1044511-01-4
1044511-01-4
Chemical Structure
Benralizumab (anti-IL5RA)
Synonym(s): MEDI-563 (anti-IL5RA); BIW-8405 (anti-IL5RA); KHK4563 (anti-IL5RA)
- CAS No.: 1044511-01-4
- Formula:N/A
- Molecular Weight:(146.08 kDa)
SMILES: [Benralizumab (anti-IL5RA)]
Biological Activity: Benralizumab (anti-IL5RA) (MEDI-563 (anti-IL5RA); BIW-8405 (anti-IL5RA)) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma study [1][2].
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Benralizumab (anti-IL5RA) | 99.60% | Benralizumab (anti-IL5RA) (MEDI-563 (anti-IL5RA); BIW-8405 (anti-IL5RA)) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma study . | ||||||||||||||||||||
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Benralizumab | 95% | Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma. | ||||||||||||||||||||
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Benralizumab (FUT8-KO) | Benralizumab (FUT8-KO) (MEDI-563 (FUT8-KO)) is an anti-IL-5Rα monoclonal antibody expressed in cells with the fucosyltransferase 8 gene (FUT8) knocked out. Benralizumab (FUT8-KO) can be used in research on severe eosinophilic asthma. | |||||||||||||||||||||
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References
- [1]. Menzies-Gow A, et al. Corticosteroid tapering with benralizumab treatment for eosinophilic asthma: PONENTE Trial. ERJ Open Res. 2019;5(3):00009-2019. Published 2019 Sep 25. [Content Brief]
- [2]. Kolbeck R, et al. MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol. 2010;125(6):1344-1353.e2. [Content Brief]
