3 Results for "

Loncastuximab

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Loncastuximab" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P99711
CAS No.: 1875032-68-0
Synonyms: RB4v1.2

Target:  

CD19 ADC Antibodies

Research Areas:  

Cancer

Loncastuximab (RB4v1.2) is an anti-CD19 monoclonal antibody. Loncastuximab has antitumor activity and can be used in the research of Non-Hodgkin Lymphoma (NHL) and Diffuse Large B-cell Lymphoma (DLBCL). Loncastuximab is capable of synthesizing the ADC molecule Loncastuximab tesirine (HY-P99349) .
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Cat. No.: HY-P99349
CAS No.: 1879918-31-6
Synonyms: Loncastuximab tesirine-lpyl; ADCT-402

Research Areas:  

Cancer

Loncastuximab tesirine is a human cluster of differentiation 19 (CD19)-directed antibody-drug conjugate (ADC). The antibody portion is Loncastuximab (HY-P99711), and the drug-linker conjugate for ADC is Tesirine (HY-128952). Once bound to CD19 on the cell membrane, loncastuximab tesirine is rapidly internalised and triggers cell death. Loncastuximab tesirin induces cell apoptosis, it can be used for the research of diffuse large B-cell lymphoma .
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Cat. No.: HY-175004
CAS No.: 1821339-88-1
Research Areas:  

Cancer

PBD dimer-4 (Compound 7) is a C1-subsitituted PBD dimer. PBD dimer-4 has high DNA-binding affinity, DNA cross-linking ability and potent cytotoxicity against MDA-MB-231 cells (IC50: 236 nM). PBD dimer-4 can be used as a payload of ADC Loncastuximab tesirine (HY-P99349) to treat several different cancer types .
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