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Results for "

ITK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Itk (25) AAK1 (1) Apoptosis (1) BCRP (1) BMX Kinase (1) Btk (11) c-Kit (1) CDK (2) CXCR (2) EGFR (1) Ephrin Receptor (1) FAK (1) FGFR (1) FLT3 (1) IFNAR (1) Insulin Receptor (1) Interleukin Related (1) IRAK (1) JAK (1) LAG-3 (2) Ligands for Target Protein for PROTAC (1) MAP4K (1) MELK (1) NF-κB (1) p38 MAPK (2) PARP (1) PD-1/PD-L1 (2) PROTACs (6) Reference Standards (1) Small Interfering RNA (siRNA) (3) Trk Receptor (1) ULK (1) Wee1 (1)
By Research Areas:	Cancer (19) Inflammation/Immunology (18) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150298

Soquelitinib 3 Publications Verification CPI-818	Itk	Inflammation/Immunology Cancer
Soquelitinib (CPI-818) is an orally active and highly selective covalent interleukin-2-inducible kinase (ITK) inhibitor. Soquelitinib is active in six different models of T cell-mediated inflammatory and immune disease, including acute and chronic asthma, pulmonary fibrosis, systemic sclerosis (scleroderma), psoriasis, and acute graft versus host disease with Th2 cytokine product inhibition. Soquelitinib increases tumor infiltration of normal CD8 ⁺ cells that possess enhanced T effector function .

HY-11092

BMS-509744 5 Publications Verification	Itk	Inflammation/Immunology
BMS-509744 is a potent, selective and ATP competitive *Itk* inhibitor with an IC₅₀ of 19 nM.

HY-130665

TL12-186 1 Publications Verification	PROTACs CDK	Cancer
TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, *ITK, et al. TL12-186 inhibits CDK2/cyclin A* (IC₅₀=73 nM) and CDK9/cyclin T1 (IC₅₀=55 nM) .

HY-108691

PF-06465469 2 Publications Verification	Itk Btk CXCR PD-1/PD-L1 LAG-3	Cancer
PF-06465469 is a covalent inhibitor of *ITK* with an IC₅₀ of 2 nM. PF-06465469 also inhibits BTK. PF-06465469 inhibits cell migration in response to CXCL12. PF-06465469 decreases PD-1 and LAG-3 expression. PF-06465469 can be used to study leukemia and T-cell lymphoma .

HY-128726

ITK inhibitor 2 2 Publications Verification	Itk	Inflammation/Immunology
ITK inhibitor 2 is a *ITK* inhibitor with an IC₅₀ of 2 nM. ITK inhibitor 2 is used for research on inflammatory diseases, allergic diseases, autoimmune diseases and transplant rejection .

HY-12680

PRN694 3 Publications Verification	Itk	Inflammation/Immunology
PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor with IC₅₀s of 0.3 nM and 1.4 nM, respectively. PRN694 exhibits extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo .

HY-125218

*PARP11 inhibitor ITK7* ITK7	PARP	Cancer
PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor. PARP11 inhibitor ITK7 can potently inhibit PARP11 with an IC₅₀ value of 14 nM. PARP11 inhibitor ITK7 can be used for the research of cellular localization .

HY-148065

FMF-06-098-1	PROTACs Wee1 CDK AAK1 ULK MELK Itk IRAK Ephrin Receptor FGFR MAP4K p38 MAPK	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
FMF-06-098-1 is a multi-target kinase PROTAC degrader. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 .

HY-80002

BMX-IN-1 Maximum Cited Publications 7 Publications Verification BMX kinase inhibitor	Btk BMX Kinase	Cancer
BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys ⁴⁹⁶ in the BMX ATP binding domain with an IC₅₀ of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC₅₀ value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.

HY-174280

Modzatinib ITK kinase-IN-1	Itk JAK	Inflammation/Immunology
Modzatinib (ITK kinase-IN-1) is an oral active, selective, covalent *ITK/JAK3* dual-target inhibitor with IC₅₀ values of 8 nM and 23 nM, respectively. Modzatinib exhibits anti-inflammatory activity and can be used in the research of autoimmune and inflammatory diseases .

HY-109078

Vecabrutinib 2 Publications Verification SNS-062	Btk Itk	Cancer
Vecabrutinib (SNS-062) is a potent, noncovalent BTK and *ITK* inhibitor, with K_d values of 0.3 nM and 2.2 nM, respectively. Vecabrutinib shows an IC₅₀ of 24 nM for *ITK* .

HY-120559

GSK-2250665A	Itk	Inflammation/Immunology
GSK-2250665A (Compound 13) is a selective *Itk* inhibitor with a pK_i of 9.2.

HY-12410

GNE-9822	Itk	Inflammation/Immunology
GNE-9822 is a potent, orally active and selective *ITK* inhibitor with a K_i value of 0.7 nM, and an EC₅₀ value of 354.5 nM. GNE-9822 has good ADME properties. GNE-9822 can be used in research of asthma .

HY-174903

ITK-IN-6	Itk	Inflammation/Immunology
ITK-IN-6 is a highly potent and selective ITK inhibitor (K_d = 387 nM). ITK-IN-6 directly binds to the *ITK* kinase domain. ITK-IN-6 blocks the release of pro-inflammatory cytokines and the activation and differentiation of Th2 and Th17 cells. ITK-IN-6 improves asthma progression by reducing inflammatory cell infiltration, mucus and IgE production. ITK-IN-6 significantly inhibits airway inflammation and is used in asthma research .

HY-P5438

Srctide	Btk c-Kit FAK FLT3 Insulin Receptor	Others
Srctide is a biological active peptide. (This is a peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR).)

HY-149917

ITK degrader 1	PROTACs Itk	Cancer
ITK degrader 1 is a highly selective degrader of interleukin-2-inducible T-cell kinase (ITK; DC₅₀=3.6 nM in vivo in mice), with good plasma exposure levels. ITK degrader 1 induces rapid, and prolonged ITK degradation and suppresses IL-2 secretion (EC₅₀=35.2 nM, Jurkat cells) stimulated by anti-CD3 antibodyin vivo. ITK degrader 1 consists of target protein ligand (red part) ITK ligand 1 (HY-168387), PROTAC linker (black part) Piperidine-C2-piperazine-Boc (HY-168388) and E3 ubiquitinase ligand (blue part) Thalidomide 5-fluoride (HY-W087383). E3 ubiquitinase and PROTAC linker can form Thalidomide-piperidine-C2-piperazine-Boc (HY-168389) .

HY-153322

ITK degrader 2	PROTACs Itk	Inflammation/Immunology Cancer
ITK degrader 2 is an orally active ITK PROTAC degrader with a DC₅₀ < 0.001 nM. ITK degrader 2 degrades ITK via the ubiquitin-proteasome pathway. ITK degrader 2 can be used in the research of cancer, autoimmune diseases and inflammatory diseases .

HY-16984

GNE-4997	Itk	Inflammation/Immunology
GNE-4997 is a potent and selective interleukin-2-inducible T-cell kinase (ITK) inhibitor with a K_i of 0.09 nM, and the correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects reduces cytotoxicity .

HY-145373

BMS-986143	Btk	Inflammation/Immunology
BMS-986143 is an orally active, reversible BTK inhibitor with an IC₅₀ of 0.26 nM. BMS-986143 also inhibits TEC, BLK, BMX, TXK FGR, YES1, ITK with IC₅₀s of 3 nM, 5 nM, 7 nM, 10 nM, 15 nM,19 nM, 21 nM, respectively. BMS-986143 can be used for the research of autoimmune diseases .

HY-18010

PCI 29732 3 Publications Verification	Btk BCRP	Inflammation/Immunology
PCI 29732 is a potent, orally active, reversible BTK inhibitor with K_i ^app values of 8.2, 4.6, and 2.5 nM for BTK, Lck and Lyn, respectively. PCI 29732 shows only modest inhibitory activity against Itk, another Tec family kinase. PCI 29732 inhibits the function of ABCG2 by competitively binding to the ATP-binding site of ABCG2 .

HY-13232

ITK antagonist	Itk	Inflammation/Immunology
ITK antagonist (compound 10 n) is a potent, orally active and selective *ITK* (Interleukin-2 inducible T-cell kinase) antagonist (IC₅₀=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC₅₀ of 160 nM .

HY-146671

ITK inhibitor 5	Itk	Cancer
ITK inhibitor 5 (compound 27) is a potent and selective *ITK* inhibitor with IC₅₀s of 5.6, 25 nM for ITK, BTK, respectively .

HY-146672

ITK inhibitor 6	Itk	Cancer
ITK inhibitor 6 (compound 43) is a potent and selective *ITK* inhibitor with IC₅₀s of 4 nM, 133 nM, 320 nM, 2360 nM, 155 nM for ITK, BTK, JAK3, EGFR, LCK, respectively. ITK inhibitor 6 inhibits phosphorylation of PLCγ1 and ERK1/2. ITK inhibitor 6 shows antiproliferative activities .

HY-E70833

ITK Recombinant Human Active Protein Kinase	Itk	Cancer
ITK is the Tec family tyrosine kinase that has been implicated in T cell receptor (TCR) signaling. ITK Recombinant Human Active Protein Kinase is a recombinant ITK protein that can be used to study ITK-related functions .

HY-141864

ITK/TRKA-IN-1	Itk	Inflammation/Immunology
ITK/TRKA-IN-1 is a dual inhibitor of IL-2-inducible T-cell kinase (ITK) and tropomyosin receptor kinase A (TRKA) with an IC₅₀ value of 1.0 nM and 96 % inhibition, respectively.

HY-185206

BSJ-05-037	PROTACs Itk NF-κB	Cancer
BSJ-05-037 is an *ITK* PROTAC degrader that effectively targets and degrades ITK in T-cell lymphoma cell lines. BSJ-05-037 blocks the activation of the NF-κB/GATA-3 signaling pathway, inhibits PLCγ1 phosphorylation, and reduces the proliferative capacity of T-cell lymphoma cells. BSJ-05-037 enhances the sensitivity of T-cell lymphoma cells to chemotherapy. In mouse models of T-cell lymphoma, BSJ-05-037 induces ITK degradation, reduces GATA-3 expression, decreases tumor volume, and reverses chemotherapy resistance. BSJ-05-037 is applicable to research related to T-cell lymphoma .

HY-168963

PROTAC BTK Degrader-13	PROTACs Btk Itk p38 MAPK	Inflammation/Immunology Cancer
PROTAC BTK Degrader-13 (Compound 25) is the PROTAC degrader for BTK with a DC₅₀ of 0.27 μM. PROTAC BTK Degrader-13 inhibits the activity of BTK with an IC₅₀ of 0.44 μM, inhibits IL-2-induced T cell kinase (ITK) with an IC₅₀ of 2.16 μM. PROTAC BTK Degrader-13 inhibits p38 MAPK signaling pathway, block the activation of the BCR (B cell receptor) signaling pathway . (Pink: ligand for target protein BTK ligand 15 (HY-168965); Black: linker (HY-Y0524); Blue: ligand for E3 ligase cereblon (HY-103596))

HY-168387

ITK ligand 1	Ligands for Target Protein for PROTAC Itk	Cancer
ITK ligand 1 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). ITK ligand 1 can be used in the synthesis of PROTACs (e.g. HY-149917) .

HY-RS06979

ITK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ITK Human Pre-designed siRNA Set A contains three designed siRNAs for ITK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ITK Human Pre-designed siRNA Set A ITK Human Pre-designed siRNA Set A

HY-RS06981

Itk Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Itk Rat Pre-designed siRNA Set A contains three designed siRNAs for Itk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Itk Rat Pre-designed siRNA Set A Itk Rat Pre-designed siRNA Set A

HY-RS06980

Itk Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Itk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Itk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Itk Mouse Pre-designed siRNA Set A Itk Mouse Pre-designed siRNA Set A

HY-143900

BTK-IN-7	Btk Apoptosis	Inflammation/Immunology Cancer
BTK-IN-7 is a potent and selective inhibitor of BTK (IC₅₀=4.0 nM). BTK-IN-7 has high selectivity in both enzymatic (ITK >250-fold, EGFR >2500-fold) and cellular levels (ITK >227-fold, EGFR 27-fold). BTK-IN-7 also has potent antitumor activity .

HY-143901

EGFR-IN-40	Btk EGFR Itk	Cancer
EGFR-IN-40 (compound 3z) is a potent BTK, EGFR, and *ITK* inhibitor with IC₅₀ values of 1.2 nM, 5.3 nM, and 46.1 nM, respectively .

HY-110113

CTA056	Btk	Cancer
CTA056 is an *ITK* (IL-2-inducible T-cell kinase) inhibitor with an IC₅₀ of 0.1 μM. CTA056 selectively targets malignant T cells and modulates oncomirs. CTA056 induces apoptosis and is a potential therapeutic agent for the research of T-cell leukemia and lymphoma .

HY-182335

PF-07245303	Itk Trk Receptor Interleukin Related IFNAR	Inflammation/Immunology
PF-07245303 is a *ITK/TRK* inhibitor. PF-07245303 reduces the production of inflammatory cytokines such as IL-4 and IFNγ, and inhibits the phosphorylation of PLCγ1. PF-07245303 inhibits nerve growth factor-induced basophil activation and the phosphorylation of TRKA. PF-07245303 reduces oxazolone-induced ear swelling in mouse ear tissues. PF-07245303 is applicable to research related to atopic dermatitis .

HY-108691R

PF-06465469 (Standard)	Reference Standards Itk Btk CXCR PD-1/PD-L1 LAG-3	Cancer
PF-06465469 (Standard) is the analytical standard of PF-06465469 (HY-108691). This product is intended for research and analytical applications. PF-06465469 is a covalent inhibitor of ITK with an IC₅₀ of 2 nM. PF-06465469 also inhibits BTK. PF-06465469 inhibits cell migration in response to CXCL12. PF-06465469 decreases PD-1 and LAG-3 expression. PF-06465469 can be used to study leukemia and T-cell lymphoma .

Cat. No.	Product Name	Target	Research Area

HY-P5438

Srctide	Btk c-Kit FAK FLT3 Insulin Receptor	Others
Srctide is a biological active peptide. (This is a peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR).)

Species:	Human (1) Mouse (1)
Tag:	His (2) GST (2)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74795

	ITK Protein, Mouse (sf9, His-GST) Tyrosine-protein kinase ITK/TSK; IL-2-inducible T-cell kinase; ITK; EMT; LYK	Mouse	Sf9 insect cells
	ITK protein is a tyrosine kinase that plays a crucial role in directing adaptive immune responses by controlling the development, function, and differentiation of conventional T cells and unconventional NKT cells.After T cell receptor (TCR) activation by antigen-presenting cells (APC), ITK is recruited to the cell membrane and phosphorylated by LCK, thereby making it fully activated.ITK Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived ITK protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P705930

	ITK Protein, Human (Active, 269a.a, sf9, His, GST) ITK; IL2-inducible T-cell kinase; tyrosine-protein kinase ITK/TSK; EMT; LYK; PSCTK2; kinase EMT; T-cell-specific kinase; tyrosine-protein kinase LYK; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; homolog of mouse T-cell ITK/tsk; interleukin-2-inducible T cell kinase; interleukin-2-inducible T-cell kinase; MGC126257; MGC126258	Human	Sf9 insect cells
	ITK protein is an important tyrosine kinase that regulates adaptive immune responses by affecting the development and function of T cells and NKT cells. Upon T cell receptor (TCR) activation, ITK undergoes LCK-mediated phosphorylation, leading to its activation. ITK Protein, Human (Active, 269a.a, sf9, His, GST) is the recombinant human-derived ITK, expressed by Sf9 insect cells, with His and GST labeled tag.

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Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4)
Application:	IHC-P (2) ICC/IF (2) WB (4) FC (4) ELISA (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (4) Recombinant (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85135

	ITK Antibody (YA4827) ITK; EMT; LYK; Tyrosine-protein kinase ITK/TSK; Interleukin-2-inducible T-cell kinase; IL-2-inducible T-cell kinase; Kinase EMT; T-cell-specific kinase; Tyrosine-protein kinase Lyk	WB, ICC/IF, FC, ELISA	Human
	ITK Antibody (YA4827) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ITK.

HY-P85135A

	ITK Antibody (YA4827)(PBS only) ITK; EMT; LYK; Tyrosine-protein kinase ITK/TSK; Interleukin-2-inducible T-cell kinase; IL-2-inducible T-cell kinase; Kinase EMT; T-cell-specific kinase; Tyrosine-protein kinase Lyk	WB, ICC/IF, FC	Human
	ITK Antibody (YA4827) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ITK.

HY-P83601

	ITK Antibody (YA3346) ITK; EMT; LYK; Tyrosine-protein kinase ITK/TSK; Interleukin-2-inducible T-cell kinase; IL-2-inducible T-cell kinase; Kinase EMT; T-cell-specific kinase; Tyrosine-protein kinase Lyk	WB, IHC-P, FC	Human
	ITK Antibody (YA3346) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ITK.

HY-P83601A

	ITK Antibody (YA3346)(PBS only) ITK; EMT; LYK; Tyrosine-protein kinase ITK/TSK; Interleukin-2-inducible T-cell kinase; IL-2-inducible T-cell kinase; Kinase EMT; T-cell-specific kinase; Tyrosine-protein kinase Lyk	WB, IHC-P, FC	Human
	ITK Antibody (YA3346) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ITK.

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