2883669-12-1
Chemical Structure
GE1111
- CAS No.: 2883669-12-1
- Formula:C28H22N2O5
- Molecular Weight:466.48
InChIKey: IMTTVPWLOQWCDD-UHFFFAOYSA-N
SMILES: O=CC1=CC2=C3C(C1C)=C(O)C=CC3=CC(C4=CC5=C(C=C4C(OC)=O)C=C(NC(N)=O)C=C5)=C2
Biological Activity: GE1111 is a MRGPRX2 antagonist (IC50 = 9.4 μM). GE1111 inhibits MRGPRX2/MRGPRB2-mediated mast cell activation. GE1111 reduces the expressions of TSLP, IL-13, MCP-1, TNF-α, IL-1β and periostin, maintains the expression levels of claudin 1 and involucrin, restores the phagocytic activity of macrophages, and attenuates the activation of STIM1 and phosphorylated AKT. GE1111 exerts anti-inflammatory and anti-allergic effects in multiple animal models. GE1111 is applicable to the research related to rosacea, atopic dermatitis and ulcerative colitis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GE1111 | 95.73% | GE1111 is a MRGPRX2 antagonist (IC50 = 9.4 μM). GE1111 inhibits MRGPRX2/MRGPRB2-mediated mast cell activation. GE1111 reduces the expressions of TSLP, IL-13, MCP-1, TNF-α, IL-1β and periostin, maintains the expression levels of claudin 1 and involucrin, restores the phagocytic activity of macrophages, and attenuates the activation of STIM1 and phosphorylated AKT. GE1111 exerts anti-inflammatory and anti-allergic effects in multiple animal models. GE1111 is applicable to the research related to rosacea, atopic dermatitis and ulcerative colitis. | ||||||||||||||||||||
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- [1]. Chow BKC, et al. Therapeutic effect of an MRGPRX2/MRGPRB2 antagonist on LL-37-induced rosacea-like inflammation in mice. Inflamm Res. 2025;74(1):174. Published 2025 Nov 26. [Content Brief]
- [2]. Wong TK, et al. MRGPRX2 antagonist GE1111 attenuated DNFB-induced atopic dermatitis in mice by reducing inflammatory cytokines and restoring skin integrity. Front Immunol. 2024;15:1406438. Published 2024 May 16. [Content Brief]
- [3]. Duraisamy K, et al. MRGPRB2/X2 and the analogous effects of its agonist and antagonist in DSS-induced colitis in mice. Biomed Pharmacother. 2024;174:116471. [Content Brief]
Keywords
