1 Result for "

NBI961

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "NBI961" in MCE Product Catalog:

Cat. No.: HY-156437
CAS No.: 2225902-98-5
Purity:  99.73%
Target:  

Apoptosis NEKs Mitosis Akt

Research Areas:  

Cancer

NBI-961 is a NEK2 catalytic inhibitor with human NEK2 IC50 ~12-fold lower than FLT3. NBI-961 induces proteasomal degradation of NEK2. NBI-961 induces G2/mitosis arrest, apoptosis, and compromises viability in DLBCL cells and patient-derived cells. NBI-961 sensitizes DLBCL cells to doxorubicin and vincristine, and suppresses DLBCL tumor growth in mice. NBI-961 can be used for the research of diffuse large b cell lymphoma .
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