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HS38 

Cat. No.: HY-15847
Handling Instructions

HS38 is a potent, selective, and ATP-competitive inhibitor of DAPK1 and ZIPK (DAPK3), with Kis of 300 nM and 280 nM, respectively. HS38 can be used for the research of smooth muscle related disorders.

For research use only. We do not sell to patients.

HS38 Chemical Structure

HS38 Chemical Structure

CAS No. : 1030203-81-6

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Description

HS38 is a potent, selective, and ATP-competitive inhibitor of DAPK1 and ZIPK (DAPK3), with Kis of 300 nM and 280 nM, respectively. HS38 can be used for the research of smooth muscle related disorders[1].

IC50 & Target

Kd: 300 nM (DAPK1), 280 nM (ZIPK)[1]

In Vitro

HS38 significantly reduces relative RLC20 phosphorylation in both the basal and sphingosine 1-phosphate (S1P) activated states in human aortic SM cells[1].
HS38 reduces contractile forces generated by intact mouse aorta in aortic tissue[1].
HS38 reduces the contractile force, RLC20 phosphorylation, and MYPT1 phosphorylation in Ca2+-sensitized rabbit ileum[1].

Western Blot Analysis[1]

Cell Line: CA-VSMCs
Concentration: 10 µM
Incubation Time: 40 minutes
Result: Reduced relative RLC20 phosphorylation in both the basal and S1P activated states.
Molecular Weight

349.80

Formula

C₁₄H₁₂ClN₅O₂S

CAS No.

1030203-81-6

SMILES

CC(SC1=NC(N(C2=CC=CC(Cl)=C2)N=C3)=C3C(N1)=O)C(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

HS38HS 38HS-38OthersDAPKdeathassociatedproteinkinasesmoothmusclezipper-interactingInhibitorinhibitorinhibit

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