Nek2-IN-6
Nek2-IN-6 (Compound 28e) is a potent never in mitosis (NIMA) related kinase 2 (Nek2) inhibitor.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2410376-96-2
- 分子式: C33H33F3N6O4S
- 分子量:666.71
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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NEK2 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Bel-7402 | IC50 |
10.44 μM
Compound: 28e
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Antitumor activity against human Bel-7402 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antitumor activity against human Bel-7402 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 32992252] |
| HCT-116 | IC50 |
0.48 μM
Compound: 28e
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Antitumor activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antitumor activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 32992252] |
| Hep 3B2 | IC50 |
1.25 μM
Compound: 28e
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Antitumor activity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antitumor activity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 32992252] |
| MGC-803 | IC50 |
0.038 μM
Compound: 28e
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Antitumor activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antitumor activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 32992252] |
体外実験
Nek2-IN-6 (Compound 28e) (0-30 μM; 72 h) inhibits tumor cells proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MGC-803, Hep-3B, BEL-7402, HCT-116
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Concentration:0-30 μM
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Incubation Time:72 h
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Result:Inhibited cell proliferation with IC50s of 0.038, 1.25, 10.44 and 0.48 μM against MGC-803, Hep-3B, BEL-7402 and HCT-116 cells, respectively.
化学情報
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CAS 番号 2410376-96-2
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分子量 666.71
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分子式 C33H33F3N6O4S
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SMILES
CC(C1=CC=CC=C1C(F)(F)F)OC2=C(SC(C3=CN=C4C=C(C=CN34)C5=CN(N=C5)CC6CN(C6)C(OC(C)(C)C)=O)=C2)C(N)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Nek2-IN-6 関連分類
HY-150046 関連分類
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