2. Metabolic Enzyme/Protease
  3. FXR
  4. 2-Oxokolavenol

2-Oxokolavenol is a selective agonist targeting the farnesoid X receptor (FXR), with an EC50 of ~3.7 μM. 2-Oxokolavenol exerts its activity against Acetaminophen (HY-66005)-induced hepatocyte damage in an FXR-dependent manner by binding to the FXR ligand-binding pocket, recruiting co-activators, and inducing FXR transcriptional activity. 2-Oxokolavenol can be naturally extracted from Aglaia spectabilis (a plant of the Aglaia genus in the Meliaceae family) and can be used in research related to liver diseases.

For research use only. We do not sell to patients.

2-Oxokolavenol

2-Oxokolavenol Chemical Structure

CAS No. : 130395-82-3

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2-Oxokolavenol Related Antibodies

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Description

2-Oxokolavenol is a selective agonist targeting the farnesoid X receptor (FXR), with an EC50 of ~3.7 μM. 2-Oxokolavenol exerts its activity against Acetaminophen (HY-66005)-induced hepatocyte damage in an FXR-dependent manner by binding to the FXR ligand-binding pocket, recruiting co-activators, and inducing FXR transcriptional activity. 2-Oxokolavenol can be naturally extracted from Aglaia spectabilis (a plant of the Aglaia genus in the Meliaceae family) and can be used in research related to liver diseases[1].

Molecular Weight

304.47

Formula

C20H32O2
CAS No.
SMILES

O=C1C[C@]2([H])[C@@](C)(CC/C(C)=C/CO)[C@H](C)CC[C@@]2(C)C(C)=C1
Structure Classification
Initial Source
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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2-Oxokolavenol Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Oxokolavenol130395-82-3FXRNR1H4Inhibitorinhibitorinhibit

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