Modzatinib
Based on 1 Customer Validation
Modzatinib (ITK kinase-IN-1) is an oral active, selective, covalent ITK/JAK3 dual-target inhibitor with IC50 values of 8 nM and 23 nM, respectively. Modzatinib exhibits anti-inflammatory activity and can be used in the research of autoimmune and inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 2411407-25-3
- Formula: C18H21F2N5O
- Molecular Weight:361.39
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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JAK3 |
Modzatinib (Compound I) (0.01-1000 ng/mL; 2-18 h) inhibits aCD3/CD28-induced IL2/IFNγ mRNA and IL15-induced pSTAT5 in whole blood[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Modzatinib (100-300 ppm; diet admixed; QD; 35 days) dose-dependently ameliorates inflammatory injury in the colon and ileum in a mouse T-cell transfer colitis model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice (male, ~20 g, 6-8 weeks); T cell transfer-induced inflammatory bowel disease[1]
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Dosage:100 ppm, 300 ppm
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Administration:diet admixed, QD, 35 days
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Result:Dose-dependently decreased histopathological scores in proximal colon, distal colon and ileum, and showed better protective effects than anti-IL12p40 antibody.
Chemical Information
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CAS No. 2411407-25-3
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Appearance Solid
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Molecular Weight 361.39
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Formula C18H21F2N5O
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Color White to off-white
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SMILES
FC(F)(C1)[C@H]1C2=CNC3=NC=NC(N[C@H]4CN([C@H](CC4)C)C(C=C)=O)=C23
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Synonyms
ITK kinase-IN-1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 6.25 mg/mL (17.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.7671 mL | 13.8355 mL | 27.6709 mL | 69.1773 mL |
| 5 mM | 0.5534 mL | 2.7671 mL | 5.5342 mL | 13.8355 mL | |
| 10 mM | 0.2767 mL | 1.3835 mL | 2.7671 mL | 6.9177 mL | |
| 15 mM | 0.1845 mL | 0.9224 mL | 1.8447 mL | 4.6118 mL |
Modzatinib Related Classifications
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