(vcPABC-MMAE)2

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms
Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

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  • Purity & Documentation

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  • Customer Review

Description

BCN-HS-PEG2(vcPABC-MMAE)2 is a drug-linker conjugate for ADC consists an ADC linker and a tubulin polymerization inhibitor MMAE (HY-15162). BCN-HS-PEG2(vcPABC-MMAE)2 can be used in the synthesis of antibody-agent conjugates (ADCs)[1].

IC50 & Target

Dual payloads

 

In Vitro

Antibody-drug conjugates (ADCs) carry a highly potent small-molecule toxin covalently connected on the antibody via a proper linker. For therapeutic ADCs in cancer treatment, the antibody targets specific antigen of tumor cell surface with high binding affinity, thereafter the intact ADC was internalized into the tumor cells with the antigen and digested in the lysosome to release the antitumor toxin.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BCN-HS-PEG2(vcPABC-MMAE)2 Related Antibodies
Molecular Weight

2790.40

Formula

C138H217N23O35S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(OCCN(C(OCCOCCNS(=O)(NC(OC[C@@H]2[C@]3([H])CCC#CCC[C@@]32[H])=O)=O)=O)CCOC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C4)=CC=C4COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N5CCC[C@]([H])5[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C6=CC=CC=C6)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C1)=O)C)C(C)C)=O)C(C)C)=O)C)[C@H](CC)C)OC)N7[C@]([H])([C@@H]([C@H](C(N[C@@H]([C@@H](O)C8=CC=CC=C8)C)=O)C)OC)CCC7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (35.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3584 mL 1.7919 mL 3.5837 mL
5 mM 0.0717 mL 0.3584 mL 0.7167 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.88%

SDS (252 KB)

COA (245 KB) HNMR (606 KB) RP-HPLC (226 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3584 mL 1.7919 mL 3.5837 mL 8.9593 mL
5 mM 0.0717 mL 0.3584 mL 0.7167 mL 1.7919 mL
10 mM 0.0358 mL 0.1792 mL 0.3584 mL 0.8959 mL
15 mM 0.0239 mL 0.1195 mL 0.2389 mL 0.5973 mL
20 mM 0.0179 mL 0.0896 mL 0.1792 mL 0.4480 mL
25 mM 0.0143 mL 0.0717 mL 0.1433 mL 0.3584 mL
30 mM 0.0119 mL 0.0597 mL 0.1195 mL 0.2986 mL
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BCN-HS-PEG2(vcPABC-MMAE)2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BCN-HS-PEG2(vcPABC-MMAE)22126083-82-5Drug-Linker Conjugates for ADCMicrotubule/TubulinADC linkerantibody-conjugateInhibitorinhibitorinhibit

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BCN-HS-PEG2(vcPABC-MMAE)2
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