1 Result for "

NIR-BG2

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "NIR-BG2" in MCE Product Catalog:

NIR-BG2
NIR-BG2
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Cat. No.: HY-165424
CAS No.: 3036456-18-2
Category:  

Alkaloids Other Alkaloids Cananga odorata Plants Annonaceae Indole Alkaloids

Target:  

Fluorescent Dye Glycosidase

NIR-BG2 is a fluorescent indicator targeting senescence-associated β-galactosidase (SA-β-Gal). NIR-BG2 contains a hemicyanine fluorophore caged by SA-β-Gal; cleavage of its β-galactosyl group by SA-β-Gal generates an electrophilic quinone methide, which can form covalent bonds with adjacent proteins to achieve long-term signal retention. NIR-BG2 activates a near-infrared fluorescent signal upon recognition of SA-β-Gal. NIR-BG2 can be used for non-invasive in vivo imaging of cellular senescence in mouse xenograft models. The excitation/emission wavelengths are 675/708 nm [2] .
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