2225902-98-5
Chemical Structure
NBI-961
- CAS No.: 2225902-98-5
- Formula:C28H27F3N6O2S
- Molecular Weight:568.61
InChIKey: BQODGOMHYSMCGK-UHFFFAOYSA-N
SMILES: CC(C1=C(C=CC=C1)C(F)(F)F)OC2=C(SC(C3=CN=C4C=C(C=CN34)C5=CN(CCN(C)C)N=C5)=C2)C(N)=O
Biological Activity: NBI-961 is a NEK2 catalytic inhibitor with human NEK2 IC50 ~12-fold lower than FLT3. NBI-961 induces proteasomal degradation of NEK2. NBI-961 induces G2/mitosis arrest, apoptosis, and compromises viability in DLBCL cells and patient-derived cells. NBI-961 sensitizes DLBCL cells to doxorubicin and vincristine, and suppresses DLBCL tumor growth in mice. NBI-961 can be used for the research of diffuse large b cell lymphoma[1].
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NBI-961 | 99.73% | NBI-961 is a NEK2 catalytic inhibitor with human NEK2 IC50 ~12-fold lower than FLT3. NBI-961 induces proteasomal degradation of NEK2. NBI-961 induces G2/mitosis arrest, apoptosis, and compromises viability in DLBCL cells and patient-derived cells. NBI-961 sensitizes DLBCL cells to doxorubicin and vincristine, and suppresses DLBCL tumor growth in mice. NBI-961 can be used for the research of diffuse large b cell lymphoma. | ||||||||||||||||||||
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Keywords
