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Nek2-IN-4 is a potent NEK2 inhibitor with an IC50 value of 15 nM. Nek2-IN-4 inhibits cell proliferation. Nek2-IN-4 has the potential for the research of pancreatic cancer.

For research use only. We do not sell to patients.

Nek2-IN-4 Chemical Structure

Nek2-IN-4 Chemical Structure

CAS No. : 2225902-88-3

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Nek2-IN-4 Related Antibodies

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Description

Nek2-IN-4 is a potent NEK2 inhibitor with an IC50 value of 15 nM. Nek2-IN-4 inhibits cell proliferation. Nek2-IN-4 has the potential for the research of pancreatic cancer[1].

IC50 & Target

IC50: 15 nM (NEK2)[1]
In Vitro

Nek2-IN-4 (72 h) inhibits cell growth with IC50s of 0.064, 0.031, 0.161 µM for AsPC-1, PL45, MIA PaCa-2 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nek2-IN-4 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: AsPC-1, PL45, MIA PaCa-2 cells
Concentration:
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50s of 0.064, 0.031, 0.161 µM for AsPC-1, PL45, MIA PaCa-2 cells, respectively.
Molecular Weight

568.61

Formula

C28H27F3N6O2S
CAS No.
SMILES

O=C(C1=C(O[C@H](C2=CC=CC=C2C(F)(F)F)C)C=C(C3=CN=C4C=C(C5=CN(CCN(C)C)N=C5)C=CN43)S1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nek2-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nek2-IN-42225902-88-3OthersAsPC-1PL45MIA PaCa-2antiproliferativepancreatic cancerInhibitorinhibitorinhibit

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