LY2457546
LY2457546 is a potent and orally active multi-targeted anti-angiogenic tyrosine kinases inhibitor. LY2457546 demonstrates potent activity against targets that include VEGFR2, PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. LY2457546 can be used for the research of cancer, such as leukemia.
For research use only. We do not sell to patients.
- CAS No.: 908265-94-1
- Formula: C28H20F4N4O
- Molecular Weight:504.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All VEGFR Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
VEGFR2 |
PDGFRβ |
Tie2 |
Chemical Information
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CAS No. 908265-94-1
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Molecular Weight 504.48
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Formula C28H20F4N4O
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SMILES
O=C(CC1=CC=C(C2=CN=C3C=C(C4=CC(C)=NC=C4)C=CN32)C=C1F)NC5=CC=CC(C(F)(F)F)=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Burkholder TP, et al. Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model. Invest New Drugs. 2012 Jun;30(3):936-49. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- LY2457546
- 908265-94-1
- LY 2457546
- LY-2457546
- Tyrosinase
- Ephrin Receptor
- VEGFR
- PDGFR
- FLT3
- Tie
- Vascular endothelial growth factor receptor
- Platelet-derived growth factor receptor
- Cluster of differentiation antigen 135
- CD135
- Fms like tyrosine kinase 3
- Angiopoietin receptor
- anti-angiogenic
- VEGFR2
- PDGFRβ
- FLT-3
- Tie-2
- Eph
- leukemia
- cancer
- Inhibitor
- inhibitor
- inhibit