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Meliaceae

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Isomer (1) FXR (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

(-)-Umtatin	Drug Isomer	Others
(-)-umtatin is a chiral furochromone. (-)-umtatin can be isolated from Ptaeroxylon obliquum (Meliaceae) .

Voleneol Volenol	Others	Others
Voleneol is a sesquiterpene, that can be isolated from the seeds of Guarea guidonia (MELIACEAE) .

1-O-Deacetylkhayanolide E Deacetylkhayanolide E	Others	Others
1-O-Deacetylkhayanolide E is a khayanolide, which can be isolated from the stem bark of African mahogany Khaya senegalensis .

Ohchinin	Others	Others
Ohchinin is a limonoid, that can be isolated from the fruit of Melia azedarach L. .

Aphagranin A	Others	Others
Aphagranin A (Compound 1) is a protocitric acid compound. Aphagranin A is isolated from the natural Aphanamixis grandifolia .

2-Oxokolavenol	FXR	Others
2-Oxokolavenol is a selective agonist targeting the farnesoid X receptor (FXR), with an EC₅₀ of ~3.7 μM. 2-Oxokolavenol exerts its activity against Acetaminophen (HY-66005)-induced hepatocyte damage in an FXR-dependent manner by binding to the FXR ligand-binding pocket, recruiting co-activators, and inducing FXR transcriptional activity. 2-Oxokolavenol can be naturally extracted from Aglaia spectabilis (a plant of the Aglaia genus in the Meliaceae family) and can be used in research related to liver diseases .

(-)-Umtatin	Structural Classification Natural Products Monophenols Flavonoids Flavones Rutaceae Phenols Plants Source Classification	Drug Isomer
(-)-umtatin is a chiral furochromone. (-)-umtatin can be isolated from Ptaeroxylon obliquum (Meliaceae) .

Voleneol Volenol	Terpenoids Sesquiterpenes Guarea guidonia (L.) Sleumer Plants Meliaceae Source Classification	Others
Voleneol is a sesquiterpene, that can be isolated from the seeds of Guarea guidonia (MELIACEAE) .

1-O-Deacetylkhayanolide E Deacetylkhayanolide E	Natural Products Classification of Application Fields Khaya anthotheca (Welw.) C.DC. Other Diseases Plants Disease Research Fields Meliaceae Source Classification	Others
1-O-Deacetylkhayanolide E is a khayanolide, which can be isolated from the stem bark of African mahogany Khaya senegalensis .

Ohchinin	Triterpenes Melia azedarach Linn. Terpenoids Plants Meliaceae Source Classification	Others
Ohchinin is a limonoid, that can be isolated from the fruit of Melia azedarach L. .

Aphagranin A	Triterpenes Structural Classification Tetracyclic Triterpenoids Terpenoids Plants Meliaceae Aphanamixis polystachya (Wall.) R. N. Parker Source Classification	Others
Aphagranin A (Compound 1) is a protocitric acid compound. Aphagranin A is isolated from the natural Aphanamixis grandifolia .

2-Oxokolavenol	Structural Classification Terpenoids Aglaia lawii (Wight) C. J. Saldanha & Ramamorthy Diterpenoids Plants Meliaceae Source Classification	FXR
2-Oxokolavenol is a selective agonist targeting the farnesoid X receptor (FXR), with an EC₅₀ of ~3.7 μM. 2-Oxokolavenol exerts its activity against Acetaminophen (HY-66005)-induced hepatocyte damage in an FXR-dependent manner by binding to the FXR ligand-binding pocket, recruiting co-activators, and inducing FXR transcriptional activity. 2-Oxokolavenol can be naturally extracted from Aglaia spectabilis (a plant of the Aglaia genus in the Meliaceae family) and can be used in research related to liver diseases .

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