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Results for "

KHK

" in MedChemExpress (MCE) Product Catalog:

26

Inhibitors & Agonists

9

Inhibitory Antibodies

1

Recombinant Proteins

1

Isotope-Labeled Compounds

1

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99955
    Rocatinlimab

    AMG 451; KHK4083

    		 Orexin Receptor (OX Receptor) Infection Inflammation/Immunology
    Rocatinlimab (AMG 451) (KHK4083) is a fully human immunoglobulin G1 (IgG1) anti-OX40 monoclonal antibody. Rocatinlimab can be used for the research of atopic dermatitis (AD) .
    Rocatinlimab
  • HY-17613
    Evocalcet
    3 Publications Verification

    KHK7580

    		 CaSR Metabolic Disease
    Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .
    Evocalcet
  • HY-P9925
    Brodalumab
    4 Publications Verification

    AMG 827; KHK4827

    		 Interleukin Related Inflammation/Immunology
    Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis .
    Brodalumab
  • HY-P9923
    Benralizumab
    1 Publications Verification

    MEDI-563; BIW-8405; KHK4563

    		 Interleukin Related Apoptosis Inflammation/Immunology Cancer
    Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma .
    Benralizumab
  • HY-103478
    KHK-IN-2

    		Ketohexokinase Metabolic Disease
    KHK-IN-2 is a potent and selective ketohexokinase (KHK) inhibitor with an IC50 of 0.45 μM.
    KHK-IN-2
  • HY-12841A
    KHK-IN-1 hydrochloride
    1 Publications Verification

    		 Ketohexokinase Metabolic Disease
    KHK-IN-1 hydrochloride (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 hydrochloride inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 hydrochloride has potential for the study of diabetes and obesity .
    KHK-IN-1 hydrochloride
  • HY-149987
    LY3522348

    KHK-IN-3

    		 Ketohexokinase Cardiovascular Disease Metabolic Disease Inflammation/Immunology
    KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation .
    LY3522348
  • HY-U00461
    PF-06835919

    Ketohexokinase inhibitor 1

    		 Ketohexokinase Metabolic Disease
    PF-06835919 (Ketohexokinase inhibitor 1) is an inhibitor of ketohexokinase (KHK), with IC50s of 8.4 nM and 66 nM for KHK-C and KHK-A, respectively. PF-06835919 can be used for the study of metabolic disorders driven by the overconsumption of Fructose (HY-N0395) .
    PF-06835919
  • HY-12841
    KHK-IN-1
    1 Publications Verification

    		 Ketohexokinase Metabolic Disease
    KHK-IN-1 (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 has potential for the study of diabetes and obesity .
    KHK-IN-1
  • HY-17613R
    Evocalcet (Standard)

    KHK7580 (Standard)

    		 Reference Standards CaSR Metabolic Disease
    Evocalcet (Standard) is the analytical standard of Evocalcet. This product is intended for research and analytical applications. Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .
    Evocalcet (Standard)
  • HY-P991536
    KHK6640

    		Amyloid-β Neurological Disease
    KHK6640 is a humanized anti-amyloid beta oligomer-specific antibody. KHK6640 demonstrates high potency and efficacy for cognitive improvement in several rodent Alzheimer’s models. KHK6640 can be studied in research for neurological diseases such as Alzheimer’s disease .
    KHK6640
  • HY-159123
    KHK-6

    		MAP4K Cancer
    KHK-6 is an inhibitor for serine/threonine kinase hematopoietic progenitor kinase 1 (HPK 1) with an IC50 of 20 nM. KHK-6 enhances CD3/CD28-induced cytokine production, enhances CD69, CD25 and HLA-DR markers on CD4+ and CD8+ T cells, and enhances T cell-mediated killing activity of SKOV3 and A549 cells .
    KHK-6
  • HY-172610
    KHK-IN-7

    		Ketohexokinase Metabolic Disease
    KHK-IN-7 (compound 2) is a ketohexokinase (KHK) inhibitor. KHK-IN-7 can be used for study of metabolic disorders .
    KHK-IN-7
  • HY-149605
    KHK-IN-4

    		Ketohexokinase Metabolic Disease
    KHK-IN-4 (compound 14) is a potent ketohexokinase (KHK) inhibitor. KHK-IN-4 can be used for fructose metabolic disease research .
    KHK-IN-4
  • HY-162982
    KHK-IN-6

    		Ketohexokinase Cancer
    KHK-IN-6 (compund 33) is a KHK inhibitor with IC50 of 0.6 nM .
    KHK-IN-6
  • HY-163886
    KHK-IN-5

    		Ketohexokinase Metabolic Disease
    KHK-IN-5 (Compound 18) is a KHK inhibitor. KHK-IN-5 can be used for the research of nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and type 2 diabetes (T2DM) .
    KHK-IN-5
  • HY-P991282
    KHK2823

    		Interleukin Related Cancer
    KHK2823 is a humanized monoclonal anti-human CD123/IL3RA antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001). KHK2823 can be used in research related to leukemia .
    KHK2823
  • HY-RS17728
    Khk Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Khk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Khk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Khk Mouse Pre-designed siRNA Set A
    Khk Mouse Pre-designed siRNA Set A
  • HY-RS07240
    KHK Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    KHK Human Pre-designed siRNA Set A contains three designed siRNAs for KHK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    KHK Human Pre-designed siRNA Set A
    KHK Human Pre-designed siRNA Set A
  • HY-17613S
    Evocalcet-d4

    KHK7580-d4

    		 Isotope-Labeled Compounds CaSR Metabolic Disease
    Evocalcet-d4 (KHK7580-d4) is deuterium labeled Evocalcet. Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .
    Evocalcet-d4
  • HY-P990609
    KHK-2866

    		EGFR Inflammation/Immunology
    KHK-2866 is a recombinant humanized monoclonal antibody targeting heparin-binding epidermal growth factor-like growth factor (HB-EGF). The predicted molecular weight (MW) of KHK-2866 is 147.68 kDa. KHK-2866 can be used for tumor research .
    KHK-2866
  • HY-103478R
    KHK-IN-2 (Standard)

    		Ketohexokinase Reference Standards Metabolic Disease
    KHK-IN-2 (Standard) is the analytical standard of KHK-IN-2 (HY-103478). This product is intended for research and analytical applications. KHK-IN-2 is a potent and selective ketohexokinase (KHK) inhibitor with an IC50 of 0.45 μM.
    KHK-IN-2 (Standard)
  • HY-P991918
    KHK2840

    IgG2-AAS

    		 Transmembrane Glycoprotein Interleukin Related Inflammation/Immunology Cancer
    KHK2840 is a potent CD40 agonist with a Kd value of 0.485 nM for hCD40. KHK2840 delivers agonistic signals in tumor-bearing hCD40 transgenic mice and human peripheral blood B cells. KHK2840 upregulates CD80, CD86, CD95 and IL-12p70 expression. KHK2840 enhances antitumor efficacy of anti-PD-1 antibody and Paclitaxel (HY-B0015). KHK2840 can be used for the research of cancer, such as colon cancer and melanoma .
    KHK2840
  • HY-RS24193
    Khk Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Khk Rat Pre-designed siRNA Set A contains three designed siRNAs for Khk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Khk Rat Pre-designed siRNA Set A
    Khk Rat Pre-designed siRNA Set A
  • HY-P992004
    KHK2805

    RA15-7, HuRA15-7Acc

    		 Folate Receptor (FR) Cancer
    KHK2805 (RA15-7) is a humanized antibody against folate receptor α (FOLR1), with a Kd of 0.647 nM for human FOLR1. KHK2805 binds to a unique epitope of FOLR1 and mediates antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity against FOLR1-expressing cells. KHK2805 exhibits cytotoxicity against both ovarian cancer cells and Platinum (HY-W096169D)-resistant ovarian cancer cells. KHK2805 can be used for the research of tumors such as ovarian cancer .
    KHK2805
  • HY-180921
    GS-1291269

    		Ketohexokinase Metabolic Disease Endocrinology
    GS-1291269 is a potent and neutral ketohexokinase (KHK) inhibitor, with IC50s of 0.38 and 2.1 nM against KHK-C and KHK-A, respectively. GS-1291269 demonstrates liver and kidney fructose-1-phosphate (F1P) reduction in a fructose challenge model in rats. GS-1291269 can be used for kidney disease and metabolic-dysfunction-associated steatotic liver disease (MASLD) research .
    GS-1291269

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