Nek2-IN-6
Nek2-IN-6 (Compound 28e) is a potent never in mitosis (NIMA) related kinase 2 (Nek2) inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 2410376-96-2
- Formula: C33H33F3N6O4S
- Molecular Weight:666.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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NEK2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Bel-7402 | IC50 |
10.44 μM
Compound: 28e
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Antitumor activity against human Bel-7402 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antitumor activity against human Bel-7402 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
|
[PMID: 32992252] |
| HCT-116 | IC50 |
0.48 μM
Compound: 28e
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Antitumor activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antitumor activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 32992252] |
| Hep 3B2 | IC50 |
1.25 μM
Compound: 28e
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Antitumor activity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antitumor activity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 32992252] |
| MGC-803 | IC50 |
0.038 μM
Compound: 28e
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Antitumor activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antitumor activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 32992252] |
Nek2-IN-6 (Compound 28e) (0-30 μM; 72 h) inhibits tumor cells proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MGC-803, Hep-3B, BEL-7402, HCT-116
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Concentration:0-30 μM
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Incubation Time:72 h
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Result:Inhibited cell proliferation with IC50s of 0.038, 1.25, 10.44 and 0.48 μM against MGC-803, Hep-3B, BEL-7402 and HCT-116 cells, respectively.
Chemical Information
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CAS No. 2410376-96-2
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Molecular Weight 666.71
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Formula C33H33F3N6O4S
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SMILES
CC(C1=CC=CC=C1C(F)(F)F)OC2=C(SC(C3=CN=C4C=C(C=CN34)C5=CN(N=C5)CC6CN(C6)C(OC(C)(C)C)=O)=C2)C(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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