878489-28-2
878489-28-2
Chemical Structure
JNJ 303
- CAS No.: 878489-28-2
- Formula:C21H29ClN2O4S
- Molecular Weight:440.98
IUPAC Name: 2-(4-chlorophenoxy)-2-methyl-N-((1R,2s,3S,5s,7s)-5-(methylsulfonamido)adamantan-2-yl)propanamide
InChIKey: OSGIRCJRKSAODN-HPMFMUNCSA-N
SMILES: ClC1=CC=C(OC(C)(C)C(N[C@@H]([C@@H](C2)C3)[C@@H]4C[C@H]2C[C@@]3(NS(=O)(C)=O)C4)=O)C=C1
Biological Activity: JNJ-303 is a specific delayed rectifier Kv blocker. JNJ 303 can potent block IKs with an IC50 value of 64 nM. JNJ-303 can be used for the research of diabetes, obesity and central nervous system[1][2].
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JNJ 303 | 99.70% | JNJ-303 is a specific delayed rectifier Kv blocker. JNJ 303 can potent block IKs with an IC50 value of 64 nM. JNJ-303 can be used for the research of diabetes, obesity and central nervous system. | ||||||||||||||||||||
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JNJ 303-d3 | JNJ 303-d3 is the deuterium labeled JNJ 303 (HY-16953). JNJ-303 is a specific delayed rectifier Kv blocker. JNJ 303 can potent block IKs with an IC50 value of 64 nM. JNJ-303 can be used for the research of diabetes, obesity and central nervous system. | |||||||||||||||||||||
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References
- [1]. Julie Albrecht, et al. The effect of the KV7/KCNE 1 inhibitor JNJ 303 on heart slices and the L-type calcium channel of cardiac cells.
- [2]. Zhaohuan Huang, et al. Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism. Sci Adv. 2022 Jun 10;8(23):eabn5345. [Content Brief]
Keywords
