2 Results for "

NCI-H322

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "NCI-H322" in MCE Product Catalog:

Cat. No.: HY-P99719
CAS No.: 1640972-00-4
Synonyms: BAY 1129980; Anti-C4.4a antibody-drug conjugates
Research Areas:  

Cancer

Lupartumab Amadotin (BAY 1129980) is an antibody–drug conjugate (ADC) consisting of a fully human C4.4A (LYPD3)-targeting mAb (BAY 1135626) (HY-147281) conjugated to a novel, highly potent derivative of the microtubule-disrupting cytotoxic drug auristatin via a noncleavable alkyl hydrazide linker. Lupartumab Amadotin can be used for the research of non-small cell lung cancer .
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Cat. No.: HY-P992347

Target:  

CD276/B7-H3

Research Areas:  

Cancer

DS-5573a is a human monoclonal antibody targeting B7-H3, with a Kd of 1.8 nM for the 4Ig isoform and 11 nM for the 2Ig isoform. DS-5573a induces antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis against B7-H3-expressing cancer cells. DS-5573a exerts dose-dependent anti-tumor activity via effector cells. DS-5573a can be used in the research of cancers including breast adenocarcinoma, non-small cell lung cancer, renal cell adenocarcinoma, gastric cancer and prostate cancer .
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