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Results for "

LAD2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Bacterial (1) Calcium Channel (2) Environmental Pollutants (1) ERK (1) Fc Receptor (FcR) (1) Glycosidase (1) Interleukin Related (4) Leukotriene Receptor (2) LPL Receptor (2) Mas-related G-protein-coupled Receptor (MRGPR) (6) P-glycoprotein (2) RXFP Receptor (1) TNF Receptor (2)
By Research Areas:	Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (9)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19989

MK-571 Maximum Cited Publications 33 Publications Verification L-660711	P-glycoprotein LPL Receptor Leukotriene Receptor	Inflammation/Immunology
MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D₄ (LTD₄) receptor antagonist, with K_i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release ^[2] .

HY-19989A

MK-571 sodium Maximum Cited Publications 33 Publications Verification L-660711 sodium	P-glycoprotein LPL Receptor Leukotriene Receptor	Inflammation/Immunology
MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D₄ (LTD₄) receptor antagonist, with K_i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release ^[2] .

HY-B1158

Imidazolidinyl urea	Environmental Pollutants Mas-related G-protein-coupled Receptor (MRGPR) Interleukin Related Bacterial	Infection
Imidazolidinyl urea is a commonly used antibacterial preservative in cosmetics and pharmaceuticals that releases formaldehyde through decomposition. Imidazolidinyl urea can also be used in the preparation of multifunctional hydrogels for the care of infectious wounds. Imidazolidinyl urea has broad-spectrum antibacterial activity, which mainly inhibits the reproduction of gram-negative bacteria and gram-positive bacteria, and restricts the growth of yeast and mold to a certain extent. Imidazolidinyl urea can induce non-histaminergic allergy by *MRGPRX2* activation of mast cells ^[2] .

HY-118069

(R)-ZINC-3573 1 Publications Verification	Mas-related G-protein-coupled Receptor (MRGPR)	Infection
(R)-ZINC-3573 is a selective Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist with an EC₅₀ value of 740 nM. (R)-ZINC-3573 can be used as a MRGPRX2 probe for the research of pain and itch .

HY-168532

ST2-IN-1	Interleukin Related	Inflammation/Immunology
ST2-IN-1 is a *ST2* inhibitor. ST2-IN-1 blocks the binding interaction between *ST2* and IL-33, thereby attenuating the downstream *ST2*/IL-33 signaling pathway. ST2-IN-1 reduces IL-1β release from mast cells and alleviates *ST2* upregulation in cells. ST2-IN-1 can be used for research on inflammatory and immune-related diseases .

HY-172458

Z-3578 1 Publications Verification	Mas-related G-protein-coupled Receptor (MRGPR) TNF Receptor	Inflammation/Immunology
Z-3578 is an orally active small-molecule antagonist of *MrgX2* with potent antipseudoallergic activity, exhibiting a K_D value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppresses the release of β-hexosaminidase, significantly reduces the release of histamine and TNF-α, and decreases intracellular calcium flux. In a mouse pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation, and reduces serum histamine levels. Z-3578 can be used for the study of pseudoallergic reactions .

HY-158990

GE1111	Mas-related G-protein-coupled Receptor (MRGPR) Interleukin Related TNF Receptor Akt ERK	Inflammation/Immunology
GE1111 is a *MRGPRX2* antagonist (IC₅₀ = 9.4 μM). GE1111 inhibits *MRGPRX2/MRGPRB2*-mediated mast cell activation. GE1111 reduces the expressions of TSLP, IL-13, MCP-1, TNF-α, IL-1β and periostin, maintains the expression levels of claudin 1 and involucrin, restores the phagocytic activity of macrophages, and attenuates the activation of STIM1 and phosphorylated AKT. GE1111 exerts anti-inflammatory and anti-allergic effects in multiple animal models. GE1111 is applicable to the research related to rosacea, atopic dermatitis and ulcerative colitis ^[2] .

HY-145891

B10-S	Others	Inflammation/Immunology
B10-S is a potent anti-allergic agent. B10-S can inhibit the degranulation of LAD2 induced by substance P .

HY-174452

BER-5	Mas-related G-protein-coupled Receptor (MRGPR) Interleukin Related Calcium Channel	Inflammation/Immunology
BER-5 is a potent *MrgX2* antagonist. BER-5 possess broad-spectrum antagonistic activity against a diverse range of MrgX2 agonists. BER-5 can inhibit Substance P (SP) (HY-P0201)-induced degranulation of LAD2 cells. BER-5 attenuates SP-induced allergic reactions in mice. BER-5 can be used for the study of allergic reactions.

HY-P991651

MEDI4212	Fc Receptor (FcR)	Inflammation/Immunology
MEDI4212 is a humanized IgG1λ monoclonal antibody inhibitor targeting IgE. MEDI4212 potently inhibits human IgE-mediated functional responses through its receptor FcεRI, such as calcium signaling, β-hexosaminidase release and phagocytosis. MEDI4212 prevents the binding of IgE to CD23 with an IC₅₀ of 8 nM. MEDI4212 can be used severe asthma research .

HY-P11619

R2R01	RXFP Receptor	Cardiovascular Disease
R2R01 is a potent and selective relaxin family peptide receptor 1 (RXFP1) agonist with an EC₅₀ of 0.34 nM. R2R01 activates RXFP1 to induce relaxin-like biological responses. R2R01 can increase heart rate in pithed and conscious rats. R2R01 can be used for the research of cardiovascular diseases .

HY-181891

XAT-13	Mas-related G-protein-coupled Receptor (MRGPR) Calcium Channel Glycosidase	Inflammation/Immunology
XAT-13 is an orally active antiallergic agent. XAT-13 binds to the active pocket of *MRGPRX2, and inhibits C48/80-induced calcium influx* and β-hexosaminidase release. XAT-13 can be used for the research of pseudo-allergic diseases .

Cat. No.	Product Name	Target	Research Area

HY-P11619

R2R01	RXFP Receptor	Cardiovascular Disease
R2R01 is a potent and selective relaxin family peptide receptor 1 (RXFP1) agonist with an EC₅₀ of 0.34 nM. R2R01 activates RXFP1 to induce relaxin-like biological responses. R2R01 can increase heart rate in pithed and conscious rats. R2R01 can be used for the research of cardiovascular diseases .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991651

MEDI4212	Fc Receptor (FcR)	Inflammation/Immunology
MEDI4212 is a humanized IgG1λ monoclonal antibody inhibitor targeting IgE. MEDI4212 potently inhibits human IgE-mediated functional responses through its receptor FcεRI, such as calcium signaling, β-hexosaminidase release and phagocytosis. MEDI4212 prevents the binding of IgE to CD23 with an IC₅₀ of 8 nM. MEDI4212 can be used severe asthma research .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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