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Hydrastine (Standard)

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Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-B0927R
    Hydrastine (Standard)

    (-)-β-Hydrastine (Standard); (1R,9S)-β-Hydrastine (Standard)

    		 Reference Standards Tyrosine Hydroxylase Dopamine Receptor OAT Others
    Hydrastine (Standard) is the analytical standard of Hydrastine (HY-B0927). This product is intended for research and analytical applications. Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage .
    Hydrastine (Standard)

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