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Results for "

Iks

" in MedChemExpress (MCE) Product Catalog:

24

Inhibitors & Agonists

1

Peptides

3

Inhibitory Antibodies

1

Natural
Products

3

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-106369
    HMR 1556
    2 Publications Verification

    		 Potassium Channel Cardiovascular Disease
    HMR 1556, a chromanol derivative, is a potent IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively .
    HMR 1556
  • HY-108575
    Chromanol 293B
    1 Publications Verification

    		 Potassium Channel CFTR Cardiovascular Disease
    Chromanol 293B is a selective blocker of the slow delayed rectifier K + current (IKs) with IC50 of 1-10 μM and a weak inhibitor of KATP channel. Chromanol 293B also blocks the CFTR chloride current with an IC50 of 19 μM .
    Chromanol 293B
  • HY-16953
    JNJ 303
    1 Publications Verification

    		 Potassium Channel Cardiovascular Disease Neurological Disease
    JNJ-303 is a specific delayed rectifier Kv blocker. JNJ 303 can potent block IKs with an IC50 value of 64 nM. JNJ-303 can be used for the research of diabetes, obesity and central nervous system .
    JNJ 303
  • HY-108591
    L-364,373

    R-L3

    		 Potassium Channel Cardiovascular Disease
    L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes .
    L-364,373
  • HY-106577
    Cibenzoline

    Cifenline; Ro 22-7796

    		 Potassium Channel Cardiovascular Disease Metabolic Disease
    Cibenzoline is a class Ia antiarrhythmic active molecule with low anticholinergic activity. Cibenzoline is a KATP channel inhibitor, acting through the pore forming subunit Kir6.2, with an IC50 of 22.2 μM. Cibenzoline inhibits IKr and IKs currents with IC50 values of 8.8 μM and 12.3 μM, respectively. Cibenzoline is used in the study of cardiac diseases. In addition, Cibenzoline can induce hypoglycemia .
    Cibenzoline
  • HY-18600A
    Azimilide dihydrochloride
    2 Publications Verification

    NE-10064 dihydrochloride

    		 Potassium Channel Calcium Channel Sodium Channel Cardiovascular Disease
    Azimilide (NE-10064) dihydrochloride is a class III antiarrhythmic agent, which works by blocking potassium channels in the heart. Azimilide dihydrochloride is a dual blocker of IKs (IC50 = 2.6 μM (2mM [K⁺]ₑ)) and IKr (IC50 = 1 μM (4 mM [K⁺])). Azimilide dihydrochloride blocked HERG channel at 0.1 and 1 Hz with IC50s of 1.4 μM and 5.2 μM respectively. Azimilide dihydrochloride also inhibits L-type calcium current (ICa) (IC50 = 17.8 μM) and sodium current (INa) (IC50 = 19 μM). Azimilide dihydrochloride can be used for the study of atrial fibrillation and ventricular fibrillation .
    Azimilide dihydrochloride
  • HY-18600
    Azimilide
    2 Publications Verification

    NE-10064

    		 Potassium Channel Calcium Channel Sodium Channel Cardiovascular Disease
    Azimilide (NE-10064) is a class III antiarrhythmic agent, which works by blocking potassium channels in the heart. Azimilide is a dual blocker of IKs (IC50 = 2.6 μM (2mM [K⁺]ₑ)) and IKr (IC50 = 1 μM (4 mM [K⁺])). Azimilide blocked HERG channel at 0.1 and 1 Hz with IC50s of 1.4 μM and 5.2 μM respectively. Azimilide also inhibits L-type calcium current (ICa) (IC50 = 17.8 μM) and sodium current (INa) (IC50 = 19 μM). Azimilide can be used for the study of atrial fibrillation and ventricular fibrillation .
    Azimilide
  • HY-121977
    IKs124

    		Potassium Channel Inflammation/Immunology
    IKs124 is KCNE2/KCNQ1 potassium channel blocker with the with an IC50 of 8 nM. IKs124 can be used for study of peptic ulcers .
    IKs124
  • HY-120141
    L-768673

    		Potassium Channel Cardiovascular Disease
    L-768673 is a potent selective IKs blocker with antiarrhythmic effects. L-768673 plays important roles in both atrial and ventricular refractoriness as well as pacemaker function in the dog heart. L-768673 can be used for arrhythmias research .
    L-768673
  • HY-117174
    L-735821

    		Potassium Channel Cardiovascular Disease
    L-735821 is a Potassium channel blocker and an antagonist of IKs. L-735821 inhibits the KCNQ1 channel activity with an EC50 of 0.08 μM. L-735821 can increase IKs and IKr current-voltage relations in rabbit ventricular myocytes. L-735821 fully abolishes IKs in isolated human ventricular myocytes at 100 nmol/L. L-735821 can easily enter single myocytes .
    L-735821
  • HY-P990978
    Caxmotabart

    FS-1502 Antibody; Iks-014 Antibody

    		 EGFR Inflammation/Immunology
    HY-P990978 is an ERBB2-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
    Caxmotabart
  • HY-N15937
    IKS02

    		Biochemical Assay Reagents Others
    IKS02, a phosphatidylcholine (PC) phospholipid, is a photoaffinity labeling (PAL) probe .
    IKS02
  • HY-121520
    Docosahexaenoyl glycine

    		Potassium Channel Endogenous Metabolite Cardiovascular Disease
    Docosahexaenoyl glycine is a PUFA analogue. Docosahexaenoyl glycine has activating effects on IKs channels and restore the function of IKs channels with LQT1 mutation .
    Docosahexaenoyl glycine
  • HY-18600B
    (E)-Azimilide

    (E)-NE-10064

    		 Potassium Channel Cardiovascular Disease
    (E)-Azimilide is an isomer of Azimilide (HY-18600), a class of antiarrhythmic compounds that inhibit I(Ks) and I(Kr) activity .
    (E)-Azimilide
  • HY-110015
    (-)-Chromanol 293B

    		Potassium Channel Cardiovascular Disease
    (-)-Chromanol 293B is a potent and selective inhibitor of the slow component of delayed rectifier K + current (IKs). (-)-Chromanol 293B can be used for the research of antiarrhythmic .
    (-)-Chromanol 293B
  • HY-P992003
    IKS012 Antibody

    Iks01 Antibody

    		 ADC Antibody Cancer
    IKS012 Antibody (Isumab01) is a monoclonal antibody inhibitor targeting folate receptor α (FRA). IKS012 Antibody can be used to synthesize the antibody-drug conjugate (ADC) IKS012. IKS012 Antibody can be used to research related to platinum-resistant ovarian cancer .
    IKS012 Antibody
  • HY-106577R
    Cibenzoline (Standard)

    Cifenline (Standard); Ro 22-7796 (Standard)

    		 Reference Standards Potassium Channel Cardiovascular Disease Metabolic Disease
    Cibenzoline (Standard) is the analytical standard of Cibenzoline. This product is intended for research and analytical applications. Cibenzoline is a class Ia antiarrhythmic active molecule with low anticholinergic activity. Cibenzoline is a KATP channel inhibitor, acting through the pore forming subunit Kir6.2, with an IC50 of 22.2 μM. Cibenzoline inhibits IKr and IKs currents with IC50 values of 8.8 μM and 12.3 μM, respectively. Cibenzoline is used in the study of cardiac diseases. In addition, Cibenzoline can induce hypoglycemia .
    Cibenzoline (Standard)
  • HY-106577S
    Cibenzoline-d4

    Cifenline-d4; Ro 22-7796-d4

    		 Isotope-Labeled Compounds Potassium Channel Cardiovascular Disease Metabolic Disease
    Cibenzoline-d4 (Cifenline-d4) is deuterium labeled Cibenzoline. Cibenzoline is a class Ia antiarrhythmic active molecule with low anticholinergic activity. Cibenzoline is a KATP channel inhibitor, acting through the pore forming subunit Kir6.2, with an IC50 of 22.2 μM. Cibenzoline inhibits IKr and IKs currents with IC50 values of 8.8 μM and 12.3 μM, respectively. Cibenzoline is used in the study of cardiac diseases. In addition, Cibenzoline can induce hypoglycemia .
    Cibenzoline-d4
  • HY-P991899
    IKS03 Antibody

    LCB73 Antibody

    		 ADC Antibody CD19 Cancer
    IKS03 Antibody (LCB73 Antibody) is an anti-human CD19 antibody. IKS03 Antibody can generate antibody drug conjugate (ADC) (IKS03) with a pyrrolobenzodiazepine (PBD) dimer payload. IKS03 Antibody can be used for the study of diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) .
    IKS03 Antibody
  • HY-18600AS
    Azimilide-d8 dihydrochloride

    NE-10064-d8 dihydrochloride

    		 Isotope-Labeled Compounds Potassium Channel Calcium Channel Sodium Channel Cardiovascular Disease
    Azimilide-d8 (NE-10064-d8) dihydrochloride is the deuterium labeled Azimilide dihydrochloride (HY-18600A). Azimilide dihydrochloride is a class III antiarrhythmic agent, which works by blocking potassium channels in the heart. Azimilide dihydrochloride is a dual blocker of IKs (IC50 = 2.6 μM (2mM [K⁺]ₑ)) and IKr (IC50 = 1 μM (4 mM [K⁺])). Azimilide dihydrochloride blocked HERG channel at 0.1 and 1 Hz with IC50s of 1.4 μM and 5.2 μM respectively. Azimilide dihydrochloride also inhibits L-type calcium current (ICa) (IC50 = 17.8 μM) and sodium current (INa) (IC50 = 19 μM). Azimilide dihydrochloride can be used for the study of atrial fibrillation and ventricular fibrillation .
    Azimilide-d8 dihydrochloride
  • HY-108591R
    L-364,373 (Standard)

    R-L3 (Standard)

    		 Reference Standards Potassium Channel Cardiovascular Disease
    L-364,373 (Standard) is the analytical standard of L-364,373 (HY-108591). This product is intended for research and analytical applications. L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes .
    L-364,373 (Standard)
  • HY-182646
    NE-10133

    		Potassium Channel Cardiovascular Disease
    NE-10133 is a ISK and IKS potassium channel (Potassium Channel) inhibitor. NE-10133 inhibits voltage-dependent and slowly activated delayed rectifier potassium currents. NE-10133 exhibits class III antiarrhythmic activity. NE-10133 is applicable for research related to arrhythmias .
    NE-10133
  • HY-106369R
    HMR 1556 (Standard)

    		Reference Standards Potassium Channel Cardiovascular Disease
    HMR 1556 (Standard) is the analytical standard of HMR 1556 (HY-106369). This product is intended for research and analytical applications. HMR 1556, a chromanol derivative, is a potent IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively .
    HMR 1556 (Standard)
  • HY-106577S1
    Cibenzoline-d5

    Cifenline-d5; Ro 22-7796-d5

    		 Isotope-Labeled Compounds Cardiovascular Disease Metabolic Disease
    Cibenzoline-d5 (Cifenline-d5) is deuterium labeled Cibenzoline. Cibenzoline is a class Ia antiarrhythmic active molecule with low anticholinergic activity. Cibenzoline is a KATP channel inhibitor, acting through the pore forming subunit Kir6.2, with an IC50 of 22.2 μM. Cibenzoline inhibits IKr and IKs currents with IC50 values of 8.8 μM and 12.3 μM, respectively. Cibenzoline is used in the study of cardiac diseases. In addition, Cibenzoline can induce hypoglycemia .
    Cibenzoline-d5

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