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NSP3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (2) SARS-CoV (6) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (2) Infection (6) Neurological Disease (1)
Click Chemistry:	Azide (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162288

FAZ-3532 4 Publications Verification	DNA/RNA Synthesis	Cancer
FAZ-3532 is a *G3BP* inhibitor (K_d = 0.54 μM) which binds to the NTF2L nsP3 binding pocket in G3BP1. FAZ-3532 disrupts the co-condensation of RNA, G3BP1, and caprin 1. FAZ-3532 inhibits G3BP-driven stress granule formation. FAZ-3532 can be studied as a powerful tool to probe the biology of stress granules and a promising interventions designed to modulate stress granule formation .

HY-162289

FAZ-3780 2 Publications Verification	DNA/RNA Synthesis	Neurological Disease Cancer
FAZ-3780 is an inhibitor that binds to the NTF2L domain of *G3BP1/2. FAZ-3780 binds to the NTF2L nsP3* of G3BP1 with high affinity, with a K_d of 0.15 μM and a Pep-FRET IC₅₀ of 0.7 μM. FAZ-3780 targets the protein-protein interaction domain of G3BP1/2, and specifically inhibits the co-condensation of G3BP1, caprin 1 and RNA in vitro. FAZ-3780 inhibits stress granule formation and disassembles pre-formed stress granules. FAZ-3780 can be used in studies related to cancer and neurodegenerative diseases .

HY-150062

*SARS-CoV-2 nsp3-IN-1*	SARS-CoV	Infection
SARS-CoV-2 nsp3-IN-1 (Compound 15c) is a Mac1 (*SARS-CoV-2 nsp3* macrodomain) inhibitor with the IC₅₀** value of 6.1 μM. SARS-CoV-2 nsp3-IN-1 can inhibit Mac1 ADP-ribosylhydrolase activity. SARS-CoV-2 nsp3-IN-1 demonstrates notable selectivity for coronavirus macrodomains, especially towards SARS-CoV-2 Mac1 .

HY-150064

*SARS-CoV-2 nsp3-IN-2*	SARS-CoV	Infection
SARS-CoV-2 nsp3-IN-2 is a macrodomain (Mac1) inhibitor with IC₅₀ value of 180 μM. SARS-CoV-2 nsp3-IN-2 is a small molecule chemical probe and can be used for the research of viral .

HY-174224

Amb929 ZINC000002782982	SARS-CoV	Infection
Amb929 (ZINC000002782982), a *nsp3* ligand, is an anti-SARS-CoV-2 agent. Amb929 inhibits SARS-CoV2-mNG replication in VeroE6 cells with an EC₅₀ of 34.7 µM. Amb929 has limited and moderate cytotoxicity for VeroE6 cells (CC₅₀: 281 µM). Amb929 also inhibits SARS-CoV-2-mNG replication in Human Airway Epithelium (HAE) .

HY-157439

SARS-CoV-2-IN-72	SARS-CoV	Infection
SARS-CoV-2-IN-72 (compound 12) is a potent allosteric inhibitor of the SARS-COV-2 papain-like protease domain that can trigger the degradation of NSP3 .

HY-163785

1"-α-Azido-RDPr	SARS-CoV	Infection
1"-α-Azido-RDPr (Compound 11) is an analog of adenosine diphosphate ribose, and exhibits inhibitory efficacy against the SARS-CoV-2 nonstructural protein macodomain *SARS-CoV-2 NSP3* Mac1 with an IC₅₀** of 30 nM .

HY-178318

LRH-0003	SARS-CoV	Infection
LRH-0003 is an inhibitor of the Macrodomain 1 (Mac1) of nonstructural protein 3 (NSP3) from SARS-CoV-2, with an IC₅₀ value of 1.7 μM. LRH-0003 can be used for the research antiviral infection targeting SARS-CoV-2 .

HY-RS12824

SH2D3C Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SH2D3C Human Pre-designed siRNA Set A contains three designed siRNAs for SH2D3C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SH2D3C Human Pre-designed siRNA Set A SH2D3C Human Pre-designed siRNA Set A

Species:	Virus (6)
Tag:	His (2) Tag Free (4)
Source:	Sf9 insect cells (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74580

	*SARS-CoV-2 NSP3* Protein (sf9, His)** SARS-CoV-2 (2019-nCoV) NSP3 Protein	Virus	Sf9 insect cells
	SARS-CoV-2 NSP3 (NSP3) is one of non-structure protein that binds to viral RNA, nucleocapsid protein, as well as other viral proteins, and contributes in polyprotein processing. NSP3 has also an important role in innate immune response antagonism and is responsible for release of NSP1, NSP2, and NSP3 from the N-terminal region of pp1a and pp1ab. SARS-CoV-2 NSP3 Protein (sf9, His) is the recombinant Virus-derived SARS-CoV-2 NSP3 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P703536

	*SARS-CoV-2 NSP3* Protein (His)** Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; Nuclease; Protease; RNA-binding; Thiol protease; Transferase	Virus	E. coli
	The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. NSP3 Protein, SARS-CoV-2 (His) is the recombinant virus-derived NSP3, expressed by E. coli, with N-His labeled tag.

HY-P703534

	*SARS-CoV-2 NSP3* Protein (372a.a)** Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; Nuclease; Protease; RNA-binding; Thiol protease; Transferase	Virus	E. coli
	The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. NSP3 Protein, SARS-CoV-2 (A1-F372) is the recombinant virus-derived NSP3, expressed by E. coli, with tag-free.

HY-P703535

	*SARS-CoV-2 NSP3* Protein (183a.a)** Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; Nuclease; Protease; RNA-binding; Thiol protease; Transferase	Virus	E. coli
	The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. NSP3 Protein, SARS-CoV-2 (A1-T183) is the recombinant virus-derived NSP3, expressed by E. coli, with tag-free.

HY-P703537

	*SARS-CoV-2 NSP3* Protein (357a.a)** Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; Nuclease; Protease; RNA-binding; Thiol protease; Transferase	Virus	E. coli
	The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. NSP3 Protein, SARS-CoV-2 (I388-R745) is the recombinant virus-derived NSP3, expressed by E. coli, with tag-free.

HY-P703538

	*SARS-CoV-2 NSP3* Protein (338a.a)** Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; Nuclease; Protease; RNA-binding; Thiol protease; Transferase	Virus	E. coli
	The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. NSP3 Protein, SARS-CoV-2 (E746-K1083) is the recombinant virus-derived NSP3, expressed by E. coli, with tag-free.

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HY-P89610

	NSP3 Antibody (YA8954)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human, mouse, rat
	NSP3 Antibody (YA8954) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NSP3.

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Cat. No.	Product Name		Classification

HY-163785

1"-α-Azido-RDPr		Azide
1"-α-Azido-RDPr (Compound 11) is an analog of adenosine diphosphate ribose, and exhibits inhibitory efficacy against the SARS-CoV-2 nonstructural protein macodomain *SARS-CoV-2 NSP3* Mac1 with an IC₅₀** of 30 nM .

Cat. No.	Product Name		Classification

HY-RS12824

SH2D3C Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SH2D3C Human Pre-designed siRNA Set A contains three designed siRNAs for SH2D3C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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