1 Result for "

IWR-1 (GMP)

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "IWR-1 (GMP)" in MCE Product Catalog:

Cat. No.: HY-12238G
CAS No.: 1127442-82-3
Synonyms: endo-IWR 1 (GMP); IWR-1-endo (GMP)
IWR-1 (IWR-1-endo) (GMP) is the IWR-1 (HY-12238) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/β-catenin (IC50 = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 promotes β-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis .
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