3066008-42-9
Chemical Structure
KG-FP-003
- CAS No.: 3066008-42-9
- Formula:C58H67ClF2N6O8
- Molecular Weight:1049.64
InChIKey: AXGQADSJMZIYAN-SBUXFFIJSA-N
SMILES: CNC(C1=[C@](C(F)=C2C(C[C@@H]([C@@H]2O)C)=C1)[C@]3=C(C(F)=CC4=C3C[C@@](C5=CC=CC=C5)(O4)CNC6CCC(CC6)C(N7CCC(CC7)CC8CCN(CC8)C(COC9=CC=C(C(C)=C9)N%10CCC(NC%10=O)=O)=O)=O)Cl)=O
Biological Activity: KG-FP-003 is a highly potent, selective, and durable TEAD PROTAC degrader (TEAD1 DC50 = 6 ± 4 nM, TEAD2 DC50 = 68 ± 15 nM, TEAD3 DC50 = 12 ± 5 nM, TEAD4 DC50 = 7 ± 5 nM). KG-FP-003 promotes ubiquitination and degradation of TEAD. KG-FP-003 exhibits anticancer activity against mesothelioma and ovarian cancer[1].
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KG-FP-003 | KG-FP-003 is a highly potent, selective, and durable TEAD PROTAC degrader (TEAD1 DC50 = 6 ± 4 nM, TEAD2 DC50 = 68 ± 15 nM, TEAD3 DC50 = 12 ± 5 nM, TEAD4 DC50 = 7 ± 5 nM). KG-FP-003 promotes ubiquitination and degradation of TEAD. KG-FP-003 exhibits anticancer activity against mesothelioma and ovarian cancer. | |||||||||||||||||||||
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Keywords
