1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. JNJ 303

JNJ 303 

Cat. No.: HY-16953 Purity: 99.18%
Handling Instructions

JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. JNJ 303 does not have any effects on other cardiac channels at concentrations of 3.3 μM for INa, Ica, Ito, and IKr. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP).

For research use only. We do not sell to patients.

JNJ 303 Chemical Structure

JNJ 303 Chemical Structure

CAS No. : 878489-28-2

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 107 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 420 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. JNJ 303 does not have any effects on other cardiac channels at concentrations of 3.3 μM for INa, Ica, Ito, and IKr. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP)[1].

IC50 & Target

IC50: 64 nM (IKs)[1]

Molecular Weight

440.98

Formula

C₂₁H₂₉ClN₂O₄S

CAS No.

878489-28-2

SMILES

ClC1=CC=C(OC(C)(C)C(N[[email protected]@H]([[email protected]@H](C2)C3)[[email protected]@H]4C[[email protected]]2C[[email protected]@]3(NS(=O)(C)=O)C4)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (141.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2677 mL 11.3384 mL 22.6768 mL
5 mM 0.4535 mL 2.2677 mL 4.5354 mL
10 mM 0.2268 mL 1.1338 mL 2.2677 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.18%

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Keywords:

JNJ 303JNJ303JNJ-303Potassium ChannelKcsAInhibitorinhibitorinhibit

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JNJ 303
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