1. Apoptosis
  2. DAPK
  3. HS38

HS38 

Cat. No.: HY-15847 Purity: ≥99.0%
Handling Instructions

HS38 is a potent, selective, and ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) and zipper-interacting protein kinase (ZIPK, also called DAPK3), with Kds of 300 nM and 280 nM, respectively. HS38 is also a PIM3 inhibitor with an IC50 of 200 nM. HS38 can be used for the research of smooth muscle related disorders.

For research use only. We do not sell to patients.

HS38 Chemical Structure

HS38 Chemical Structure

CAS No. : 1030203-81-6

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5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
25 mg USD 450 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

HS38 is a potent, selective, and ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) and zipper-interacting protein kinase (ZIPK, also called DAPK3), with Kds of 300 nM and 280 nM, respectively. HS38 is also a PIM3 inhibitor with an IC50 of 200 nM. HS38 can be used for the research of smooth muscle related disorders[1].

IC50 & Target

Kd: 300 nM (DAPK1), 79 nM (DAPK2), 280 nM (ZIPK), IC50: 200 nM (DAPK1), 200 nM (PIM3)[1]

In Vitro

HS38 displays high affinity toward DAPK2, with a Kd of 79 nM. DAPK2 is not implicated in smooth muscle contractility[1].
HS38 significantly reduces relative RLC20 phosphorylation in both the basal and sphingosine 1-phosphate (S1P) activated states in human aortic SM cells[1].
HS38 reduces contractile forces generated by intact mouse aorta in aortic tissue[1].
HS38 reduces the contractile force, RLC20 phosphorylation, and MYPT1 phosphorylation in Ca2+-sensitized rabbit ileum[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: CA-VSMCs
Concentration: 10 µM
Incubation Time: 40 minutes
Result: Reduced relative RLC20 phosphorylation in both the basal and S1P activated states.
Molecular Weight

349.80

Formula

C₁₄H₁₂ClN₅O₂S

CAS No.
SMILES

CC(SC1=NC(N(C2=CC=CC(Cl)=C2)N=C3)=C3C(N1)=O)C(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 7.14 mg/mL (20.41 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8588 mL 14.2939 mL 28.5878 mL
5 mM 0.5718 mL 2.8588 mL 5.7176 mL
10 mM 0.2859 mL 1.4294 mL 2.8588 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥99.0%

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Keywords:

HS38HS 38HS-38DAPKDeath associated protein kinasedeathassociatedproteinkinasesmoothmusclezipper-interactingInhibitorinhibitorinhibit

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