1. JNJ 303

JNJ-303 is a specific delayed rectifier Kv blocker. JNJ 303 can potent block IKs with an IC50 value of 64 nM. JNJ-303 can be used for the research of diabetes, obesity and central nervous system.

For research use only. We do not sell to patients.

JNJ 303 Chemical Structure

JNJ 303 Chemical Structure

CAS No. : 878489-28-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 118 In-stock
Solution
10 mM * 1 mL in DMSO USD 118 In-stock
Solid
5 mg USD 121 In-stock
10 mg USD 198 In-stock
25 mg USD 462 In-stock
50 mg USD 825 In-stock
100 mg USD 1210 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE JNJ 303

  • Biological Activity

  • Purity & Documentation

  • Customer Review

Description

JNJ-303 is a specific delayed rectifier Kv blocker. JNJ 303 can potent block IKs with an IC50 value of 64 nM. JNJ-303 can be used for the research of diabetes, obesity and central nervous system[1][2].

IC50 & Target

IC50: 64 nM (IKs)[1]

In Vitro

JNJ 303 can block IKs with an IC50 value of 64 nM[1].
JNJ 303 (3.3 μM) does not have any effects on other cardiac channels[1].
JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

JNJ 303 recapitulates the Exn4-induced decrease in fasting blood glucose level in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

440.98

Formula

C21H29ClN2O4S

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

ClC1=CC=C(OC(C)(C)C(N[C@@H]([C@@H](C2)C3)[C@@H]4C[C@H]2C[C@@]3(NS(=O)(C)=O)C4)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (141.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2677 mL 11.3384 mL 22.6768 mL
5 mM 0.4535 mL 2.2677 mL 4.5354 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2677 mL 11.3384 mL 22.6768 mL 56.6919 mL
5 mM 0.4535 mL 2.2677 mL 4.5354 mL 11.3384 mL
10 mM 0.2268 mL 1.1338 mL 2.2677 mL 5.6692 mL
15 mM 0.1512 mL 0.7559 mL 1.5118 mL 3.7795 mL
20 mM 0.1134 mL 0.5669 mL 1.1338 mL 2.8346 mL
25 mM 0.0907 mL 0.4535 mL 0.9071 mL 2.2677 mL
30 mM 0.0756 mL 0.3779 mL 0.7559 mL 1.8897 mL
40 mM 0.0567 mL 0.2835 mL 0.5669 mL 1.4173 mL
50 mM 0.0454 mL 0.2268 mL 0.4535 mL 1.1338 mL
60 mM 0.0378 mL 0.1890 mL 0.3779 mL 0.9449 mL
80 mM 0.0283 mL 0.1417 mL 0.2835 mL 0.7086 mL
100 mM 0.0227 mL 0.1134 mL 0.2268 mL 0.5669 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
JNJ 303
Cat. No.:
HY-16953
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