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KG-FP-003

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-186117
    KG-FP-003

    		YAP PROTACs Cancer
    KG-FP-003 is a highly potent, selective, and durable TEAD PROTAC degrader (TEAD1 DC50 = 6 ± 4 nM, TEAD2 DC50 = 68 ± 15 nM, TEAD3 DC50 = 12 ± 5 nM, TEAD4 DC50 = 7 ± 5 nM). KG-FP-003 promotes ubiquitination and degradation of TEAD. KG-FP-003 exhibits anticancer activity against mesothelioma and ovarian cancer .
    KG-FP-003
  • HY-186118
    TEAD ligand 6

    		Ligands for Target Protein for PROTAC YAP Neurological Disease Cancer
    TEAD ligand 6 is a TEAD ligand. TEAD ligand 6 serves as a ligand for target protein for PROTAC (Ligands for Target Protein for PROTAC) and is used to develop and design PROTAC-based TEAD degraders, such as KG-FP-003 (HY-186117). TEAD ligand 6 applies to glioblastoma research .
    TEAD ligand 6
  • HY-186119
    E3 Ligase Ligand-linker Conjugate 228

    		E3 Ligase Ligand-Linker Conjugates Neurological Disease Cancer
    E3 Ligase Ligand-linker Conjugate 228 is an E3 ligase CRBN ligand-linker conjugate composed of 2-(4-(2,4-Dioxotetrahydropyrimidin-1 (2H)-yl)-3-methylphenoxy) acetic acid (HY-W733199) and a linker. E3 ligase ligand-linker conjugates can be used to synthesize degraders of PROTAC TEAD, such as KG-FP-003 (HY-186117). E3 Ligase Ligand-linker Conjugate 228 can be applied to glioblastoma research .
    E3 Ligase Ligand-linker Conjugate 228

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