MrgprX2 antagonist-11
Based on 1 Customer Validation
MrgprX2 antagonist-11 is a potent MrgprX2 antagonist. MrgprX2 antagonist-11 inhibits MrgprX2-mediated accumulation and mast cell degranulation (IC50 < 100 nM), thereby blocking mast cell activation. MrgprX2 antagonist-11 can be used in research on MrgprX2-related inflammatory and allergic diseases.
For research use only. We do not sell to patients.
- Purity: 99.32%
- CAS No.: 3116847-13-0
- Formula: C26H28FN5O4
- Molecular Weight:493.53
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
MrgprX2 antagonist-11 (Example 53) (15 min pre-incubation + 60 min stimulation) shows inhibitory activity against IP1 accumulation in hMrgprX2-overexpressing HEK293 cells, with an activity grade of "+++" (IC50 < 100 nM)[1].
MrgprX2 antagonist-11 (15 min pre-incubation + 30 min stimulation) shows inhibitory activity against β-hexosamine release in LAD2 human mast cells, with an activity grade of "+++" (IC50 < 100 nM)[1].
The structure of MrgprX2 antagonist-11 is confirmed by 1H NMR and LCMS. The measured MS (ESI) m/z = 494.05 [M+H]+, which is consistent with the theoretical value[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3116847-13-0
-
Appearance Solid
-
Molecular Weight 493.53
-
Formula C26H28FN5O4
-
Color White to off-white
-
SMILES
O=C(C(C=C1)=CNC1=O)N2C(C)(CN(CC2)[C@@H](C)C(NC3=CC=C(C=N3)OC4=CC=C(C=C4)F)=O)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
-
Data Sheet (265 KB)
-
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)